Urinary Excretion Levels of Hydroxylysine Glycosides in Osteoporotic Patients
The urinary excretion levels of hydroxylysine glycosides [Hyl-Gs ; O-β-D-Galactopyranosylhydroxylysine (GH) and 2-O-α-D-glucopyranosyl-O-β-D-galactopyranosylhydroxylysine (GGH)], provide a new index of collagen metabolism. The determination of urinary hydroxylysine glycoside excretion levels was app...
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| Veröffentlicht in: | Biological & pharmaceutical bulletin 1994/06/15, Vol.17(6), pp.836-839 |
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| creator | YOSHIHARA, Kazuhiro MOCHIDOME, Naritoshi HARA, Takashi OSADA, Satoru TAKAYAMA, Akinori NAGATA, Minoru |
| description | The urinary excretion levels of hydroxylysine glycosides [Hyl-Gs ; O-β-D-Galactopyranosylhydroxylysine (GH) and 2-O-α-D-glucopyranosyl-O-β-D-galactopyranosylhydroxylysine (GGH)], provide a new index of collagen metabolism. The determination of urinary hydroxylysine glycoside excretion levels was applied to 20 osteoporotic patients and 208 healthy control subjects (69 females and 139 males) in order to evaluate the conditions of bone collagen metabolism. Urinary Hyl-Gs were analyzed by the method of pre-column fluorescent derivatized HPLC. Compared to the age and sex-adjusted control, the urinary excretion levels of hydroxylysine glycosides, especially GH, in osteoporotic patients were significantly higher than in the age and sex-adjusted control, and the urinary GGH/GH ratio was lower. Sixteen of the 20 patients whose Hyl-Gs levels we followed exhibited significantly lower values after 200 d compared to the initial levels. These results suggest that clinical therapeutics affected the bone resorption and, therefore, demonstrated the usefulness of determining urinary excretion levels of Hyl-Gs for evaluating the conditions of bone metabolism. |
| doi_str_mv | 10.1248/bpb.17.836 |
| format | Article |
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The determination of urinary hydroxylysine glycoside excretion levels was applied to 20 osteoporotic patients and 208 healthy control subjects (69 females and 139 males) in order to evaluate the conditions of bone collagen metabolism. Urinary Hyl-Gs were analyzed by the method of pre-column fluorescent derivatized HPLC. Compared to the age and sex-adjusted control, the urinary excretion levels of hydroxylysine glycosides, especially GH, in osteoporotic patients were significantly higher than in the age and sex-adjusted control, and the urinary GGH/GH ratio was lower. Sixteen of the 20 patients whose Hyl-Gs levels we followed exhibited significantly lower values after 200 d compared to the initial levels. These results suggest that clinical therapeutics affected the bone resorption and, therefore, demonstrated the usefulness of determining urinary excretion levels of Hyl-Gs for evaluating the conditions of bone metabolism.</description><identifier>ISSN: 0918-6158</identifier><identifier>EISSN: 1347-5215</identifier><identifier>DOI: 10.1248/bpb.17.836</identifier><identifier>PMID: 7951149</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Biological and medical sciences ; biomedical marker ; bone resorption ; Bone Resorption - drug therapy ; Bone Resorption - urine ; Chromatography, High Pressure Liquid ; Collagen - metabolism ; Female ; Humans ; Hydroxylysine - analogs & derivatives ; Hydroxylysine - therapeutic use ; Hydroxylysine - urine ; hydroxylysine glycoside ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Osteoarticular system. Muscles ; osteoporosis ; Osteoporosis - drug therapy ; Osteoporosis - urine ; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques ; urinary excretion level</subject><ispartof>Biological and Pharmaceutical Bulletin, 1994/06/15, Vol.17(6), pp.836-839</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1995 INIST-CNRS</rights><rights>Copyright Japan Science and Technology Agency 