Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility

The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-ind...

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Veröffentlicht in:	Digestive diseases and sciences 1986-05, Vol.31 (5), p.524-529
Hauptverfasser:	ALPHIN, R. S, PROAKIS, A. G, LEONARD, C. A, SMITH, W. L, DANNENBURG, W. N, KINNIER, W. J, JOHNSON, D. N, SANCILIO, L. F, WARD, J. W
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic agents Benzamides - metabolism Benzamides - pharmacology Biological and medical sciences Chemotherapy Cisplatin - antagonists & inhibitors Dogs Dose-Response Relationship, Drug Female Gastrointestinal Motility - drug effects Male Medical sciences Metoclopramide - metabolism Metoclopramide - pharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Sulpiride - metabolism Sulpiride - pharmacology Vomiting - chemically induced Vomiting - drug therapy Vomiting - physiopathology
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