Do indomethacin and cimetidine or Cu(cimetadine) 2 affect the nature of superoxide dismutase activity in the liver of copper-deficient rats?
1. Control and copper-deficient rats were treated with: (i) indomethacin; (ii) indomethacin in the presence of cimetidine; and (iii) indomethacin in the presence of Cu(cimetidine) 2. The levels of copper, zinc and manganese as well as the nature of superoxide dismutase activity in the liver were stu...
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| Veröffentlicht in: | General pharmacology 1994-07, Vol.25 (4), p.645-650 |
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| creator | Konstantinova, Sofia G. Radeva-Domuschieva, Diana R. Russanov, Elevter M. |
| description | 1. Control and copper-deficient rats were treated with: (i) indomethacin; (ii) indomethacin in the presence of cimetidine; and (iii) indomethacin in the presence of Cu(cimetidine)
2. The levels of copper, zinc and manganese as well as the nature of superoxide dismutase activity in the liver were studied.
2. Copper deficiency caused a decrease of enzyme SOD activity, EDTA-insensitive (by 84%) and the appearance of nonenzyme SOD-like activity, EDTA-sensitive. The levels of copper and zinc decreased by 67% and 40% and the manganese level increased by 53%.
3. The above-mentioned treatments (i, ii, iii) of copper-deficient rats induced a progressive increase of enzyme SOD activity (by 19, 90 and 176%, respectively) without, however, changing nonenzyme SOD-like activity. It was only indomethacin treatment in the presence of Cu(cimetidine)
2 that increased the copper level in control (by 82%) and copper-deficient (by 182%) rats.
4. The liver contained 4 CuZnSOD- and 1 MnSOD-isoenzymes, whose number and position on the gel were affected neither by copper deficiency nor by indomethacin treatment in the presence of Cu(cimetidine)
2. Copper deficiency significantly increased the MnSOD-band and reduced the CuZnSOD-bands, particularly that with pI ∼ 5.7. Indomethacin in the presence of Cu(cimetidine)
2 changed neither the MnSOD-band nor the reduced CuZnSOD-band with pI ∼ 5.7, but restored to normal all the other CuZnSOD-bands. |
| doi_str_mv | 10.1016/0306-3623(94)90241-0 |
| format | Article |
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2. The levels of copper, zinc and manganese as well as the nature of superoxide dismutase activity in the liver were studied.
2. Copper deficiency caused a decrease of enzyme SOD activity, EDTA-insensitive (by 84%) and the appearance of nonenzyme SOD-like activity, EDTA-sensitive. The levels of copper and zinc decreased by 67% and 40% and the manganese level increased by 53%.
3. The above-mentioned treatments (i, ii, iii) of copper-deficient rats induced a progressive increase of enzyme SOD activity (by 19, 90 and 176%, respectively) without, however, changing nonenzyme SOD-like activity. It was only indomethacin treatment in the presence of Cu(cimetidine)
2 that increased the copper level in control (by 82%) and copper-deficient (by 182%) rats.
