Myosin Catalytic Domain Flexibility in MgADP

Conventional EPR studies of muscle fibers labeled with a novel alpha-iodoketo spin label at Cys-707 of the myosin head revealed substantial internal domain reorganization on the addition of ADP to rigor fibers. The spin probes that are well-ordered in the rigor state become disordered and form two d...

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Veröffentlicht in:	Biochemistry (Easton) 1994-11, Vol.33 (47), p.14317-14323
Hauptverfasser:	Raucher, Drazen, Sar, Cecilia P, Hideg, Kalman, Fajer, Piotr G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine Diphosphate - pharmacology Adenosine Triphosphate - pharmacology Animals Binding Sites Cyclic N-Oxides Electron Spin Resonance Spectroscopy Myosins - chemistry Protein Conformation Rabbits Space life sciences Spin Labels
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