Polymorphisms and Linkage Analysis for ICAM-1 and the Selectin Gene Cluster
Genetic polymorphisms in leukocyte and endothelial cell adhesion molecules may be important variables with regard to susceptibility to multifactorial disease processes that include an inflammatory component. For this reason, polymorphisms were sought for intercellular adhesion molecule-1 (ICAM-1; ge...
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| Veröffentlicht in: | Genomics 1994-06, Vol.21 (3), p.473-477 |
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| creator | Vora, Devendra K. Rosenbloom, Craig L. Beaudet, Arthur L. Cottingham, Robert W. |
| description | Genetic polymorphisms in leukocyte and endothelial cell adhesion molecules may be important variables with regard to susceptibility to multifactorial disease processes that include an inflammatory component. For this reason, polymorphisms were sought for intercellular adhesion molecule-1 (ICAM-1; gene symbol ICAM1) and for the three genes in the selectin cluster, P-selectin, L-selectin, and E-selectin (gene symbols SELP, SELL, and SELE, respectively). Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469. Dinucleotide repeat polymorphisms were identified in the 3′-untranslated region for ICAM-1 and in intron 9 for P-selectin. Restriction fragment length polymorphisms were found using cDNAs for each of the three selectin genes as probes; E-selectin with BglII, P-selectin with ScaI, and L-selectin with HincII. Linkage analysis was performed for the selectin gene cluster and for ICAM-1 using the CEPH families; ICAM-1 is very tightly linked to the LDL receptor on chromosome 19, and the selectin cluster is linked to markers at chromosome 1q23. |
| doi_str_mv | 10.1006/geno.1994.1303 |
| format | Article |
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For this reason, polymorphisms were sought for intercellular adhesion molecule-1 (ICAM-1; gene symbol ICAM1) and for the three genes in the selectin cluster, P-selectin, L-selectin, and E-selectin (gene symbols SELP, SELL, and SELE, respectively). Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469. Dinucleotide repeat polymorphisms were identified in the 3′-untranslated region for ICAM-1 and in intron 9 for P-selectin. Restriction fragment length polymorphisms were found using cDNAs for each of the three selectin genes as probes; E-selectin with BglII, P-selectin with ScaI, and L-selectin with HincII. Linkage analysis was performed for the selectin gene cluster and for ICAM-1 using the CEPH families; ICAM-1 is very tightly linked to the LDL receptor on chromosome 19, and the selectin cluster is linked to markers at chromosome 1q23.</description><identifier>ISSN: 0888-7543</identifier><identifier>EISSN: 1089-8646</identifier><identifier>DOI: 10.1006/geno.1994.1303</identifier><identifier>PMID: 7525451</identifier><language>eng</language><publisher>San Diego, CA: Elsevier Inc</publisher><subject>Base Sequence ; Biological and medical sciences ; BIOLOGY AND MEDICINE, BASIC STUDIES ; Cell Adhesion Molecules - genetics ; Classical genetics, quantitative genetics, hybrids ; DNA Primers ; E-Selectin ; Fundamental and applied biological sciences. Psychology ; GENE MUTATIONS ; GENES ; Genetic Linkage ; GENETIC MAPPING ; Genetics of eukaryotes. Biological and molecular evolution ; Human ; HUMAN CHROMOSOME 1 ; HUMAN CHROMOSOME 9 ; Humans ; Intercellular Adhesion Molecule-1 - genetics ; L-Selectin ; MEMBRANE PROTEINS ; Molecular Sequence Data ; Multigene Family ; P-Selectin ; Platelet Membrane Glycoproteins - genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Repetitive Sequences, Nucleic Acid ; Restriction Mapping ; RFLPS</subject><ispartof>Genomics, 1994-06, Vol.21 (3), p.473-477</ispartof><rights>1994 Academic Press</rights><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c394t-fcf704ff34da0e09dedb05ae1feeb51ae2eff94381e5cd3a7bee0d32c48e12f83</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/geno.1994.1303$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,885,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4122172$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7525451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://www.osti.gov/biblio/250043$$D View this record in Osti.gov$$Hfree_for_read</backlink></links><search><creatorcontrib>Vora, Devendra K.