Effects of 4-(o-Benzylphenoxy)-N-methylbutylamine hydrochloride (MCI-2016, bifemelane hydrochloride) on coagulation, fibrinolysis, hemolysis, hemorheological properties and platelet aggregation

MCI-2016 showed little influence on coagulation (APTT) and fibrinolysis (plasma clot lysis activated by urokinase) at doses (concentrations) as high as 300 mg/kg, p.o. or 8.6×10-4 M. Hemolytic action of MCI-2016 was only observed at the concentrations above 2 mM. The drug also showed no influence on...

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Veröffentlicht in:	Folia Pharmacologica Japonica 1986, Vol.87(2), pp.161-167
Hauptverfasser:	TAMAO, Yoshikuni, HARA, Hiroto, UMEZU, Kohei, ITO, Jindo, DOI, Akiko, SUDO, Atsuko, HIRATA, Tomoko, MINEO, Kyoko, TOBE, Akihiro
Format:	Artikel
Sprache:	jpn
Schlagworte:	Animals Benzhydryl Compounds - pharmacology Blood - drug effects Blood Coagulation - drug effects Blood Glucose - analysis Blood Viscosity - drug effects Erythrocytes - drug effects Fibrinolysis - drug effects Male Platelet Aggregation - drug effects Rabbits Rats Rats, Inbred Strains Rheology
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