Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase
A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with 123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1–4 years after removal of the primary tumour....
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| Veröffentlicht in: | Clinical radiology 1986-03, Vol.37 (2), p.107-112 |
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| container_title | Clinical radiology |
| container_volume | 37 |
| creator | Critchley, M. Brownless, S. Patten, M. McLaughlin, P.J. Tromans, P.M. McDicken, I.W. Johnson, P.M. |
| description | A murine monoclonal antibody, H317, specific for placental-type alkaline phosphatase was labelled with
123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1–4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) ‘cold’ areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly ‘cold’ areas. Findings were confirmed, where possible, at surgery. |
| doi_str_mv | 10.1016/S0009-9260(86)80373-7 |
| format | Article |
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123I and assessed as an imaging agent using a gamma camera computer system in 18 patients suspected of possible recurrent or metastatic ovarian cancer 1–4 years after removal of the primary tumour. Four patterns of distribution were visible: (1) normal uptake; (2) focal accumulation; (3) diffuse uptake; and (4) ‘cold’ areas. Six patients, five of whom were clinically negative for ovarian cancer, had normal scans; 11 patients, eight of whom were clinically positive, had increased uptake. One patient had visibly ‘cold’ areas. Findings were confirmed, where possible, at surgery.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>3698490</pmid><doi>10.1016/S0009-9260(86)80373-7</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0009-9260 |
| ispartof | Clinical radiology, 1986-03, Vol.37 (2), p.107-112 |
| issn | 0009-9260 1365-229X |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Aged Alkaline Phosphatase - immunology Antibodies, Monoclonal Carcinoma - enzymology Female GPI-Linked Proteins Humans Iodine Radioisotopes Isoenzymes - immunology Middle Aged Ovarian Neoplasms - diagnostic imaging Ovarian Neoplasms - enzymology Radionuclide Imaging |
| title | Radionuclide imaging of epithelial ovarian tumours with 123I-labelled monoclonal antibody (H317) specific for placental-type alkaline phosphatase |
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