Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor
Contralateral biopsies from 1810 consecutive patients with testicular germ-cell tumor were examined immunohistologically by staining for placental alkaline phosphatase. Contralateral testicular intraepithelial neoplasia (TIN; carcinoma in situ) was found in 89 patients (4.9%; 95% confidence interval...
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| Veröffentlicht in: | World journal of urology 1994-06, Vol.12 (3), p.131-135 |
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| description | Contralateral biopsies from 1810 consecutive patients with testicular germ-cell tumor were examined immunohistologically by staining for placental alkaline phosphatase. Contralateral testicular intraepithelial neoplasia (TIN; carcinoma in situ) was found in 89 patients (4.9%; 95% confidence interval, 3.9%-5.9%). Testicular atrophy was present in 45.9% of patients with TIN and in 13.1% of those without TIN (P < 0.01). There was a history of cryptorchidism in 16.2% of patients with TIN versus only 8.5% of those without TIN (P < 0.05). Patients with contralateral TIN presented at an earlier age (30.8 versus 33.3 years). In all, 23 patients with contralateral TIN had no specific risk marker. In 14 patients with contralateral TIN who had received local radiotherapy of 18-20 Gy to the testis, rebiopsy revealed the disappearance of TIN in all cases. Serum testosterone levels were within or above the normal range in 7 of 13 patients examined after local radiotherapy. Of 9 patients with contralateral TIN who had received chemotherapy, 2 were shown to have persistent TIN at rebiopsy. We conclude that all patients with testicular germ-cell tumor should be offered a contralateral biopsy. Local radiotherapy of the testis is the treatment of choice in patients with contralateral TIN. |
| doi_str_mv | 10.1007/BF00192269 |
| format | Article |
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Contralateral testicular intraepithelial neoplasia (TIN; carcinoma in situ) was found in 89 patients (4.9%; 95% confidence interval, 3.9%-5.9%). Testicular atrophy was present in 45.9% of patients with TIN and in 13.1% of those without TIN (P < 0.01). There was a history of cryptorchidism in 16.2% of patients with TIN versus only 8.5% of those without TIN (P < 0.05). Patients with contralateral TIN presented at an earlier age (30.8 versus 33.3 years). In all, 23 patients with contralateral TIN had no specific risk marker. In 14 patients with contralateral TIN who had received local radiotherapy of 18-20 Gy to the testis, rebiopsy revealed the disappearance of TIN in all cases. Serum testosterone levels were within or above the normal range in 7 of 13 patients examined after local radiotherapy. Of 9 patients with contralateral TIN who had received chemotherapy, 2 were shown to have persistent TIN at rebiopsy. We conclude that all patients with testicular germ-cell tumor should be offered a contralateral biopsy. Local radiotherapy of the testis is the treatment of choice in patients with contralateral TIN.</description><identifier>ISSN: 0724-4983</identifier><identifier>EISSN: 1433-8726</identifier><identifier>DOI: 10.1007/BF00192269</identifier><identifier>PMID: 7951338</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Age Factors ; Antineoplastic Combined Chemotherapy Protocols - therapeutic use ; Austria ; Biomarkers, Tumor - metabolism ; Biopsy ; Carcinoma in Situ - drug therapy ; Carcinoma in Situ - metabolism ; Carcinoma in Situ - pathology ; Carcinoma in Situ - radiotherapy ; Cisplatin - administration & dosage ; Combined Modality Therapy ; Follicle Stimulating Hormone - metabolism ; Germany ; Germinoma - drug therapy ; Germinoma - metabolism ; Germinoma - pathology ; Germinoma - radiotherapy ; Humans ; Luteinizing Hormone - metabolism ; Male ; Neoplasms, Multiple Primary - drug therapy ; Neoplasms, Multiple Primary - metabolism ; Neoplasms, Multiple Primary - pathology ; Neoplasms, Multiple Primary - radiotherapy ; Predictive Value of Tests ; Remission Induction ; Risk Factors ; Testicular Neoplasms - drug therapy ; Testicular Neoplasms - metabolism ; Testicular Neoplasms - pathology ; Testicular Neoplasms - radiotherapy ; Testis - abnormalities ; Testis - metabolism ; Testis - pathology ; Testosterone - blood ; Treatment Outcome</subject><ispartof>World journal of