Effects of bicuculline on inspiratory activities in piglets
Antagonism of the α receptor sub-type at γ-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABA A receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-in...
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| Veröffentlicht in: | Brain research 1994-07, Vol.650 (1), p.166-169 |
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| creator | Steele, Andrew M. Siddiqi, Zafar A. Sica, Anthony L. |
| description | Antagonism of the α receptor sub-type at γ-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABA
A receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect on discharge amplitude was manifested in autopower spectra as an increase in the power of peaks located in the medium-frequency (10–50 Hz) band. More importantly, coherence estimates were increased by bicuculline administration demonstrating GABA-mediated influences on a central pattern generator with output in the 10–50 Hz band. |
| doi_str_mv | 10.1016/0006-8993(94)90222-4 |
| format | Article |
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A receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect on discharge amplitude was manifested in autopower spectra as an increase in the power of peaks located in the medium-frequency (10–50 Hz) band. More importantly, coherence estimates were increased by bicuculline administration demonstrating GABA-mediated influences on a central pattern generator with output in the 10–50 Hz band.</description><subject>Animals</subject><subject>Animals, Newborn</subject><subject>Bicuculline</subject><subject>Bicuculline - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Central pattern generator</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hypoglossal</subject><subject>Hypoglossal Nerve - drug effects</subject><subject>Medium-frequency oscillation</subject><subject>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</subject><subject>Phrenic</subject><subject>Phrenic Nerve - drug effects</subject><subject>Piglet</subject><subject>Respiration - drug effects</subject><subject>Swine</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLAzEQgIMotT7-gcIeRPSwmvcDQZBSHyB48R6y2VmJbHdrsiv035va0qOehpn5Zph8QeiM4BuCibzFGMtSG8OuDL82mFJa8j00JVrRUlKO99F0hxyio5Q-c8qYwRM0UUYwqfAU3c2bBvyQir4pquBHP7Zt6KDouyJ0aRmiG_q4KpwfwncYAqRcLpbho4UhnaCDxrUJTrfxGL0_zt9nz-Xr29PL7OG19JyooaRe1BygJpoIR3iDoamF5sx7irnWhtWVM1TJSlfANRVMKCZdBVLWWuT0GF1u1i5j_zVCGuwiJA9t6zrox2SV1PmZTP8LEikUVoJnkG9AH_uUIjR2GcPCxZUl2K7d2rU4uxZnDbe_bu167Hy7f6wWUO-GtjJz_2Lbd8m7tomu8yHtME6IMYpk7H6DQXb2HSDa5AN0HuoQ81fYug9_3_ED0ZiUDg</recordid><startdate>19940704</startdate><enddate>19940704</enddate><creator>Steele, Andrew M.</creator><creator>Siddiqi, Zafar A.</creator><creator>Sica, Anthony L.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19940704</creationdate><title>Effects of bicuculline on inspiratory activities in piglets</title><author>Steele, Andrew M. ; Siddiqi, Zafar A. ; Sica, Anthony L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-2c5d4eed1815a14f0efd5843cc2048893dba9276b8be482535736abe66d85253</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Bicuculline</topic><topic>Bicuculline - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Central pattern generator</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hypoglossal</topic><topic>Hypoglossal Nerve - drug effects</topic><topic>Medium-frequency oscillation</topic><topic>Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration</topic><topic>Phrenic</topic><topic>Phrenic Nerve - drug effects</topic><topic>Piglet</topic><topic>Respiration - drug effects</topic><topic>Swine</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Steele, Andrew M.</creatorcontrib><creatorcontrib>Siddiqi, Zafar A.</creatorcontrib><creatorcontrib>Sica, Anthony L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Steele, Andrew M.</au><au>Siddiqi, Zafar A.</au><au>Sica, Anthony L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of bicuculline on inspiratory activities in piglets</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1994-07-04</date><risdate>1994</risdate><volume>650</volume><issue>1</issue><spage>166</spage><epage>169</epage><pages>166-169</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>Antagonism of the α receptor sub-type at γ-aminobutyric acid (GABA) recognition sites in developing pigs was evaluated using the GABA
A receptor antagonist bicuculline. The effect of bicuculline infusions was to produce an increase of phrenic and hypoglossal discharge amplitudes. This bicuculline-induced effect on discharge amplitude was manifested in autopower spectra as an increase in the power of peaks located in the medium-frequency (10–50 Hz) band. More importantly, coherence estimates were increased by bicuculline administration demonstrating GABA-mediated influences on a central pattern generator with output in the 10–50 Hz band.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>7953670</pmid><doi>10.1016/0006-8993(94)90222-4</doi><tpages>4</tpages></addata></record> |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals Animals, Newborn Bicuculline Bicuculline - pharmacology Biological and medical sciences Central pattern generator Fundamental and applied biological sciences. Psychology Hypoglossal Hypoglossal Nerve - drug effects Medium-frequency oscillation Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration Phrenic Phrenic Nerve - drug effects Piglet Respiration - drug effects Swine Vertebrates: nervous system and sense organs |
| title | Effects of bicuculline on inspiratory activities in piglets |
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