Improved survival in simulated surgical infection with combined cytokine, antibiotic and immunostimulant therapy
A study was performed to find an ideal combination and sequence of cytokines, antibiotics and immunorestorative agents to enhance survival from serious infection. The effects of combinations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), tumour necrosis factor (TNF) a, the immune adju...
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| Veröffentlicht in: | British journal of surgery 1994-09, Vol.81 (9), p.1309-1311 |
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| container_title | British journal of surgery |
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| creator | Gaar, E. Naziri, W. Cheadle, W. G. Pietsch, J. D. Johnson, M. Polk Jr, H. C. |
| description | A study was performed to find an ideal combination and sequence of cytokines, antibiotics and immunorestorative agents to enhance survival from serious infection. The effects of combinations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), tumour necrosis factor (TNF) a, the immune adjuvant muramyl dipeptide (MDP) and two systemic antibiotics were studied in a validated murine model of surgical infection. A single cotton suture containing absorbed Klebsiella pneumoniae was placed into the thighs of mice to produce local and systemic infection. Control mice received a volume of subcutaneous saline equal to that of the therapeutic agent; only 18 per cent survived 9 days after infection. The survival time of mice treated with any single agent was similar to that of controls. The group given maximal combined therapy (65 mice) received GM‐CSF, TNF‐a, MDP, and ampicillinsulbactam or cefoxitin for 6 days. The survival rate in this group 9 days after the introduction of infection was 84–90 per cent (P< 0·0001), suggesting that specific combinations of cytokines, immunostimulants and antibiotics may be useful in combating lethal infection. |
| doi_str_mv | 10.1002/bjs.1800810915 |
| format | Article |
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G.</creatorcontrib><creatorcontrib>Pietsch, J. D.</creatorcontrib><creatorcontrib>Johnson, M.</creatorcontrib><creatorcontrib>Polk Jr, H. C.</creatorcontrib><title>Improved survival in simulated surgical infection with combined cytokine, antibiotic and immunostimulant therapy</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>A study was performed to find an ideal combination and sequence of cytokines, antibiotics and immunorestorative agents to enhance survival from serious infection. The effects of combinations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), tumour necrosis factor (TNF) a, the immune adjuvant muramyl dipeptide (MDP) and two systemic antibiotics were studied in a validated murine model of surgical infection. A single cotton suture containing absorbed Klebsiella pneumoniae was placed into the thighs of mice to produce local and systemic infection. Control mice received a volume of subcutaneous saline equal to that of the therapeutic agent; only 18 per cent survived 9 days after infection. The survival time of mice treated with any single agent was similar to that of controls. The group given maximal combined therapy (65 mice) received GM‐CSF, TNF‐a, MDP, and ampicillinsulbactam or cefoxitin for 6 days. The survival rate in this group 9 days after the introduction of infection was 84–90 per cent (P< 0·0001), suggesting that specific combinations of cytokines, immunostimulants and antibiotics may be useful in combating lethal infection.</description><subject>Acetylmuramyl-Alanyl-Isoglutamine - therapeutic use</subject><subject>Ampicillin - therapeutic use</subject><subject>Animals</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacteremia - drug therapy</subject><subject>Bacteremia - mortality</subject><subject>Biological and medical sciences</subject><subject>Cefoxitin - therapeutic use</subject><subject>Drug Therapy, Combination - therapeutic use</subject><subject>Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use</subject><subject>Klebsiella Infections - drug therapy</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Pharmacology. Drug treatments</subject><subject>Sulbactam - therapeutic use</subject><subject>Surgical Wound Infection - mortality</subject><subject>Surgical Wound Infection - therapy</subject><subject>Tumor Necrosis Factor-alpha - therapeutic use</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkTlPAzEQhS0EgnC0dEhbICoWfB8lII5ECApAKS2v1wuGPcLaG8i_x5AoVB7P-97IngfAIYJnCEJ8XryHMyQhlAgqxDbACBHOcoy43AQjCKHIEcFkB-yG8A4hIpDhbbAtFCNE0RGYjZtZ381dmYWhn_u5qTPfZsE3Q23isvvq7V-3cjb6rs2-fHzLbNcUvk2AXcTuI1WnmWmjL3wXvU1lmfmmGdouxL9Rbczim-vNbLEPtipTB3ewOvfAy83189Vdfv94O766uM8t4ZLlkhTWKGytcoLLQrGKlBIbKxhGThSUSl5h40hJpSuMpKUkmGLLFXHcUmvJHjhZzk3f-xxciLrxwbo6vcV1Q9CCC6UwpQk8WoFD0bhSz3rfmH6hVytK-vFKNyEtoupNa31YYxQzCskvppbYl6_dYi0jqH9j0ikm_R-Tvpw8_d-SN196fYjue-01_Yfmggimpw-3mtOn6WRKp5qTH0ybl_0</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>Gaar, E.