urology, 1994-06, Vol.12 (3), p.131-135</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-b444e86e77cd754ffb14d4b0cae18770eb509442123c75c62d8f8eb8037ae4bd3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7951338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dieckmann, K P</creatorcontrib><creatorcontrib>Loy, V</creatorcontrib><title>Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor</title><title>World journal of urology</title><addtitle>World J Urol</addtitle><description>Contralateral biopsies from 1810 consecutive patients with testicular germ-cell tumor were examined immunohistologically by staining for placental alkaline phosphatase. Contralateral testicular intraepithelial neoplasia (TIN; carcinoma in situ) was found in 89 patients (4.9%; 95% confidence interval, 3.9%-5.9%). Testicular atrophy was present in 45.9% of patients with TIN and in 13.1% of those without TIN (P < 0.01). There was a history of cryptorchidism in 16.2% of patients with TIN versus only 8.5% of those without TIN (P < 0.05). Patients with contralateral TIN presented at an earlier age (30.8 versus 33.3 years). In all, 23 patients with contralateral TIN had no specific risk marker. In 14 patients with contralateral TIN who had received local radiotherapy of 18-20 Gy to the testis, rebiopsy revealed the disappearance of TIN in all cases. Serum testosterone levels were within or above the normal range in 7 of 13 patients examined after local radiotherapy. Of 9 patients with contralateral TIN who had received chemotherapy, 2 were shown to have persistent TIN at rebiopsy. We conclude that all patients with testicular germ-cell tumor should be offered a contralateral biopsy. Local radiotherapy of the testis is the treatment of choice in patients with contralateral TIN.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</subject><subject>Austria</subject><subject>Biomarkers, Tumor - metabolism</subject><subject>Biopsy</subject><subject>Carcinoma in Situ - drug therapy</subject><subject>Carcinoma in Situ - metabolism</subject><subject>Carcinoma in Situ - pathology</subject><subject>Carcinoma in Situ - radiotherapy</subject><subject>Cisplatin - administration & dosage</subject><subject>Combined Modality Therapy</subject><subject>Follicle Stimulating Hormone - metabolism</subject><subject>Germany</subject><subject>Germinoma - drug therapy</subject><subject>Germinoma - metabolism</subject><subject>Germinoma - pathology</subject><subject>Germinoma - radiotherapy</subject><subject>Humans</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Male</subject><subject>Neoplasms, Multiple Primary - drug therapy</subject><subject>Neoplasms, Multiple Primary - metabolism</subject><subject>Neoplasms, Multiple Primary - pathology</subject><subject>Neoplasms, Multiple Primary - radiotherapy</subject><subject>Predictive Value of Tests</subject><subject>Remission Induction</subject><subject>Risk Factors</subject><subject>Testicular Neoplasms - drug therapy</subject><subject>Testicular Neoplasms - metabolism</subject><subject>Testicular Neoplasms - pathology</subject><subject>Testicular Neoplasms - radiotherapy</subject><subject>Testis - abnormalities</subject><subject>Testis - metabolism</subject><subject>Testis - pathology</subject><subject>Testosterone - blood</subject><subject>Treatment Outcome</subject><issn>0724-4983</issn><issn>1433-8726</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkM1LAzEQxYMotVYv3oU9eRBW87VJ9qjFqlDxouclyc7WyH6ZZBH_e1Na1MsMzPvN4_EQOif4mmAsb-5WGJOSUlEeoDnhjOVKUnGI5lhSnvNSsWN0EsJHoqTAxQzNZFkQxtQctc-61xvooI_Z0GR26KPXrY6QZhYhRGenVvvMbe8wuvgOrUtSD8PY6uB0UrJRR5cMQvaV9P9fG_BdbqFNVlM3-FN01Og2wNl-L9Db6v51-ZivXx6elrfr3FJFY24456AESGlrWfCmMYTX3GCrgSgpMZgCl5xTQpmVhRW0Vo0CozCTGrip2QJd7nxHP3xOKU7VubCNoVPsKVRSyJIWgiTwagdaP4TgoalG7zrtvyuCq2211V-1Cb7Yu06mg_oX3XfJfgCUAnYP</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Dieckmann, K P</creator><creator>Loy, V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor</title><author>Dieckmann, K P ; Loy, V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-b444e86e77cd754ffb14d4b0cae18770eb509442123c75c62d8f8eb8037ae4bd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Antineoplastic Combined Chemotherapy Protocols - therapeutic use</topic><topic>Austria</topic><topic>Biomarkers, Tumor - metabolism</topic><topic>Biopsy</topic><topic>Carcinoma in Situ - drug