Selective inactivity of TGF-β/decorin complexes

Previous studies had shown that binding of TGF-β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF-β1-mediated up-regulation of biglycan synthesis. However, the down-regulation of proteoglycan-100 remained unaltered...

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Veröffentlicht in:	FEBS letters 1994-10, Vol.353 (3), p.243-245
Hauptverfasser:	Hausser, Heinz, Gröning, Arndt, Hasilik, Andrej, Schönherr, Elke, Kresse, Hans
Format:	Artikel
Sprache:	eng
Schlagworte:	Biglycan Cell Division - drug effects Collagen Collagen-gel retraction Decorin Down-Regulation - drug effects Down-Regulation - physiology Extracellular Matrix Proteins Humans Monocytes - cytology Monocytes - metabolism Osteosarcoma - metabolism Proteoglycan-100 Proteoglycans - biosynthesis Proteoglycans - metabolism Proteoglycans - pharmacology TGF-β Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Tumor Cells, Cultured
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