Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine
This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a...
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| Veröffentlicht in: | Journal of clinical pharmacology 1986-05, Vol.26 (5), p.372-377 |
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| container_title | Journal of clinical pharmacology |
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| creator | Cate, Emily W. Rogers, John F. Powell, J. Robert |
| description | This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a crossover fashion: cimetidine 1,200 mg/d, ranitidine 300 mg/d, and placebo. Cimetidine significantly increased the tolbutamide area under the plasma concentration‐time curve by 20% (range, −5% to 42%), increased the elimination half‐life by 17%, and decreased the carboxytolbutamide:tolbutamide plasma ratio from 0.042 to 0.036. Ranitidine did not significantly alter tolbutamide pharmacokinetics. |
| doi_str_mv | 10.1002/j.1552-4604.1986.tb03540.x |
| format | Article |
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Robert</creator><creatorcontrib>Cate, Emily W. ; Rogers, John F. ; Powell, J. Robert</creatorcontrib><description>This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a crossover fashion: cimetidine 1,200 mg/d, ranitidine 300 mg/d, and placebo. Cimetidine significantly increased the tolbutamide area under the plasma concentration‐time curve by 20% (range, −5% to 42%), increased the elimination half‐life by 17%, and decreased the carboxytolbutamide:tolbutamide plasma ratio from 0.042 to 0.036. Ranitidine did not significantly alter tolbutamide pharmacokinetics.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/j.1552-4604.1986.tb03540.x</identifier><identifier>PMID: 3700691</identifier><identifier>CODEN: JCPCBR</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Blood Glucose - analysis ; Chromatography, High Pressure Liquid ; Cimetidine - pharmacology ; Double-Blind Method ; Half-Life ; Histamine and antagonists. Allergy ; Humans ; Male ; Medical sciences ; Pharmacology. 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Robert</creatorcontrib><title>Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a crossover fashion: cimetidine 1,200 mg/d, ranitidine 300 mg/d, and placebo. Cimetidine significantly increased the tolbutamide area under the plasma concentration‐time curve by 20% (range, −5% to 42%), increased the elimination half‐life by 17%, and decreased the carboxytolbutamide:tolbutamide plasma ratio from 0.042 to 0.036. Ranitidine did not significantly alter tolbutamide pharmacokinetics.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Blood Glucose - analysis</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Cimetidine - pharmacology</subject><subject>Double-Blind Method</subject><subject>Half-Life</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Ranitidine - pharmacology</subject><subject>Tolbutamide - analogs & derivatives</subject><subject>Tolbutamide - blood</subject><subject>Tolbutamide - metabolism</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkM1O3DAUhS1EBVPaR0CKEGKX9N7YsRNWoIi_CihUIJaWndjCQ36GOKPOvH2TJpp9V7bu-e6x9RFyghAhQPxjGWGSxCHjwCLMUh71GmjCINrskcUu2icLgAzDWAAckq_eLwGQswQPyAEdZjzDBbm-a96ddr1rm6C1wUtb6XWvalea4KpytWvUv0hvg9zVpnela0wwIEHT9sFv1bhp9I18sary5vt8HpHX66uX_Da8_3Vzl1_ehwWjKYQ0RR2rmIO2LOZWlJpxUxRloUuh0PAEStCCGUyoziiYrFQWOWBqYxDUanpEzqbeVdd-ro3vZe18YapKNaZdeyl4Cog8HsDzCSy61vvOWLnqXK26rUSQo0S5lKMpOZqSo0Q5S5SbYfl4fmWta1PuVmdrQ34658oXqrKdagrnd5hI05QKNmAXE_bHVWb7Hx-QP_On2_E6VIRThfO92ewqVPchuaAikW-PN5I-CED6nEukfwFWF52N</recordid><startdate>198605</startdate><enddate>198605</enddate><creator>Cate, Emily W.</creator><creator>Rogers, John F.</creator><creator>Powell, J. 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Robert</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4380-381b2a260bf426f7db46eccdcbd7a1e650d0b74e153b930e9daf16018f2073fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Blood Glucose - analysis</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Cimetidine - pharmacology</topic><topic>Double-Blind Method</topic><topic>Half-Life</topic><topic>Histamine and antagonists. Allergy</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Ranitidine - pharmacology</topic><topic>Tolbutamide - analogs & derivatives</topic><topic>Tolbutamide - blood</topic><topic>Tolbutamide - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cate, Emily W.</creatorcontrib><creatorcontrib>Rogers, John F.</creatorcontrib><creatorcontrib>Powell, J. Robert</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cate, Emily W.</au><au>Rogers, John F.</au><au>Powell, J. Robert</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>1986-05</date><risdate>1986</risdate><volume>26</volume><issue>5</issue><spage>372</spage><epage>377</epage><pages>372-377</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><coden>JCPCBR</coden><abstract>This study was designed to compare the effects of equivalent therapeutic doses of two H2 antagonists, cimetidine and ranitidine, on tolbutamide pharmacokinetics. Twelve healthy men were given a 1‐g oral dose of tolbutamide on three occasions. Subjects were randomly assigned to three treatments in a crossover fashion: cimetidine 1,200 mg/d, ranitidine 300 mg/d, and placebo. Cimetidine significantly increased the tolbutamide area under the plasma concentration‐time curve by 20% (range, −5% to 42%), increased the elimination half‐life by 17%, and decreased the carboxytolbutamide:tolbutamide plasma ratio from 0.042 to 0.036. Ranitidine did not significantly alter tolbutamide pharmacokinetics.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>3700691</pmid><doi>10.1002/j.1552-4604.1986.tb03540.x</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0091-2700 |
| ispartof | Journal of clinical pharmacology, 1986-05, Vol.26 (5), p.372-377 |
| issn | 0091-2700 1552-4604 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Biological and medical sciences Blood Glucose - analysis Chromatography, High Pressure Liquid Cimetidine - pharmacology Double-Blind Method Half-Life Histamine and antagonists. Allergy Humans Male Medical sciences Pharmacology. Drug treatments Ranitidine - pharmacology Tolbutamide - analogs & derivatives Tolbutamide - blood Tolbutamide - metabolism |
| title | Inhibition of Tolbutamide Elimination by Cimetidine but not Ranitidine |
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