therapy</topic><topic>Carcinoma in Situ - metabolism</topic><topic>Carcinoma in Situ - pathology</topic><topic>Carcinoma in Situ - radiotherapy</topic><topic>Cisplatin - administration & dosage</topic><topic>Combined Modality Therapy</topic><topic>Follicle Stimulating Hormone - metabolism</topic><topic>Germany</topic><topic>Germinoma - drug therapy</topic><topic>Germinoma - metabolism</topic><topic>Germinoma - pathology</topic><topic>Germinoma - radiotherapy</topic><topic>Humans</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Male</topic><topic>Neoplasms, Multiple Primary - drug therapy</topic><topic>Neoplasms, Multiple Primary - metabolism</topic><topic>Neoplasms, Multiple Primary - pathology</topic><topic>Neoplasms, Multiple Primary - radiotherapy</topic><topic>Predictive Value of Tests</topic><topic>Remission Induction</topic><topic>Risk Factors</topic><topic>Testicular Neoplasms - drug therapy</topic><topic>Testicular Neoplasms - metabolism</topic><topic>Testicular Neoplasms - pathology</topic><topic>Testicular Neoplasms - radiotherapy</topic><topic>Testis - abnormalities</topic><topic>Testis - metabolism</topic><topic>Testis - pathology</topic><topic>Testosterone - blood</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dieckmann, K P</creatorcontrib><creatorcontrib>Loy, V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of urology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dieckmann, K P</au><au>Loy, V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor</atitle><jtitle>World journal of urology</jtitle><addtitle>World J Urol</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>12</volume><issue>3</issue><spage>131</spage><epage>135</epage><pages>131-135</pages><issn>0724-4983</issn><eissn>1433-8726</eissn><abstract>Contralateral biopsies from 1810 consecutive patients with testicular germ-cell tumor were examined immunohistologically by staining for placental alkaline phosphatase. Contralateral testicular intraepithelial neoplasia (TIN; carcinoma in situ) was found in 89 patients (4.9%; 95% confidence interval, 3.9%-5.9%). Testicular atrophy was present in 45.9% of patients with TIN and in 13.1% of those without TIN (P < 0.01). There was a history of cryptorchidism in 16.2% of patients with TIN versus only 8.5% of those without TIN (P < 0.05). Patients with contralateral TIN presented at an earlier age (30.8 versus 33.3 years). In all, 23 patients with contralateral TIN had no specific risk marker. In 14 patients with contralateral TIN who had received local radiotherapy of 18-20 Gy to the testis, rebiopsy revealed the disappearance of TIN in all cases. Serum testosterone levels were within or above the normal range in 7 of 13 patients examined after local radiotherapy. Of 9 patients with contralateral TIN who had received chemotherapy, 2 were shown to have persistent TIN at rebiopsy. We conclude that all patients with testicular germ-cell tumor should be offered a contralateral biopsy. Local radiotherapy of the testis is the treatment of choice in patients with contralateral TIN.</abstract><cop>Germany</cop><pmid>7951338</pmid><doi>10.1007/BF00192269</doi><tpages>5</tpages></addata></record> |
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| subjects | Adult Age Factors Antineoplastic Combined Chemotherapy Protocols - therapeutic use Austria Biomarkers, Tumor - metabolism Biopsy Carcinoma in Situ - drug therapy Carcinoma in Situ - metabolism Carcinoma in Situ - pathology Carcinoma in Situ - radiotherapy Cisplatin - administration & dosage Combined Modality Therapy Follicle Stimulating Hormone - metabolism Germany Germinoma - drug therapy Germinoma - metabolism Germinoma - pathology Germinoma - radiotherapy Humans Luteinizing Hormone - metabolism Male Neoplasms, Multiple Primary - drug therapy Neoplasms, Multiple Primary - metabolism Neoplasms, Multiple Primary - pathology Neoplasms, Multiple Primary - radiotherapy Predictive Value of Tests Remission Induction Risk Factors Testicular Neoplasms - drug therapy Testicular Neoplasms - metabolism Testicular Neoplasms - pathology Testicular Neoplasms - radiotherapy Testis - abnormalities Testis - metabolism Testis - pathology Testosterone - blood Treatment Outcome |
| title | Management of contralateral testicular intraepithelial neoplasia in patients with testicular germ-cell tumor |
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