Invasion of Erythrocytes by Plasmodium falciparum Malaria Parasites: Evidence for Receptor Heterogeneity and Two Receptors
Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes...
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| Veröffentlicht in: | Blood 1986-05, Vol.67 (5), p.1519-1521 |
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| container_title | Blood |
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| creator | Mitchell, Graham H. Hadley, Terence J. McGinniss, Mary H. Klotz, Francis W. Miller, Louis H. |
| description | Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuramin-idase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand. |
| doi_str_mv | 10.1182/blood.V67.5.1519.1519 |
| format | Article |
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Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuramin-idase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand.</description><identifier>ISSN: 0006-4971</identifier><identifier>EISSN: 1528-0020</identifier><identifier>DOI: 10.1182/blood.V67.5.1519.1519</identifier><identifier>PMID: 3516259</identifier><language>eng</language><publisher>Washington, DC: Elsevier Inc</publisher><subject>Binding Sites ; Biochemistry. Physiology. Immunology. Molecular biology ; Biological and medical sciences ; Erythrocyte Membrane - physiology ; Erythrocytes - metabolism ; Erythrocytes - parasitology ; Fundamental and applied biological sciences. Psychology ; Human protozoal diseases ; Humans ; Infectious diseases ; Malaria ; Medical sciences ; Neuraminidase - metabolism ; Parasitic diseases ; Plasmodium falciparum - pathogenicity ; Protozoa ; Protozoal diseases ; Sialic Acids - blood ; Tropical medicine ; Trypsin - metabolism</subject><ispartof>Blood, 1986-05, Vol.67 (5), p.1519-1521</ispartof><rights>1986 American Society of Hematology</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3519-c5969b9d83072f6343a9ff05659e6db6d85bdf5aa5f2e129b82dd2aebe70d16c3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7922144$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3516259$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mitchell, Graham H.</creatorcontrib><creatorcontrib>Hadley, Terence J.</creatorcontrib><creatorcontrib>McGinniss, Mary H.</creatorcontrib><creatorcontrib>Klotz, Francis W.</creatorcontrib><creatorcontrib>Miller, Louis H.</creatorcontrib><title>Invasion of Erythrocytes by Plasmodium falciparum Malaria Parasites: Evidence for Receptor Heterogeneity and Two Receptors</title><title>Blood</title><addtitle>Blood</addtitle><description>Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuramin-idase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand.</description><subject>Binding Sites</subject><subject>Biochemistry. Physiology. Immunology. Molecular biology</subject><subject>Biological and medical sciences</subject><subject>Erythrocyte Membrane - physiology</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - parasitology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human protozoal diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Malaria</subject><subject>Medical sciences</subject><subject>Neuraminidase - metabolism</subject><subject>Parasitic diseases</subject><subject>Plasmodium falciparum - pathogenicity</subject><subject>Protozoa</subject><subject>Protozoal diseases</subject><subject>Sialic Acids - blood</subject><subject>Tropical medicine</subject><subject>Trypsin - metabolism</subject><issn>0006-4971</issn><issn>1528-0020</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKkvhJ1TyAXHLYjuxE3NBqFpopVZUqHC1JvYYjLLxYme3Cr8e74f2ymU80vvMePQQcsXZkvNOvO-HGN3yh2qXcskl14fyjCy4FF3FmGDPyYIxpqpGt_wleZXzb8Z4Uwt5QS5qyZWQekH-3o47yCGONHq6SvP0K0U7T5hpP9OHAfI6urBdUw-DDRtIpb2HAVIA-gCpTBb0A13tgsPRIvUx0W9ocTOV5gYnTPEnjhimmcLo6ONTPMf5NXlRtmZ8c3ovyffPq8frm-ru65fb6093lS1X6spKrXSvXVezVnhVNzVo75lUUqNyvXKd7J2XANIL5EL3nXBOAPbYMseVrS_Ju-PeTYp_tpgnsw7Z4jDAiHGbTas6VhdhBZRH0KaYc0JvNimsIc2GM7N3bg7OTXFupNnrPpQyd3X6YNuv0Z2nTpJL_vaUQ7Yw-ASjDfmMtVoI3jQF-3jEsMjYBUwm27C36kJCOxkXw38O-Qf5N6My</recordid><startdate>198605</startdate><enddate>198605</enddate><creator>Mitchell, Graham H.</creator><creator>Hadley, Terence J.</creator><creator>McGinniss, Mary H.</creator><creator>Klotz, Francis W.