Regulatory changes following kainic acid-induced striatal lesions
Kainic acid-induced lesions (KAL) of the striatum produce body weight and regulatory deficits in the rat. Unlike lateral hypothalamic rats, KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated the...
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| Veröffentlicht in: | Brain research 1986-03, Vol.367 (1), p.314-318 |
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| creator | Sanberg, P.R. Bunsey, M.D. Hagenmeyer-Houser, S.H. Fine, K.E. Hillyer, J.G. Huntsman, C.S. Justice, C.A. McCann, S.A. McCoy, D.L. Monago, J.M. Rose, J.G. |
| description | Kainic acid-induced lesions (KAL) of the striatum produce body weight and regulatory deficits in the rat. Unlike lateral hypothalamic rats, KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated these effects further. As in previous studies, food deprivation was found to cause polydipsia and increased postdeprivational food intake in the KAL animal. Urination and defecation, often used as an index of emotionality, were also found to increase under these conditions. When the antidiuretic hormone vasopressin was injected, all of these differences remained with the exception of postdeprivational feeding — KAL rats no longer ate more than controls. These findings suggest that psychogenic factors — but not hormonal influences — may play a primary role in the regulatory peculiarities seen in the KAL rat. |
| doi_str_mv | 10.1016/0006-8993(86)91609-4 |
| format | Article |
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Unlike lateral hypothalamic rats, KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated these effects further. As in previous studies, food deprivation was found to cause polydipsia and increased postdeprivational food intake in the KAL animal. Urination and defecation, often used as an index of emotionality, were also found to increase under these conditions. When the antidiuretic hormone vasopressin was injected, all of these differences remained with the exception of postdeprivational feeding — KAL rats no longer ate more than controls. These findings suggest that psychogenic factors — but not hormonal influences — may play a primary role in the regulatory peculiarities seen in the KAL rat.</description><identifier>ISSN: 0006-8993</identifier><identifier>EISSN: 1872-6240</identifier><identifier>DOI: 10.1016/0006-8993(86)91609-4</identifier><identifier>PMID: 3697706</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; body weight ; Corpus Striatum - drug effects ; Defecation - drug effects ; Diuresis - drug effects ; Drinking Behavior - drug effects ; Eliminative Behavior, Animal - drug effects ; Emotions - drug effects ; feeding and drinking ; Feeding Behavior - drug effects ; kainic acid ; Kainic Acid - pharmacology ; Male ; Rats ; Rats, Inbred Strains ; striatum ; vasopressin ; Vasopressins - pharmacology</subject><ispartof>Brain research, 1986-03, Vol.367 (1), p.314-318</ispartof><rights>1986 Elsevier Science Publishers B.V. (Biomedical Division)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c388t-6ff15cf99a4a682a11365061435050a7d06eb179bfdcff29dfcdbb57362986123</citedby><cites>FETCH-LOGICAL-c388t-6ff15cf99a4a682a11365061435050a7d06eb179bfdcff29dfcdbb57362986123</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0006-8993(86)91609-4$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3697706$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sanberg, P.R.</creatorcontrib><creatorcontrib>Bunsey, M.D.</creatorcontrib><creatorcontrib>Hagenmeyer-Houser, S.H.</creatorcontrib><creatorcontrib>Fine, K.E.</creatorcontrib><creatorcontrib>Hillyer, J.G.</creatorcontrib><creatorcontrib>Huntsman, C.S.</creatorcontrib><creatorcontrib>Justice, C.A.</creatorcontrib><creatorcontrib>McCann, S.A.</creatorcontrib><creatorcontrib>McCoy, D.L.</creatorcontrib><creatorcontrib>Monago, J.M.</creatorcontrib><creatorcontrib>Rose, J.G.</creatorcontrib><title>Regulatory changes following kainic acid-induced striatal lesions</title><title>Brain research</title><addtitle>Brain Res</addtitle><description>Kainic acid-induced lesions (KAL) of the striatum produce body weight and regulatory deficits in the rat. Unlike lateral hypothalamic rats, KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated these effects further. As in previous studies, food deprivation was found to cause polydipsia and increased postdeprivational food intake in the KAL animal. Urination and defecation, often used as an index of emotionality, were also found to increase under these conditions. When the antidiuretic hormone vasopressin was injected, all of these differences remained with the exception of postdeprivational feeding — KAL rats no longer ate more than controls. These findings suggest that psychogenic factors — but not hormonal influences — may play a primary role in the regulatory peculiarities seen in the KAL rat.