Determination of the Solution Structure of the Peptide Hormone Guanylin: Observation of a Novel Form of Topological Stereoisomerism

Guanylin is a 15 amino acid mammalian hormone containing two disulfide bonds. Guanylin shares sequence similarity with the bacterial heat-stable enterotoxin (STa) and is capable of binding to and stimulating the STa guanylyl cyclase receptor. Biologically active peptides have been prepared by two me...

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Veröffentlicht in:	Biochemistry (Easton) 1994-11, Vol.33 (46), p.13581-13592
Hauptverfasser:	Skelton, Nicholas J, Garcia, K. Christopher, Goeddel, David V, Quan, Clifford, Burnier, John P
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacterial Toxins - chemistry Computer Graphics Enterotoxins - chemistry Escherichia coli Escherichia coli Proteins Gastrointestinal Hormones Guanylate Cyclase - metabolism Magnetic Resonance Spectroscopy Molecular Sequence Data Natriuretic Peptides Peptide Fragments - chemistry Peptides - chemistry Protein Conformation Protein Precursors - chemistry Protein Precursors - genetics Protein Precursors - metabolism Receptors, Atrial Natriuretic Factor Receptors, Cell Surface - metabolism Recombinant Proteins Sequence Homology, Amino Acid Solutions Stereoisomerism
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