4. The liver contained 4 CuZnSOD- and 1 MnSOD-isoenzymes, whose number and position on the gel were affected neither by copper deficiency nor by indomethacin treatment in the presence of Cu(cimetidine)
2. Copper deficiency significantly increased the MnSOD-band and reduced the CuZnSOD-bands, particularly that with pI ∼ 5.7. Indomethacin in the presence of Cu(cimetidine)
2 changed neither the MnSOD-band nor the reduced CuZnSOD-band with pI ∼ 5.7, but restored to normal all the other CuZnSOD-bands.</description><identifier>ISSN: 0306-3623</identifier><identifier>EISSN: 1879-0011</identifier><identifier>DOI: 10.1016/0306-3623(94)90241-0</identifier><identifier>PMID: 7958724</identifier><identifier>CODEN: GEPHDP</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; cimetidine ; Cimetidine - pharmacology ; Copper - analysis ; Copper - deficiency ; Digestive system ; Indomethacin ; Indomethacin - pharmacology ; Isoenzymes - metabolism ; Liver - enzymology ; Male ; Manganese - analysis ; Medical sciences ; Pharmacology. Drug treatments ; rat liver ; Rats ; Rats, Wistar ; superoxide dismutase ; Superoxide Dismutase - metabolism ; Zinc - analysis</subject><ispartof>General pharmacology, 1994-07, Vol.25 (4), p.645-650</ispartof><rights>1994</rights><rights>1994 INIST-CNRS</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c250t-9f479a76836110a6745dc607cbc39f2159c574a084064cc7ac135c10e8d5cee63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4155600$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7958724$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Konstantinova, Sofia G.</creatorcontrib><creatorcontrib>Radeva-Domuschieva, Diana R.</creatorcontrib><creatorcontrib>Russanov, Elevter M.</creatorcontrib><title>Do indomethacin and cimetidine or Cu(cimetadine) 2 affect the nature of superoxide dismutase activity in the liver of copper-deficient rats?</title><title>General pharmacology</title><addtitle>Gen Pharmacol</addtitle><description>1. Control and copper-deficient rats were treated with: (i) indomethacin; (ii) indomethacin in the presence of cimetidine; and (iii) indomethacin in the presence of Cu(cimetidine)
2. The levels of copper, zinc and manganese as well as the nature of superoxide dismutase activity in the liver were studied.
2. Copper deficiency caused a decrease of enzyme SOD activity, EDTA-insensitive (by 84%) and the appearance of nonenzyme SOD-like activity, EDTA-sensitive. The levels of copper and zinc decreased by 67% and 40% and the manganese level increased by 53%.
3. The above-mentioned treatments (i, ii, iii) of copper-deficient rats induced a progressive increase of enzyme SOD activity (by 19, 90 and 176%, respectively) without, however, changing nonenzyme SOD-like activity. It was only indomethacin treatment in the presence of Cu(cimetidine)
2 that increased the copper level in control (by 82%) and copper-deficient (by 182%) rats.
4. The liver contained 4 CuZnSOD- and 1 MnSOD-isoenzymes, whose number and position on the gel were affected neither by copper deficiency nor by indomethacin treatment in the presence of Cu(cimetidine)
2. Copper deficiency significantly increased the MnSOD-band and reduced the CuZnSOD-bands, particularly that with pI ∼ 5.7. Indomethacin in the presence of Cu(cimetidine)
2 changed neither the MnSOD-band nor the reduced CuZnSOD-band with pI ∼ 5.7, but restored to normal all the other CuZnSOD-bands.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>cimetidine</subject><subject>Cimetidine - pharmacology</subject><subject>Copper - analysis</subject><subject>Copper - deficiency</subject><subject>Digestive system</subject><subject>Indomethacin</subject><subject>Indomethacin - pharmacology</subject><subject>Isoenzymes - metabolism</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Manganese - analysis</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>rat liver</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Zinc - analysis</subject><issn>0306-3623</issn><issn>1879-0011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1DAUhS0EKtOBNwDJC4TaReDasZ1kU4Sm_EmV2MDacq9vVKNMMtjOiL4DD40zM5olK8vnfj7XOoexVwLeCRDmPdRgqtrI-qpT1x1IJSp4wlaibboKQIinbHVGnrPLlH4BgNRSXrCLptNtI9WK_b2deBj9tKX84DCM3I2eYyjX4MNIfIp8M18dBLcI11xy1_eEmecH4qPLcyxUz9O8ozj9CZ64D2k7Z5eIO8xhH_JjWXHAh7CnuNA47QpeeeoDBhozjy6nDy_Ys94NiV6ezjX7-fnTj83X6u77l2-bj3cVSg256nrVdK4xbW2EAGcapT0aaPAe666XQneoG-WgVWAUYuNQ1BoFUOs1Epl6zd4efXdx-j1TynYbEtIwuJGmOdliLaQ2dQHVEcQ4pRSpt7sYti4-WgF2KcEuCdslYdspeyihSGv2-uQ_32_Jnx-dUi_zN6e5S-iGProRQzpjSmhtYLG5OWJUstgHijYtYSH5EEsB1k_h___4B4Cmo5o</recordid><startdate>199407</startdate><enddate>199407</enddate><creator>Konstantinova, Sofia G.