Mapping of the Human NMDAR2B Receptor Subunit Gene (GRIN2B) to Chromosome 12p12
The N-methyl-d-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA clon...
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| Veröffentlicht in: | Genomics (San Diego, Calif.) Calif.), 1994-07, Vol.22 (1), p.216-218 |
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| container_title | Genomics (San Diego, Calif.) |
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| creator | Mandich, Paola Schito, Anna M. Bellone, Emily Antonacci, Rachele Finelli, Palma Rocchi, Mariano Ajmar, Franco |
| description | The N-methyl-d-aspartate (NMDA) receptor channel is essential for synaptic transmission and synaptic plasticity underlying memory, learning, and development. Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N -methyl-d-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids. |
| doi_str_mv | 10.1006/geno.1994.1366 |
| format | Article |
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Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. 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Three subunits of the NMDA receptor channel, NMDAR2A, NMDAR2B, and NMDAR2C (NR2A, NR2B, and NR2C), previously identified in mouse by cDNA cloning and expression, share a high level of homology, although their patterns of expression within the brain may differ. In the present work we report the localization of the gene encoding the human NMDAR2B receptor subunit (called GRIN2B for glutamate receptor, ionotropic, N -methyl-d-aspartate 2B) to chromosome 12p12 by in situ hybridization and somatic cell hybrids.</description><subject>Animals</subject><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>Brain - metabolism</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 12</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Primers - genetics</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>Humans</subject><subject>Hybrid Cells</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Mice</subject><subject>Molecular Sequence Data</subject><subject>Protein Conformation</subject><subject>Receptors, N-Methyl-D-Aspartate - chemistry</subject><subject>Receptors, N-Methyl-D-Aspartate - genetics</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1v2zAQhomiQep8rN0KcCiKdJDDo0iKHBO3cQLkA3DSmaCpU8LCEhVSCtB_Xxk2shWdbnife3H3EPIZ2BwYU-fP2MU5GCPmUCr1gcyAaVNoJdRHMmNa66KSovxEjnL-zRgzpeaH5LAy0lRVOSMPd67vQ_dMY0OHF6TXY-s6en_342LFL-kKPfZDTPRxXI9dGOgSO6Rny9XNPb_8TodIFy8ptjHHFinwHvgJOWjcJuPpfh6TX1c_nxbXxe3D8mZxcVv40pihcN5wXWsUjtWsAieFMMKvG9cIoZTW6HgjGaiyXjuYbhZaVJpphUZykFiVx-TbrrdP8XXEPNg2ZI-bjeswjtlWSkMJwP8LglScSSkncL4DfYo5J2xsn0Lr0h8LzG5V261qu1Vtt6qnhS_75nHdYv2O791O-dd97rJ3mya5zof8jgnQMD0zYXqH4aTrLWCy2QfsPNYhoR9sHcO_LvgLyGeVsg</recordid><startdate>19940701</startdate><enddate>19940701</enddate><creator>Mandich, Paola</creator><creator>Schito, Anna M.</creator><creator>Bellone, Emily</creator><creator>Antonacci, Rachele</creator><creator>Finelli, Palma</creator><creator>Rocchi, Mariano</creator><creator>Ajmar, Franco</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19940701</creationdate><title>Mapping of the Human NMDAR2B Receptor Subunit Gene (GRIN2B) to Chromosome 12p12</title><author>Mandich, Paola ; Schito, Anna M. ; Bellone, Emily ; Antonacci, Rachele ; Finelli, Palma ; Rocchi, Mariano ; Ajmar, Franco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c399t-ac928d8e4a0d071a54494cbfaf446688ea2f50163dba193848478086e95215e73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>Brain - metabolism</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 12</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA Primers - genetics</topic><topic>Fundamental and applied biological sciences. 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| ispartof | Genomics (San Diego, Calif.), 1994-07, Vol.22 (1), p.216-218 |
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| subjects | Animals Base Sequence Biological and medical sciences Brain - metabolism Chromosome Mapping Chromosomes, Human, Pair 12 Classical genetics, quantitative genetics, hybrids DNA Primers - genetics Fundamental and applied biological sciences. Psychology Genetics of eukaryotes. Biological and molecular evolution Human Humans Hybrid Cells In Situ Hybridization, Fluorescence Mice Molecular Sequence Data Protein Conformation Receptors, N-Methyl-D-Aspartate - chemistry Receptors, N-Methyl-D-Aspartate - genetics |
| title | Mapping of the Human NMDAR2B Receptor Subunit Gene (GRIN2B) to Chromosome 12p12 |
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