</description><subject>Animals</subject><subject>body weight</subject><subject>Corpus Striatum - drug effects</subject><subject>Defecation - drug effects</subject><subject>Diuresis - drug effects</subject><subject>Drinking Behavior - drug effects</subject><subject>Eliminative Behavior, Animal - drug effects</subject><subject>Emotions - drug effects</subject><subject>feeding and drinking</subject><subject>Feeding Behavior - drug effects</subject><subject>kainic acid</subject><subject>Kainic Acid - pharmacology</subject><subject>Male</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>striatum</subject><subject>vasopressin</subject><subject>Vasopressins - pharmacology</subject><issn>0006-8993</issn><issn>1872-6240</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtKAzEUhoMotVbfQGFWoovRZDKTy0aQ4g0Kgug6ZHKp0XRSkxmlb29qi0tdHQ7_d84PHwDHCF4giMglhJCUjHN8xsg5RwTyst4BY8RoVZKqhrtg_Ivsg4OU3vKKMYcjMMKEUwrJGFw_mfngZR_iqlCvspubVNjgffhy3bx4l65zqpDK6dJ1elBGF6mPTvbSF94kF7p0CPas9MkcbecEvNzePE_vy9nj3cP0elYqzFhfEmtRoyznspaEVRIhTBpIUI0b2EBJNSSmRZS3VitrK66t0m3bUEwqzgiq8AScbv4uY_gYTOrFwiVlvJedCUMSlFDOM_8vmCs55BXNYL0BVQwpRWPFMrqFjCuBoFgrFmt_Yu1PMCJ-FIs6n51s_w_twujfo63TnF9tcpNtfDoTRVLOdNmdi0b1Qgf3d8E3z3aKfQ</recordid><startdate>19860305</startdate><enddate>19860305</enddate><creator>Sanberg, P.R.</creator><creator>Bunsey, M.D.</creator><creator>Hagenmeyer-Houser, S.H.</creator><creator>Fine, K.E.</creator><creator>Hillyer, J.G.</creator><creator>Huntsman, C.S.</creator><creator>Justice, C.A.</creator><creator>McCann, S.A.</creator><creator>McCoy, D.L.</creator><creator>Monago, J.M.</creator><creator>Rose, J.G.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19860305</creationdate><title>Regulatory changes following kainic acid-induced striatal lesions</title><author>Sanberg, P.R. ; Bunsey, M.D. ; Hagenmeyer-Houser, S.H. ; Fine, K.E. ; Hillyer, J.G. ; Huntsman, C.S. ; Justice, C.A. ; McCann, S.A. ; McCoy, D.L. ; Monago, J.M. ; Rose, J.G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-6ff15cf99a4a682a11365061435050a7d06eb179bfdcff29dfcdbb57362986123</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>body weight</topic><topic>Corpus Striatum - drug effects</topic><topic>Defecation - drug effects</topic><topic>Diuresis - drug effects</topic><topic>Drinking Behavior - drug effects</topic><topic>Eliminative Behavior, Animal - drug effects</topic><topic>Emotions - drug effects</topic><topic>feeding and drinking</topic><topic>Feeding Behavior - drug effects</topic><topic>kainic acid</topic><topic>Kainic Acid - pharmacology</topic><topic>Male</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>striatum</topic><topic>vasopressin</topic><topic>Vasopressins - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sanberg, P.R.</creatorcontrib><creatorcontrib>Bunsey, M.D.</creatorcontrib><creatorcontrib>Hagenmeyer-Houser, S.H.</creatorcontrib><creatorcontrib>Fine, K.E.</creatorcontrib><creatorcontrib>Hillyer, J.G.</creatorcontrib><creatorcontrib>Huntsman, C.S.</creatorcontrib><creatorcontrib>Justice, C.A.</creatorcontrib><creatorcontrib>McCann, S.A.</creatorcontrib><creatorcontrib>McCoy, D.L.</creatorcontrib><creatorcontrib>Monago, J.M.</creatorcontrib><creatorcontrib>Rose, J.G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sanberg, P.R.</au><au>Bunsey, M.D.</au><au>Hagenmeyer-Houser, S.H.</au><au>Fine, K.E.</au><au>Hillyer, J.G.</au><au>Huntsman, C.S.</au><au>Justice, C.A.</au><au>McCann, S.A.</au><au>McCoy, D.L.</au><au>Monago, J.M.</au><au>Rose, J.G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Regulatory changes following kainic acid-induced striatal lesions</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1986-03-05</date><risdate>1986</risdate><volume>367</volume><issue>1</issue><spage>314</spage><epage>318</epage><pages>314-318</pages><issn>0006-8993</issn><eissn>1872-6240</eissn><abstract>Kainic acid-induced lesions (KAL) of the striatum produce body weight and regulatory deficits in the rat. Unlike lateral hypothalamic rats, KAL rats drink more during food deprivation and eat more afterwards as compared to both baseline conditions and control rats. The present study investigated these effects further. As in previous studies, food deprivation was found to cause polydipsia and increased postdeprivational food intake in the KAL animal. Urination and defecation, often used as an index of emotionality, were also found to increase under these conditions. When the antidiuretic hormone vasopressin was injected, all of these differences remained with the exception of postdeprivational feeding — KAL rats no longer ate more than controls. These findings suggest that psychogenic factors — but not hormonal influences — may play a primary role in the regulatory peculiarities seen in the KAL rat.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>3697706</pmid><doi>10.1016/0006-8993(86)91609-4</doi><tpages>5</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Animals body weight Corpus Striatum - drug effects Defecation - drug effects Diuresis - drug effects Drinking Behavior - drug effects Eliminative Behavior, Animal - drug effects Emotions - drug effects feeding and drinking Feeding Behavior - drug effects kainic acid Kainic Acid - pharmacology Male Rats Rats, Inbred Strains striatum vasopressin Vasopressins - pharmacology |
| title | Regulatory changes following kainic acid-induced striatal lesions |
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