</creatorcontrib><creatorcontrib>Rosenbloom, Craig L.</creatorcontrib><creatorcontrib>Beaudet, Arthur L.</creatorcontrib><creatorcontrib>Cottingham, Robert W.</creatorcontrib><title>Polymorphisms and Linkage Analysis for ICAM-1 and the Selectin Gene Cluster</title><title>Genomics</title><addtitle>Genomics</addtitle><description>Genetic polymorphisms in leukocyte and endothelial cell adhesion molecules may be important variables with regard to susceptibility to multifactorial disease processes that include an inflammatory component. For this reason, polymorphisms were sought for intercellular adhesion molecule-1 (ICAM-1; gene symbol ICAM1) and for the three genes in the selectin cluster, P-selectin, L-selectin, and E-selectin (gene symbols SELP, SELL, and SELE, respectively). Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469. Dinucleotide repeat polymorphisms were identified in the 3′-untranslated region for ICAM-1 and in intron 9 for P-selectin. Restriction fragment length polymorphisms were found using cDNAs for each of the three selectin genes as probes; E-selectin with BglII, P-selectin with ScaI, and L-selectin with HincII. Linkage analysis was performed for the selectin gene cluster and for ICAM-1 using the CEPH families; ICAM-1 is very tightly linked to the LDL receptor on chromosome 19, and the selectin cluster is linked to markers at chromosome 1q23.</description><subject>Base Sequence</subject><subject>Biological and medical sciences</subject><subject>BIOLOGY AND MEDICINE, BASIC STUDIES</subject><subject>Cell Adhesion Molecules - genetics</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>DNA Primers</subject><subject>E-Selectin</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GENE MUTATIONS</subject><subject>GENES</subject><subject>Genetic Linkage</subject><subject>GENETIC MAPPING</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Human</subject><subject>HUMAN CHROMOSOME 1</subject><subject>HUMAN CHROMOSOME 9</subject><subject>Humans</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>L-Selectin</subject><subject>MEMBRANE PROTEINS</subject><subject>Molecular Sequence Data</subject><subject>Multigene Family</subject><subject>P-Selectin</subject><subject>Platelet Membrane Glycoproteins - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>Repetitive Sequences, Nucleic Acid</subject><subject>Restriction Mapping</subject><subject>RFLPS</subject><issn>0888-7543</issn><issn>1089-8646</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kE1vEzEQhi1UVNLAlRvSVkLcNow_dtd7rKLSVgSBBJwtxx43hl072Buk_Hu8JOqtpzm8zzuaeQh5S2FFAdqPjxjiiva9WFEO_AVZUJB9LVvRXpAFSCnrrhH8FbnK-RcA9FyyS3LZNawRDV2Qz9_icBxj2u98HnOlg602PvzWj1jdBD0cs8-Vi6l6WN98qen_fNph9R0HNJMP1R0GrNbDIU-YXpOXTg8Z35znkvz8dPtjfV9vvt6V_qY2vBdT7YzrQDjHhdWA0Fu0W2g0Uoe4bahGhs71gkuKjbFcd1tEsJwZIZEyJ_mSXJ_2xjx5lY2f0OxMDKGcpFgDIHhhPpyYfYp_DpgnNfpscBh0wHjIqmtlcQFtAVcn0KSYc0Kn9smPOh0VBTUbVrNhNRtWs-FSeHfefNiOaJ_ws9KSvz_nOhs9uKSD8fkJE5Qx2rGCyROGxdRfj2l-BINB69P8h43-uQv-AfAOluE</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Vora, Devendra K.</creator><creator>Rosenbloom, Craig L.</creator><creator>Beaudet, Arthur L.</creator><creator>Cottingham, Robert W.