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c633t-61c5eee46bb1ccde57bbc439c1377c653689799c8e54365c2de9c5c969f367583</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1881,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3341699$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7951149$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>YOSHIHARA, Kazuhiro</creatorcontrib><creatorcontrib>MOCHIDOME, Naritoshi</creatorcontrib><creatorcontrib>HARA, Takashi</creatorcontrib><creatorcontrib>OSADA, Satoru</creatorcontrib><creatorcontrib>TAKAYAMA, Akinori</creatorcontrib><creatorcontrib>NAGATA, Minoru</creatorcontrib><title>Urinary Excretion Levels of Hydroxylysine Glycosides in Osteoporotic Patients</title><title>Biological & pharmaceutical bulletin</title><addtitle>Biol Pharm Bull</addtitle><description>The urinary excretion levels of hydroxylysine glycosides [Hyl-Gs ; O-β-D-Galactopyranosylhydroxylysine (GH) and 2-O-α-D-glucopyranosyl-O-β-D-galactopyranosylhydroxylysine (GGH)], provide a new index of collagen metabolism. The determination of urinary hydroxylysine glycoside excretion levels was applied to 20 osteoporotic patients and 208 healthy control subjects (69 females and 139 males) in order to evaluate the conditions of bone collagen metabolism. Urinary Hyl-Gs were analyzed by the method of pre-column fluorescent derivatized HPLC. Compared to the age and sex-adjusted control, the urinary excretion levels of hydroxylysine glycosides, especially GH, in osteoporotic patients were significantly higher than in the age and sex-adjusted control, and the urinary GGH/GH ratio was lower. Sixteen of the 20 patients whose Hyl-Gs levels we followed exhibited significantly lower values after 200 d compared to the initial levels. These results suggest that clinical therapeutics affected the bone resorption and, therefore, demonstrated the usefulness of determining urinary excretion levels of Hyl-Gs for evaluating the conditions of bone metabolism.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>biomedical marker</subject><subject>bone resorption</subject><subject>Bone Resorption - drug therapy</subject><subject>Bone Resorption - urine</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Collagen - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Hydroxylysine - analogs & derivatives</subject><subject>Hydroxylysine - therapeutic use</subject><subject>Hydroxylysine - urine</subject><subject>hydroxylysine glycoside</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Osteoarticular system. Muscles</subject><subject>osteoporosis</subject><subject>Osteoporosis - drug therapy</subject><subject>Osteoporosis - urine</subject><subject>Pathology. Cytology. Biochemistry. Spectrometry. 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Muscles</topic><topic>osteoporosis</topic><topic>Osteoporosis - drug therapy</topic><topic>Osteoporosis - urine</topic><topic>Pathology. Cytology. Biochemistry. Spectrometry. 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The determination of urinary hydroxylysine glycoside excretion levels was applied to 20 osteoporotic patients and 208 healthy control subjects (69 females and 139 males) in order to evaluate the conditions of bone collagen metabolism. Urinary Hyl-Gs were analyzed by the method of pre-column fluorescent derivatized HPLC. Compared to the age and sex-adjusted control, the urinary excretion levels of hydroxylysine glycosides, especially GH, in osteoporotic patients were significantly higher than in the age and sex-adjusted control, and the urinary GGH/GH ratio was lower. Sixteen of the 20 patients whose Hyl-Gs levels we followed exhibited significantly lower values after 200 d compared to the initial levels. 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| subjects | Adult Aged Aged, 80 and over Biological and medical sciences biomedical marker bone resorption Bone Resorption - drug therapy Bone Resorption - urine Chromatography, High Pressure Liquid Collagen - metabolism Female Humans Hydroxylysine - analogs & derivatives Hydroxylysine - therapeutic use Hydroxylysine - urine hydroxylysine glycoside Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Osteoarticular system. Muscles osteoporosis Osteoporosis - drug therapy Osteoporosis - urine Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques urinary excretion level |
| title | Urinary Excretion Levels of Hydroxylysine Glycosides in Osteoporotic Patients |
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