Immunoelectron microscopic study of substance P-containing fibers in feline cerebral arteries
The ultrastructure of substance P-containing fibers in feline cerebral arteries was examined by combining substance P immunohistochemistry and electron microscopy. At the light and electron microscopic level, positive fibers were observed in the adventitia and at the border between the adventitia an...
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| Veröffentlicht in: | Brain research 1986-03, Vol.369 (1), p.12-20 |
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| creator | Liu-Chen, Lee-Yuan Liszczak, Theodore M. King, Joan C. Moskowtiz, Michael A. |
| description | The ultrastructure of substance P-containing fibers in feline cerebral arteries was examined by combining substance P immunohistochemistry and electron microscopy. At the light and electron microscopic level, positive fibers were observed in the adventitia and at the border between the adventitia and media, but not within the media or the endothelium. The substance P-containing fibers were unmyelinated with diameters consistent with C-fiber caliber. Positive axons were in close contact with Schwann cell processes. Positive axons contained 24 nm microtubules, 10 nm neurofilaments, clear vesicles and scattered mitochondria. The number of mitochondria and organelles resembling vesicles appeared to increase in presumptive axon terminals. No synaptic membrane specializations were observed. |
| doi_str_mv | 10.1016/0006-8993(86)90508-1 |
| format | Article |
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At the light and electron microscopic level, positive fibers were observed in the adventitia and at the border between the adventitia and media, but not within the media or the endothelium. The substance P-containing fibers were unmyelinated with diameters consistent with C-fiber caliber. Positive axons were in close contact with Schwann cell processes. Positive axons contained 24 nm microtubules, 10 nm neurofilaments, clear vesicles and scattered mitochondria. The number of mitochondria and organelles resembling vesicles appeared to increase in presumptive axon terminals. 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Psychology ; Immunoenzyme Techniques ; immunohistochemistry ; Microscopy, Electron ; Nerve Fibers - metabolism ; sensory nerve fiber ; substance P ; Substance P - metabolism ; ultrastructure ; Vertebrates: nervous system and sense organs</subject><ispartof>Brain research, 1986-03, Vol.369 (1), p.12-20</ispartof><rights>1986 Elsevier Science Publishers B.V. 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At the light and electron microscopic level, positive fibers were observed in the adventitia and at the border between the adventitia and media, but not within the media or the endothelium. The substance P-containing fibers were unmyelinated with diameters consistent with C-fiber caliber. Positive axons were in close contact with Schwann cell processes. Positive axons contained 24 nm microtubules, 10 nm neurofilaments, clear vesicles and scattered mitochondria. The number of mitochondria and organelles resembling vesicles appeared to increase in presumptive axon terminals. No synaptic membrane specializations were observed.</description><subject>Animals</subject><subject>Axons - ultrastructure</subject><subject>Biological and medical sciences</subject><subject>Cats</subject><subject>Cerebral Arteries - innervation</subject><subject>cerebral blood vessel</subject><subject>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Immunoenzyme Techniques</subject><subject>immunohistochemistry</subject><subject>Microscopy, Electron</subject><subject>Nerve Fibers - metabolism</subject><subject>sensory nerve fiber</subject><subject>substance P</subject><subject>Substance P - metabolism</subject><subject>ultrastructure</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVoSTZp_0ECOpTQHtxKtqyPS6GEpgkEmkN6LEKSR0XFljaSXci_j9xd9pichmGeGYbnReicks-UUP6FEMIbqVT3UfJPivRENvQIbagUbcNbRt6gzQE5Qael_K1t1ylyjI5b1lLJ2Ab9vp2mJSYYwc05RTwFl1NxaRscLvMyPOHkcVlsmU10gO8bl-JsQgzxD_bBQi44ROxhDBGwgww2mxGbPEMOUN6ht96MBd7v6xn6df394eqmufv54_bq213jGBVzw3sGSnKpBDjBnLWGdkz21qie2MG33koCykLHBuWggkR4MwzKdpzy3pHuDF3u7m5zelygzHoKxcE4mghpKVpwoZSSr4OUsa5lfAXZDlx1lAxeb3OYTH7SlOhVv17d6tWtllz_169pXbvY31_sBMNhae-7zj_s56Y4M_pcrYZywKRgrRR9xb7uMKjS_gXIurgANYAh5BqUHlJ4-Y9nNMyiIA</recordid><startdate>19860326</startdate><enddate>19860326</enddate><creator>Liu-Chen, Lee-Yuan</creator><creator>Liszczak, Theodore M.</creator><creator>King, Joan C.</creator><creator>Moskowtiz, Michael A.</creator><general>Elsevier B.V</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860326</creationdate><title>Immunoelectron microscopic study of substance P-containing fibers in feline cerebral arteries</title><author>Liu-Chen, Lee-Yuan ; Liszczak, Theodore M. ; King, Joan C. ; Moskowtiz, Michael A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-654e986897ec74cbba13485ba950bdf2fb80e9be34d9ce86807fadd9b36165c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Axons - ultrastructure</topic><topic>Biological and medical sciences</topic><topic>Cats</topic><topic>Cerebral Arteries - innervation</topic><topic>cerebral blood vessel</topic><topic>Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Immunoenzyme Techniques</topic><topic>immunohistochemistry</topic><topic>Microscopy, Electron</topic><topic>Nerve Fibers - metabolism</topic><topic>sensory nerve fiber</topic><topic>substance P</topic><topic>Substance P - metabolism</topic><topic>ultrastructure</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu-Chen, Lee-Yuan</creatorcontrib><creatorcontrib>Liszczak, Theodore M.</creatorcontrib><creatorcontrib>King, Joan C.</creatorcontrib><creatorcontrib>Moskowtiz, Michael A.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu-Chen, Lee-Yuan</au><au>Liszczak, Theodore M.</au><au>King, Joan C.</au><au>Moskowtiz, Michael A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoelectron microscopic study of substance P-containing fibers in feline cerebral arteries</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-03-26</date><risdate>1986</risdate><volume>369</volume><issue>1</issue><spage>12</spage><epage>20</epage><pages>12-20</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><coden>BRREAP</coden><abstract>The ultrastructure of substance P-containing fibers in feline cerebral arteries was examined by combining substance P immunohistochemistry and electron microscopy. At the light and electron microscopic level, positive fibers were observed in the adventitia and at the border between the adventitia and media, but not within the media or the endothelium. The substance P-containing fibers were unmyelinated with diameters consistent with C-fiber caliber. Positive axons were in close contact with Schwann cell processes. Positive axons contained 24 nm microtubules, 10 nm neurofilaments, clear vesicles and scattered mitochondria. The number of mitochondria and organelles resembling vesicles appeared to increase in presumptive axon terminals. No synaptic membrane specializations were observed.</abstract><cop>London</cop><cop>Amsterdam</cop><cop>New York, NY</cop><pub>Elsevier B.V</pub><pmid>2421844</pmid><doi>10.1016/0006-8993(86)90508-1</doi><tpages>9</tpages></addata></record> |
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| language | eng |
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| subjects | Animals Axons - ultrastructure Biological and medical sciences Cats Cerebral Arteries - innervation cerebral blood vessel Cerebral circulation. Blood-brain barrier. Choroid plexus. Cerebrospinal fluid. Circumventricular organ. Meninges Fundamental and applied biological sciences. Psychology Immunoenzyme Techniques immunohistochemistry Microscopy, Electron Nerve Fibers - metabolism sensory nerve fiber substance P Substance P - metabolism ultrastructure Vertebrates: nervous system and sense organs |
| title | Immunoelectron microscopic study of substance P-containing fibers in feline cerebral arteries |
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