A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens
A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermato-genesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically d...
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| Veröffentlicht in: | Human molecular genetics 1994-06, Vol.3 (6), p.873-878 |
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| container_title | Human molecular genetics |
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| creator | Agulnik, Alexander I. Mitchell, Michael J. Lerner, Jody L. Woods, Diane R. Bishop, Colin E. |
| description | A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermato-genesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically detected male antigen SDMA. Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY. |
| doi_str_mv | 10.1093/hmg/3.6.873 |
| format | Article |
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Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. 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Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Artificial, Yeast</subject><subject>DNA - genetics</subject><subject>DNA Primers</subject><subject>Female</subject><subject>Gene Expression - genetics</subject><subject>H-Y Antigen - biosynthesis</subject><subject>H-Y Antigen - genetics</subject><subject>Humans</subject><subject>Male</subject><subject>Mice - genetics</subject><subject>Molecular Sequence Data</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Restriction Mapping</subject><subject>RNA-Directed DNA Polymerase</subject><subject>Sequence Deletion</subject><subject>Sequence Homology, Amino Acid</subject><subject>Sex Characteristics</subject><subject>Spermatogenesis - genetics</subject><subject>Testis - metabolism</subject><subject>Y Chromosome</subject><issn>0964-6906</issn><issn>1460-2083</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1rGzEQhkVpSZ20p54LOvVS1tHXStpjMKkdCBRKCmkvQtaObLWr1VZaQ_Ij-p8rY5NrT3N4n3lg5kXoAyVLSjp-vY-7a76US634K7SgQpKGEc1fowXppGhkR-RbdFnKL0KoFFxdoAvVMtFRtkB_b3BMhwL4B3b7nGIqKQLewQgYRpd66PH2GVucYRfSiKEUGOdgB-xTxmWCHO2cjngJBduxx_A05Uod4eRxtAM0FXPBB4djGOvWPpQ5uRQnO4dtGMJc_dVZJeUdeuPtUOD9eV6h719uH1ab5v7r-m51c984Qbu5YYJz4lsmqdM97bVwRLe0o7bniivNeU-YBe1bCp1mkmsn3dYr6hT3SnDNr9Cnk3fK6c8BymxiKA6GwY5Qv2GU1IQw0f4XpFJypoSq4OcT6HIqJYM3Uw7R5mdDiTm2ZGpLhhtpakuV_njWHrYR-hf2XEvNm1NeXwVPL7HNv42sF7Zm8_jTrOl68_ht82BW_B-Ec573</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Agulnik, Alexander I.</creator><creator>Mitchell, Michael J.</creator><creator>Lerner, Jody L.</creator><creator>Woods, Diane R.</creator><creator>Bishop, Colin E.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens</title><author>Agulnik, Alexander I. ; Mitchell, Michael J. ; Lerner, Jody L. ; Woods, Diane R. ; Bishop, Colin E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c419t-24330f5261c8d1d84c085191ad3737833d02ae8f51e982638c6cbf71c73f74383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Artificial, Yeast</topic><topic>DNA - genetics</topic><topic>DNA Primers</topic><topic>Female</topic><topic>Gene Expression - genetics</topic><topic>H-Y Antigen - biosynthesis</topic><topic>H-Y Antigen - genetics</topic><topic>Humans</topic><topic>Male</topic><topic>Mice - genetics</topic><topic>Molecular Sequence Data</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Restriction Mapping</topic><topic>RNA-Directed DNA Polymerase</topic><topic>Sequence Deletion</topic><topic>Sequence Homology, Amino Acid</topic><topic>Sex Characteristics</topic><topic>Spermatogenesis - genetics</topic><topic>Testis - metabolism</topic><topic>Y Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Agulnik, Alexander I.</creatorcontrib><creatorcontrib>Mitchell, Michael J.</creatorcontrib><creatorcontrib>Lerner, Jody L.</creatorcontrib><creatorcontrib>Woods, Diane R.</creatorcontrib><creatorcontrib>Bishop, Colin E.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Human molecular genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Agulnik, Alexander I.</au><au>Mitchell, Michael J.</au><au>Lerner, Jody L.</au><au>Woods, Diane R.</au><au>Bishop, Colin E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens</atitle><jtitle>Human molecular genetics</jtitle><addtitle>Hum Mol Genet</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>3</volume><issue>6</issue><spage>873</spage><epage>878</epage><pages>873-878</pages><issn>0964-6906</issn><eissn>1460-2083</eissn><abstract>A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermato-genesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically detected male antigen SDMA. Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY.</abstract><cop>England</cop><pub>Oxford University Press</pub><pmid>7524912</pmid><doi>10.1093/hmg/3.6.873</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0964-6906 |
| ispartof | Human molecular genetics, 1994-06, Vol.3 (6), p.873-878 |
| issn | 0964-6906 1460-2083 |
| language | eng |
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| source | MEDLINE; Oxford University Press Archive |
| subjects | Amino Acid Sequence Animals Base Sequence Chromosome Mapping Chromosomes, Artificial, Yeast DNA - genetics DNA Primers Female Gene Expression - genetics H-Y Antigen - biosynthesis H-Y Antigen - genetics Humans Male Mice - genetics Molecular Sequence Data Polymerase Chain Reaction - methods Restriction Mapping RNA-Directed DNA Polymerase Sequence Deletion Sequence Homology, Amino Acid Sex Characteristics Spermatogenesis - genetics Testis - metabolism Y Chromosome |
| title | A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens |
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