Ageing-associated tandem duplications in the D-loop of mitochondrial DNA of human muscle

Using PCR techniques, we detected a ∼260 bp (type I) and a ∼200 bp (type II) tandem duplications in the mtDNA of muscle biopsies from aged individuals. Only one 70-year-old subject was found to harbour the type I and 28 out of 58 subjects had type II duplication. About 90% of the subjects harbouring...

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