</creator><creator>Radeva-Domuschieva, Diana R.</creator><creator>Russanov, Elevter M.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199407</creationdate><title>Do indomethacin and cimetidine or Cu(cimetadine) 2 affect the nature of superoxide dismutase activity in the liver of copper-deficient rats?</title><author>Konstantinova, Sofia G. ; Radeva-Domuschieva, Diana R. ; Russanov, Elevter M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-9f479a76836110a6745dc607cbc39f2159c574a084064cc7ac135c10e8d5cee63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>cimetidine</topic><topic>Cimetidine - pharmacology</topic><topic>Copper - analysis</topic><topic>Copper - deficiency</topic><topic>Digestive system</topic><topic>Indomethacin</topic><topic>Indomethacin - pharmacology</topic><topic>Isoenzymes - metabolism</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Manganese - analysis</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>rat liver</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Zinc - analysis</topic><toplevel>online_resources</toplevel><creatorcontrib>Konstantinova, Sofia G.</creatorcontrib><creatorcontrib>Radeva-Domuschieva, Diana R.</creatorcontrib><creatorcontrib>Russanov, Elevter M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>General pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Konstantinova, Sofia G.</au><au>Radeva-Domuschieva, Diana R.</au><au>Russanov, Elevter M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do indomethacin and cimetidine or Cu(cimetadine) 2 affect the nature of superoxide dismutase activity in the liver of copper-deficient rats?</atitle><jtitle>General pharmacology</jtitle><addtitle>Gen Pharmacol</addtitle><date>1994-07</date><risdate>1994</risdate><volume>25</volume><issue>4</issue><spage>645</spage><epage>650</epage><pages>645-650</pages><issn>0306-3623</issn><eissn>1879-0011</eissn><coden>GEPHDP</coden><abstract>1. Control and copper-deficient rats were treated with: (i) indomethacin; (ii) indomethacin in the presence of cimetidine; and (iii) indomethacin in the presence of Cu(cimetidine)
2. The levels of copper, zinc and manganese as well as the nature of superoxide dismutase activity in the liver were studied.
2. Copper deficiency caused a decrease of enzyme SOD activity, EDTA-insensitive (by 84%) and the appearance of nonenzyme SOD-like activity, EDTA-sensitive. The levels of copper and zinc decreased by 67% and 40% and the manganese level increased by 53%.
3. The above-mentioned treatments (i, ii, iii) of copper-deficient rats induced a progressive increase of enzyme SOD activity (by 19, 90 and 176%, respectively) without, however, changing nonenzyme SOD-like activity. It was only indomethacin treatment in the presence of Cu(cimetidine)
2 that increased the copper level in control (by 82%) and copper-deficient (by 182%) rats.
4. The liver contained 4 CuZnSOD- and 1 MnSOD-isoenzymes, whose number and position on the gel were affected neither by copper deficiency nor by indomethacin treatment in the presence of Cu(cimetidine)
2. Copper deficiency significantly increased the MnSOD-band and reduced the CuZnSOD-bands, particularly that with pI ∼ 5.7. Indomethacin in the presence of Cu(cimetidine)
2 changed neither the MnSOD-band nor the reduced CuZnSOD-band with pI ∼ 5.7, but restored to normal all the other CuZnSOD-bands.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>7958724</pmid><doi>10.1016/0306-3623(94)90241-0</doi><tpages>6</tpages></addata></record> |
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| ispartof | General pharmacology, 1994-07, Vol.25 (4), p.645-650 |
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| subjects | Animals Biological and medical sciences cimetidine Cimetidine - pharmacology Copper - analysis Copper - deficiency Digestive system Indomethacin Indomethacin - pharmacology Isoenzymes - metabolism Liver - enzymology Male Manganese - analysis Medical sciences Pharmacology. Drug treatments rat liver Rats Rats, Wistar superoxide dismutase Superoxide Dismutase - metabolism Zinc - analysis |
| title | Do indomethacin and cimetidine or Cu(cimetadine) 2 affect the nature of superoxide dismutase activity in the liver of copper-deficient rats? |
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