</creator><creator>Miller, Louis H.</creator><general>Elsevier Inc</general><general>The Americain Society of Hematology</general><scope>6I.</scope><scope>AAFTH</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198605</creationdate><title>Invasion of Erythrocytes by Plasmodium falciparum Malaria Parasites: Evidence for Receptor Heterogeneity and Two Receptors</title><author>Mitchell, Graham H. ; Hadley, Terence J. ; McGinniss, Mary H. ; Klotz, Francis W. ; Miller, Louis H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3519-c5969b9d83072f6343a9ff05659e6db6d85bdf5aa5f2e129b82dd2aebe70d16c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Binding Sites</topic><topic>Biochemistry. Physiology. Immunology. Molecular biology</topic><topic>Biological and medical sciences</topic><topic>Erythrocyte Membrane - physiology</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - parasitology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human protozoal diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Malaria</topic><topic>Medical sciences</topic><topic>Neuraminidase - metabolism</topic><topic>Parasitic diseases</topic><topic>Plasmodium falciparum - pathogenicity</topic><topic>Protozoa</topic><topic>Protozoal diseases</topic><topic>Sialic Acids - blood</topic><topic>Tropical medicine</topic><topic>Trypsin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mitchell, Graham H.</creatorcontrib><creatorcontrib>Hadley, Terence J.</creatorcontrib><creatorcontrib>McGinniss, Mary H.</creatorcontrib><creatorcontrib>Klotz, Francis W.</creatorcontrib><creatorcontrib>Miller, Louis H.</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Blood</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mitchell, Graham H.</au><au>Hadley, Terence J.</au><au>McGinniss, Mary H.</au><au>Klotz, Francis W.</au><au>Miller, Louis H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Invasion of Erythrocytes by Plasmodium falciparum Malaria Parasites: Evidence for Receptor Heterogeneity and Two Receptors</atitle><jtitle>Blood</jtitle><addtitle>Blood</addtitle><date>1986-05</date><risdate>1986</risdate><volume>67</volume><issue>5</issue><spage>1519</spage><epage>1521</epage><pages>1519-1521</pages><issn>0006-4971</issn><eissn>1528-0020</eissn><abstract>Plasmodium falciparum malaria parasites with different capabilities of invading sialic acid-deficient erythrocytes were identified. Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated and Tn erythrocytes twice as efficiently as Thai-2 parasites cultured in normal erythrocytes and seven to ten times more efficiently than a cloned line of Camp parasites cultured in normal erythrocytes. All three parasite lines required sialic acid for optimal invasion, but Thai-2 parasites cultured in Tn erythrocytes invaded neuraminidase-treated erythrocytes with 45% efficiency whereas Camp parasites invaded neuramin-idase-treated erythrocytes with less than 10% efficiency. P falciparum malaria parasites probably possess two receptors: one that binds to a sialic acid-dependent ligand and another that binds to a sialic acid-independent ligand. Parasites may differ in the quantity or affinity of their receptors for the sialic acid-independent ligand.</abstract><cop>Washington, DC</cop><pub>Elsevier Inc</pub><pmid>3516259</pmid><doi>10.1182/blood.V67.5.1519.1519</doi><tpages>3</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Blood, 1986-05, Vol.67 (5), p.1519-1521 |
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| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Binding Sites Biochemistry. Physiology. Immunology. Molecular biology Biological and medical sciences Erythrocyte Membrane - physiology Erythrocytes - metabolism Erythrocytes - parasitology Fundamental and applied biological sciences. Psychology Human protozoal diseases Humans Infectious diseases Malaria Medical sciences Neuraminidase - metabolism Parasitic diseases Plasmodium falciparum - pathogenicity Protozoa Protozoal diseases Sialic Acids - blood Tropical medicine Trypsin - metabolism |
| title | Invasion of Erythrocytes by Plasmodium falciparum Malaria Parasites: Evidence for Receptor Heterogeneity and Two Receptors |
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