Selective antimitochondrial agents inhibit calmodulin

Certain cationic-lipophilic compounds are known to selectively accumulate in tumor mitochondria and inhibit energy production. Since these substances bear a structural resemblance to known inhibitors of calmodulin, we studied whether rhodamine-123 or a bis-4-aminoquinaldinium could antagonize the ac...

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Veröffentlicht in:	Biochemical and biophysical research communications 1986-03, Vol.135 (2), p.574-582
Hauptverfasser:	Bodden, William L., Palayoor, Sanjeewani T., Hai, William N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Applied sciences Calmodulin - antagonists & inhibitors Cell Division - drug effects Cell Line Dequalinium - pharmacology Exact sciences and technology Glioma Kinetics Mitochondria - drug effects Mitochondria - metabolism Other techniques and industries Phosphoric Diester Hydrolases - metabolism Quinolinium Compounds - pharmacology Rats Rhodamine 123 Rhodamines - pharmacology Structure-Activity Relationship
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