Solution structure of a specific DNA complex of the Myb DNA-binding domain with cooperative recognition helices

The DNA-binding region of Myb consists of three imperfect tandem repeats (R1, R2, and R3). We have determined the solution structure of a specific DNA complex of the minimum DNA-binding domain (R2R3) by heteronuclear multidimensional NMR. Both R2 and R3 contain three helices, and the third helix in...

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Veröffentlicht in:	Cell 1994-11, Vol.79 (4), p.639-648
Hauptverfasser:	Ogata, Kazuhiro, Morikawa, Souichi, Nakamura, Haruki, Sekikawa, Ai, Inoue, Taiko, Kanai, Hiroko, Sarai, Akinori, Ishii, Shunsuke, Nishimura, Yoshifumi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Base Composition Binding Sites DNA - chemistry DNA - metabolism DNA-Binding Proteins - chemistry DNA-Binding Proteins - metabolism Drosophila - metabolism Humans Magnetic Resonance Spectroscopy Models, Molecular Molecular Sequence Data Nucleic Acid Conformation Oligodeoxyribonucleotides - chemistry Oligodeoxyribonucleotides - metabolism Protein Conformation Protein Structure, Secondary Proto-Oncogene Proteins - chemistry Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-myb Saccharomyces cerevisiae - metabolism Sequence Homology, Amino Acid Zea mays - metabolism Zinc Fingers
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