Evidence for the appearance of an uncoupled form of the β-adrenergic receptor distinct from the internalized receptor

Agonist treatment of C6‐glioma cells induces two altered states in β‐adrenergic receptors, a low affinity for the hydrophilic antagonist CGP‐12177 and a low affinity for agonists like isoproterenol. We present evidence that, in cells not treated to inhibit receptor internalization, the two propertie...

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Veröffentlicht in:	Journal of cellular biochemistry 1986, Vol.30 (3), p.219-225
Hauptverfasser:	Hertel, C., Portenier, M., Staehelin, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Agonists - pharmacology Adrenergic beta-Antagonists - pharmacology Animals Biological and medical sciences Cell Membrane - drug effects Cell receptors Cell structures and functions Cells, Cultured CGP-12177 Dose-Response Relationship, Drug Fundamental and applied biological sciences. Psychology Glioma - metabolism internalization Isoproterenol - metabolism Molecular and cellular biology Propanolamines - metabolism Receptor Aggregation - drug effects Receptors, Adrenergic, beta - analysis Receptors, Adrenergic, beta - metabolism recycling Time Factors uncoupling β-adrenergic receptors
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