Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts

Cyclin D1 is a key regulator of the G1 phase of the cell cycle. Inhibition of cyclin D1 function results in cell cycle arrest, whereas unregulated expression of the protein accelerates G1. Cyclin D1 is localized to the nucleus during G1. We found that during repair DNA synthesis, subsequent to UV-in...

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Veröffentlicht in:	Genes & development 1994-07, Vol.8 (14), p.1627-1639
Hauptverfasser:	Pagano, M, Theodoras, A M, Tam, S W, Draetta, G F
Format:	Artikel
Sprache:	eng
Schlagworte:	CDC2-CDC28 Kinases Cell Cycle Cell Line Cell Line, Transformed Cyclin D1 Cyclin-Dependent Kinase 2 Cyclin-Dependent Kinase 4 Cyclin-Dependent Kinases - biosynthesis Cyclins - analysis Cyclins - biosynthesis Cyclins - metabolism DNA - biosynthesis DNA - radiation effects DNA Damage DNA Repair DNA Replication fibroblasts Fibroblasts - cytology Fibroblasts - metabolism Gene Expression Humans inhibition Lung man Oncogene Proteins - analysis Oncogene Proteins - biosynthesis Oncogene Proteins - metabolism Plasmids Proliferating Cell Nuclear Antigen - analysis Proliferating Cell Nuclear Antigen - biosynthesis Protein-Serine-Threonine Kinases - biosynthesis Proto-Oncogene Proteins Transfection Ultraviolet Rays
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