Pharmacokinetics of Pentaerythritol Tetranitrate following Intra-Arterial and Oral Dosing in the Rat

The pharmacokinetics of pentaerythritol tetranitrate (2,2-bis(hydroxymethyl)-1, 3-propanediol tetranitrate, 1) were studied in rats following a single intra-arterial or oral dose (2mg/kg) of the 14C-labeled drug. Blood levels of the tetranitrate and its metabolites were determined using a thin-layer...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1986-03, Vol.75 (3), p.247-250
Hauptverfasser:	King, Shang-Ying P., Fung, Ho-Leung
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Animals Biological and medical sciences Cardiovascular system Chromatography, Thin Layer Feces - analysis Injections, Intra-Arterial Kinetics Male Medical sciences Pentaerythritol Tetranitrate - administration & dosage Pentaerythritol Tetranitrate - metabolism Pentaerythritol Tetranitrate - urine Pharmacology. Drug treatments Rats Rats, Inbred Strains Vasodilator agents. Cerebral vasodilators
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