Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging
Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects of cognition and emotion. Most efforts to identify its underlying neural substrates have focused on a strategy that relates a single symptom to a single brain region. An alternative hypothesis, that...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1994-10, Vol.266 (5183), p.294-298 |
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| creator | Andreasen, Nancy C. Arndt, Stephan Swayze, Victor Cizadlo, Ted Flaum, Michael O'Leary, Daniel Ehrhardt, James C. William T. C. Yuh |
| description | Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects of cognition and emotion. Most efforts to identify its underlying neural substrates have focused on a strategy that relates a single symptom to a single brain region. An alternative hypothesis, that the variety of symptoms could be explained by a lesion in midline neural circuits mediating attention and information processing, is explored. Magnetic resonance images from patients and controls were transformed with a "bounding box" to produce an "average schizophrenic brain" and an "average normal brain." After image subtraction of the two averages, the areas of difference were displayed as an effect size map. Specific regional abnormalities were observed in the thalamus and adjacent white matter. An abnormality in the thalamus and related circuitry explains the diverse symptoms of schizophrenia parsimoniously because they could all result from a defect in filtering or gating sensory input, which is one of the primary functions of the thalamus in the human brain. |
| doi_str_mv | 10.1126/science.7939669 |
| format | Article |
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Specific regional abnormalities were observed in the thalamus and adjacent white matter. 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C. Yuh</creatorcontrib><title>Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Schizophrenia is a complex illness characterized by multiple types of symptoms involving many aspects of cognition and emotion. Most efforts to identify its underlying neural substrates have focused on a strategy that relates a single symptom to a single brain region. An alternative hypothesis, that the variety of symptoms could be explained by a lesion in midline neural circuits mediating attention and information processing, is explored. Magnetic resonance images from patients and controls were transformed with a "bounding box" to produce an "average schizophrenic brain" and an "average normal brain." After image subtraction of the two averages, the areas of difference were displayed as an effect size map. 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Psychiatry</subject><subject>Psychopathology. 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| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1994-10, Vol.266 (5183), p.294-298 |
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| language | eng |
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| source | MEDLINE; JSTOR Archive Collection A-Z Listing; American Association for the Advancement of Science |
| subjects | Abnormalities Adult and adolescent clinical studies Biological and medical sciences Brain - pathology Diseases Disorders Female Humans Image analysis Image Processing, Computer-Assisted Magnetic resonance imaging Magnetic Resonance Imaging - methods Male Medical sciences Physiological aspects Pixels Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Schizophrenia Schizophrenia - pathology Software Subtraction Technique Thalamus Thalamus - pathology Volunteerism White matter |
| title | Thalamic Abnormalities in Schizophrenia Visualized Through Magnetic Resonance Image Averaging |
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