Selective inactivity of TGF-β/decorin complexes
Previous studies had shown that binding of TGF-β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF-β1-mediated up-regulation of biglycan synthesis. However, the down-regulation of proteoglycan-100 remained unaltered...
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| Veröffentlicht in: | FEBS letters 1994-10, Vol.353 (3), p.243-245 |
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| container_title | FEBS letters |
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| creator | Hausser, Heinz Gröning, Arndt Hasilik, Andrej Schönherr, Elke Kresse, Hans |
| description | Previous studies had shown that binding of TGF-β to the small proteoglycan decorin results in its inactivation. Indeed, in osteosarcoma cells the addition of decorin prevented the TGF-β1-mediated up-regulation of biglycan synthesis. However, the down-regulation of proteoglycan-100 remained unaltered. Even in the presence of a 100,000-fold molar excess of decorin, TGF-β1 was fully active in U937 monocytes with respect to the inhibition of cell proliferation. There was no inhibition of the TGF-β-mediated stimulation of the retraction of fibroblast-populated collagen lattices. Thus, the formation of TGF-β/decorin complexes leads to the neutralization of distinct effects only. |
| doi_str_mv | 10.1016/0014-5793(94)01044-7 |
| format | Article |
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| ispartof | FEBS letters, 1994-10, Vol.353 (3), p.243-245 |
| issn | 0014-5793 1873-3468 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Biglycan Cell Division - drug effects Collagen Collagen-gel retraction Decorin Down-Regulation - drug effects Down-Regulation - physiology Extracellular Matrix Proteins Humans Monocytes - cytology Monocytes - metabolism Osteosarcoma - metabolism Proteoglycan-100 Proteoglycans - biosynthesis Proteoglycans - metabolism Proteoglycans - pharmacology TGF-β Transforming Growth Factor beta - metabolism Transforming Growth Factor beta - pharmacology Tumor Cells, Cultured |
| title | Selective inactivity of TGF-β/decorin complexes |
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