The inhibitory effects of 5-fluorouracil on the metabolism of preribosomal and ribosomal RNA in L-1210 cells in vitro

Addition of 5FU to the culture medium of mouse L-1210 cells resulted in inhibition of the maturation process of ribosomal RNA precursors in vitro. In the presence of 10(-6) M 5FU for 2 h, the 45S preribosomal RNA was processed to 32S preribosomal RNA, but 28S rRNA was not produced. The processing to...

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Veröffentlicht in:	Cancer chemotherapy and pharmacology 1986-05, Vol.17 (1), p.43-46
Hauptverfasser:	KANAMARU, R, KAKUTA, H, SATO, T, ISHIOKA, C, WAKUI, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Biological and medical sciences Cell Line Centrifugation, Density Gradient Fluorouracil - metabolism Fluorouracil - pharmacology General aspects Leukemia L1210 - metabolism Medical sciences Mice Pharmacology. Drug treatments RNA Processing, Post-Transcriptional - drug effects RNA, Neoplasm - metabolism RNA, Ribosomal - metabolism
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