</creator><creator>Naziri, W.</creator><creator>Cheadle, W. 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C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3685-83bca92cc9e768b95f3d82ac7521e7b4486f2ae3d48eba84d83242c693e6c4cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Acetylmuramyl-Alanyl-Isoglutamine - therapeutic use</topic><topic>Ampicillin - therapeutic use</topic><topic>Animals</topic><topic>Antibacterial agents</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Bacteremia - drug therapy</topic><topic>Bacteremia - mortality</topic><topic>Biological and medical sciences</topic><topic>Cefoxitin - therapeutic use</topic><topic>Drug Therapy, Combination - therapeutic use</topic><topic>Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use</topic><topic>Klebsiella Infections - drug therapy</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Pharmacology. Drug treatments</topic><topic>Sulbactam - therapeutic use</topic><topic>Surgical Wound Infection - mortality</topic><topic>Surgical Wound Infection - therapy</topic><topic>Tumor Necrosis Factor-alpha - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gaar, E.</creatorcontrib><creatorcontrib>Naziri, W.</creatorcontrib><creatorcontrib>Cheadle, W. G.</creatorcontrib><creatorcontrib>Pietsch, J. D.</creatorcontrib><creatorcontrib>Johnson, M.</creatorcontrib><creatorcontrib>Polk Jr, H. 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C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Improved survival in simulated surgical infection with combined cytokine, antibiotic and immunostimulant therapy</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1994-09</date><risdate>1994</risdate><volume>81</volume><issue>9</issue><spage>1309</spage><epage>1311</epage><pages>1309-1311</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>A study was performed to find an ideal combination and sequence of cytokines, antibiotics and immunorestorative agents to enhance survival from serious infection. The effects of combinations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), tumour necrosis factor (TNF) a, the immune adjuvant muramyl dipeptide (MDP) and two systemic antibiotics were studied in a validated murine model of surgical infection. A single cotton suture containing absorbed Klebsiella pneumoniae was placed into the thighs of mice to produce local and systemic infection. Control mice received a volume of subcutaneous saline equal to that of the therapeutic agent; only 18 per cent survived 9 days after infection. The survival time of mice treated with any single agent was similar to that of controls. The group given maximal combined therapy (65 mice) received GM‐CSF, TNF‐a, MDP, and ampicillinsulbactam or cefoxitin for 6 days. The survival rate in this group 9 days after the introduction of infection was 84–90 per cent (P< 0·0001), suggesting that specific combinations of cytokines, immunostimulants and antibiotics may be useful in combating lethal infection.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>7953394</pmid><doi>10.1002/bjs.1800810915</doi><tpages>3</tpages></addata></record> |
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| ispartof | British journal of surgery, 1994-09, Vol.81 (9), p.1309-1311 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Acetylmuramyl-Alanyl-Isoglutamine - therapeutic use Ampicillin - therapeutic use Animals Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacteremia - drug therapy Bacteremia - mortality Biological and medical sciences Cefoxitin - therapeutic use Drug Therapy, Combination - therapeutic use Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Klebsiella Infections - drug therapy Medical sciences Mice Pharmacology. Drug treatments Sulbactam - therapeutic use Surgical Wound Infection - mortality Surgical Wound Infection - therapy Tumor Necrosis Factor-alpha - therapeutic use |
| title | Improved survival in simulated surgical infection with combined cytokine, antibiotic and immunostimulant therapy |
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