U4/U5/U6 snRNP recognizes the 5' splice site in the absence of U2 snRNP

Using an in vitro system in which a 5' splice site (5'SS) RNA oligo (AAG decreases GUAAGUAdT) is capable of inducing formation of U2/U4/U5/U6 snRNP complex we show that this oligo specifically binds to U4/U5/U6 snRNP and cross-links to U6 snRNA in the absence of U2 snRNP. Moreover, 5'...

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Veröffentlicht in:	Genes & development 1994-08, Vol.8 (16), p.1962-1973
Hauptverfasser:	Konforti, B B, Konarska, M M
Format:	Artikel
Sprache:	eng
Schlagworte:	Base Sequence Binding Sites - genetics Consensus Sequence Cross-Linking Reagents DNA - genetics HeLa Cells Humans Molecular Sequence Data Point Mutation Ribonucleoprotein, U1 Small Nuclear - genetics Ribonucleoprotein, U1 Small Nuclear - metabolism Ribonucleoprotein, U2 Small Nuclear - genetics Ribonucleoprotein, U2 Small Nuclear - metabolism Ribonucleoprotein, U4-U6 Small Nuclear - genetics Ribonucleoprotein, U4-U6 Small Nuclear - metabolism RNA Splicing - genetics Spliceosomes - metabolism
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