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>OTOTI</scope></search><sort><creationdate>19940601</creationdate><title>Polymorphisms and Linkage Analysis for ICAM-1 and the Selectin Gene Cluster</title><author>Vora, Devendra K. ; Rosenbloom, Craig L. ; Beaudet, Arthur L. ; Cottingham, Robert W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c394t-fcf704ff34da0e09dedb05ae1feeb51ae2eff94381e5cd3a7bee0d32c48e12f83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Base Sequence</topic><topic>Biological and medical sciences</topic><topic>BIOLOGY AND MEDICINE, BASIC STUDIES</topic><topic>Cell Adhesion Molecules - genetics</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>DNA Primers</topic><topic>E-Selectin</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GENE MUTATIONS</topic><topic>GENES</topic><topic>Genetic Linkage</topic><topic>GENETIC MAPPING</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Human</topic><topic>HUMAN CHROMOSOME 1</topic><topic>HUMAN CHROMOSOME 9</topic><topic>Humans</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>L-Selectin</topic><topic>MEMBRANE PROTEINS</topic><topic>Molecular Sequence Data</topic><topic>Multigene Family</topic><topic>P-Selectin</topic><topic>Platelet Membrane Glycoproteins - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>Repetitive Sequences, Nucleic Acid</topic><topic>Restriction Mapping</topic><topic>RFLPS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Vora, Devendra K.</creatorcontrib><creatorcontrib>Rosenbloom, Craig L.</creatorcontrib><creatorcontrib>Beaudet, Arthur L.</creatorcontrib><creatorcontrib>Cottingham, Robert W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>OSTI.GOV</collection><jtitle>Genomics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Vora, Devendra K.</au><au>Rosenbloom, Craig L.</au><au>Beaudet, Arthur L.</au><au>Cottingham, Robert W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polymorphisms and Linkage Analysis for ICAM-1 and the Selectin Gene Cluster</atitle><jtitle>Genomics</jtitle><addtitle>Genomics</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>21</volume><issue>3</issue><spage>473</spage><epage>477</epage><pages>473-477</pages><issn>0888-7543</issn><eissn>1089-8646</eissn><abstract>Genetic polymorphisms in leukocyte and endothelial cell adhesion molecules may be important variables with regard to susceptibility to multifactorial disease processes that include an inflammatory component. For this reason, polymorphisms were sought for intercellular adhesion molecule-1 (ICAM-1; gene symbol ICAM1) and for the three genes in the selectin cluster, P-selectin, L-selectin, and E-selectin (gene symbols SELP, SELL, and SELE, respectively). Two amino acid polymorphisms were identified for ICAM-1; Gly or Arg at codon 241 and Lys or Glu at codon 469. Dinucleotide repeat polymorphisms were identified in the 3′-untranslated region for ICAM-1 and in intron 9 for P-selectin. Restriction fragment length polymorphisms were found using cDNAs for each of the three selectin genes as probes; E-selectin with BglII, P-selectin with ScaI, and L-selectin with HincII. Linkage analysis was performed for the selectin gene cluster and for ICAM-1 using the CEPH families; ICAM-1 is very tightly linked to the LDL receptor on chromosome 19, and the selectin cluster is linked to markers at chromosome 1q23.</abstract><cop>San Diego, CA</cop><pub>Elsevier Inc</pub><pmid>7525451</pmid><doi>10.1006/geno.1994.1303</doi><tpages>5</tpages></addata></record> |
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| subjects | Base Sequence Biological and medical sciences BIOLOGY AND MEDICINE, BASIC STUDIES Cell Adhesion Molecules - genetics Classical genetics, quantitative genetics, hybrids DNA Primers E-Selectin Fundamental and applied biological sciences. Psychology GENE MUTATIONS GENES Genetic Linkage GENETIC MAPPING Genetics of eukaryotes. Biological and molecular evolution Human HUMAN CHROMOSOME 1 HUMAN CHROMOSOME 9 Humans Intercellular Adhesion Molecule-1 - genetics L-Selectin MEMBRANE PROTEINS Molecular Sequence Data Multigene Family P-Selectin Platelet Membrane Glycoproteins - genetics Polymerase Chain Reaction Polymorphism, Genetic Repetitive Sequences, Nucleic Acid Restriction Mapping RFLPS |
| title | Polymorphisms and Linkage Analysis for ICAM-1 and the Selectin Gene Cluster |
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