Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility
The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-ind...
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| Veröffentlicht in: | Digestive diseases and sciences 1986-05, Vol.31 (5), p.524-529 |
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| container_title | Digestive diseases and sciences |
| container_volume | 31 |
| creator | ALPHIN, R. S PROAKIS, A. G LEONARD, C. A SMITH, W. L DANNENBURG, W. N KINNIER, W. J JOHNSON, D. N SANCILIO, L. F WARD, J. W |
| description | The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis. |
| doi_str_mv | 10.1007/bf01320319 |
| format | Article |
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S ; PROAKIS, A. G ; LEONARD, C. A ; SMITH, W. L ; DANNENBURG, W. N ; KINNIER, W. J ; JOHNSON, D. N ; SANCILIO, L. F ; WARD, J. W</creator><creatorcontrib>ALPHIN, R. S ; PROAKIS, A. G ; LEONARD, C. A ; SMITH, W. L ; DANNENBURG, W. N ; KINNIER, W. J ; JOHNSON, D. N ; SANCILIO, L. F ; WARD, J. W</creatorcontrib><description>The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis.</description><identifier>ISSN: 0163-2116</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/bf01320319</identifier><identifier>PMID: 3698769</identifier><identifier>CODEN: DDSCDJ</identifier><language>eng</language><publisher>Heidelberg: Springer</publisher><subject>Animals ; Antineoplastic agents ; Benzamides - metabolism ; Benzamides - pharmacology ; Biological and medical sciences ; Chemotherapy ; Cisplatin - antagonists & inhibitors ; Dogs ; Dose-Response Relationship, Drug ; Female ; Gastrointestinal Motility - drug effects ; Male ; Medical sciences ; Metoclopramide - metabolism ; Metoclopramide - pharmacology ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; Receptors, Dopamine - drug effects ; Sulpiride - metabolism ; Sulpiride - pharmacology ; Vomiting - chemically induced ; Vomiting - drug therapy ; Vomiting - physiopathology</subject><ispartof>Digestive diseases and sciences, 1986-05, Vol.31 (5), p.524-529</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c377t-ae3dde3b81c9b841bea919d19d89b0e4d4be0b5445b7a5872c7b851a0fa6e8523</citedby><cites>FETCH-LOGICAL-c377t-ae3dde3b81c9b841bea919d19d89b0e4d4be0b5445b7a5872c7b851a0fa6e8523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7859154$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3698769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>ALPHIN, R. S</creatorcontrib><creatorcontrib>PROAKIS, A. G</creatorcontrib><creatorcontrib>LEONARD, C. A</creatorcontrib><creatorcontrib>SMITH, W. L</creatorcontrib><creatorcontrib>DANNENBURG, W. N</creatorcontrib><creatorcontrib>KINNIER, W. J</creatorcontrib><creatorcontrib>JOHNSON, D. N</creatorcontrib><creatorcontrib>SANCILIO, L. F</creatorcontrib><creatorcontrib>WARD, J. W</creatorcontrib><title>Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Benzamides - metabolism</subject><subject>Benzamides - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Cisplatin - antagonists & inhibitors</subject><subject>Dogs</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Gastrointestinal Motility - drug effects</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metoclopramide - metabolism</subject><subject>Metoclopramide - pharmacology</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Dopamine - drug effects</subject><subject>Sulpiride - metabolism</subject><subject>Sulpiride - pharmacology</subject><subject>Vomiting - chemically induced</subject><subject>Vomiting - drug therapy</subject><subject>Vomiting - physiopathology</subject><issn>0163-2116</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1r3DAQxUVoSLdJLrkXdCg9FNxKK8uSjknIRyGQS3o2I2m8q2JLW0s-bP76askmMDDzmN88mEfIFWc_OWPqlx0YF2smuDkhKy6VaNay05_IivGuzpx3n8mXnP8yxozi3Rk5E53RqjMrEq9jgU2KIU80DdSFvBuhhNiE6BeHnuKEOWRq93TCktyYdjNMwSOF6KmH16oPqmzntGy2FOMWoqtHsRz8NpDLHBydUgljKPsLcjrAmPHy2M_Jn_u7l9vH5un54fft9VPjhFKlARTeo7CaO2N1yy2C4cbX0sYybH1rkVnZttIqkFqtnbJacmADdKjlWpyT72--uzn9WzCXfgrZ4ThCxLTkXnXKMKnaCv54A92ccp5x6Os_E8z7nrP-EG5_c_8eboW_Hl0XO6H_QI9p1v234x6yg3GYaxQhf2BKS8NlK_4D7w-DnQ</recordid><startdate>19860501</startdate><enddate>19860501</enddate><creator>ALPHIN, R. S</creator><creator>PROAKIS, A. G</creator><creator>LEONARD, C. A</creator><creator>SMITH, W. L</creator><creator>DANNENBURG, W. N</creator><creator>KINNIER, W. J</creator><creator>JOHNSON, D. N</creator><creator>SANCILIO, L. F</creator><creator>WARD, J. W</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860501</creationdate><title>Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility</title><author>ALPHIN, R. S ; PROAKIS, A. G ; LEONARD, C. A ; SMITH, W. L ; DANNENBURG, W. N ; KINNIER, W. J ; JOHNSON, D. N ; SANCILIO, L. F ; WARD, J. 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Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Dopamine - drug effects</topic><topic>Sulpiride - metabolism</topic><topic>Sulpiride - pharmacology</topic><topic>Vomiting - chemically induced</topic><topic>Vomiting - drug therapy</topic><topic>Vomiting - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>ALPHIN, R. S</creatorcontrib><creatorcontrib>PROAKIS, A. G</creatorcontrib><creatorcontrib>LEONARD, C. A</creatorcontrib><creatorcontrib>SMITH, W. L</creatorcontrib><creatorcontrib>DANNENBURG, W. N</creatorcontrib><creatorcontrib>KINNIER, W. J</creatorcontrib><creatorcontrib>JOHNSON, D. N</creatorcontrib><creatorcontrib>SANCILIO, L. F</creatorcontrib><creatorcontrib>WARD, J. 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W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>1986-05-01</date><risdate>1986</risdate><volume>31</volume><issue>5</issue><spage>524</spage><epage>529</epage><pages>524-529</pages><issn>0163-2116</issn><eissn>1573-2568</eissn><coden>DDSCDJ</coden><abstract>The antiemetic activity, gastric motor activity, and dopamine receptor effects of metoclopramide, dazopride, and sulpiride were assessed to establish if enhancement of gastric motility or antagonism of central dopamine receptors is the predominant action for drug-induced suppression of cisplatin-induced emesis. Emesis produced in dogs by cisplatin is antagonized by metoclopramide and dazopride. The antiemetic actions of metoclopramide and dazopride are associated with their ability to enhance gastric motor activity. Dazopride, unlike metoclopramide, has minimal dopamine receptor antagonist properties. Sulpiride is a potent dopamine receptor antagonist; however, it had no effect on the stomach and was ineffective in suppressing cisplatin-induced emesis.</abstract><cop>Heidelberg</cop><pub>Springer</pub><pmid>3698769</pmid><doi>10.1007/bf01320319</doi><tpages>6</tpages></addata></record> |
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| ispartof | Digestive diseases and sciences, 1986-05, Vol.31 (5), p.524-529 |
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| language | eng |
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| source | MEDLINE; Springer Online Journals Complete |
| subjects | Animals Antineoplastic agents Benzamides - metabolism Benzamides - pharmacology Biological and medical sciences Chemotherapy Cisplatin - antagonists & inhibitors Dogs Dose-Response Relationship, Drug Female Gastrointestinal Motility - drug effects Male Medical sciences Metoclopramide - metabolism Metoclopramide - pharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Receptors, Dopamine - drug effects Sulpiride - metabolism Sulpiride - pharmacology Vomiting - chemically induced Vomiting - drug therapy Vomiting - physiopathology |
| title | Antagonism of cisplatin-induced emesis by metoclopramide and dazopride through enhancement of gastric motility |
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