Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog
Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA fr...
Gespeichert in:
| Veröffentlicht in: | Biochemical and biophysical research communications 1994-09, Vol.203 (3), p.1663-1667 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1667 |
|---|---|
| container_issue | 3 |
| container_start_page | 1663 |
| container_title | Biochemical and biophysical research communications |
| container_volume | 203 |
| creator | Shastry, B.S. Reddy, V.N. |
| description | Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease. |
| doi_str_mv | 10.1006/bbrc.1994.2377 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76788918</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0006291X84723771</els_id><sourcerecordid>76788918</sourcerecordid><originalsourceid>FETCH-LOGICAL-c358t-2c04492cd9ee683b77dea96b0a8f726460c747449454147f71d48617203648613</originalsourceid><addsrcrecordid>eNp1kM1rGzEQxUVpcB2n1x4KBZ1yW0fSaqXVsTgfLqT04BgCOQitdtZWWa9cSRtI__posemtpxnmvRnp_RD6QsmSEiJumibYJVWKL1kp5Qc0p0SRglHCP6I5yY6CKfr8CV3G-JsQSrlQMzSTilclreboZZPG1kHEfsArP-xgcMn0eA0B2tyFN7wyuRibsBla_NPZ4I_7tDf9wRnsO5z2kKeDM2kMgDd2P5jxLwR863dX6KIzfYTP57pA2_u7p9W6ePz18GP1_bGwZVWnglnCuWK2VQCiLhspWzBKNMTUnWSCC2Ill9nCK0657CRteS2oZKQUU1Mu0PXp7jH4PyPEpA8uWuh7M4Afo5ZC1rWidTYuT8YcIsYAnT4Gd8ghNSV6oqknmnqiqSeaeeHb-fLYHKD9Zz_jy_rXk94Zr80uuKi3G1UxWbLpW_VJhJz91UHQ0ToYbAYbwCbdeve_d98BH1iKuA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76788918</pqid></control><display><type>article</type><title>Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Shastry, B.S. ; Reddy, V.N.</creator><creatorcontrib>Shastry, B.S. ; Reddy, V.N.</creatorcontrib><description>Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease.</description><identifier>ISSN: 0006-291X</identifier><identifier>EISSN: 1090-2104</identifier><identifier>DOI: 10.1006/bbrc.1994.2377</identifier><identifier>PMID: 7945315</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ADN ; Animals ; Aniridia - genetics ; Base Sequence ; Cataract - genetics ; Cataract - veterinary ; CATARACTE ; CATARATAS ; CHIEN ; Chromosome Mapping ; Chromosomes, Human, Pair 11 ; DNA - blood ; DNA - genetics ; DNA - isolation & purification ; DNA Primers ; Dog Diseases - genetics ; Dogs ; Electrophoresis, Agar Gel ; Humans ; LEUCOCITOS ; LEUCOCYTE ; Leukocytes - metabolism ; LOCI ; LOCUS ; Microphthalmos - genetics ; Microphthalmos - veterinary ; Molecular Sequence Data ; MUTACION ; MUTATION ; PERRO ; Polymerase Chain Reaction ; Polymorphism, Genetic ; TRASTORNOS GENETICOS ; TROUBLE GENETIQUE</subject><ispartof>Biochemical and biophysical research communications, 1994-09, Vol.203 (3), p.1663-1667</ispartof><rights>1994 Academic Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c358t-2c04492cd9ee683b77dea96b0a8f726460c747449454147f71d48617203648613</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1006/bbrc.1994.2377$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3549,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7945315$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shastry, B.S.</creatorcontrib><creatorcontrib>Reddy, V.N.</creatorcontrib><title>Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog</title><title>Biochemical and biophysical research communications</title><addtitle>Biochem Biophys Res Commun</addtitle><description>Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease.</description><subject>ADN</subject><subject>Animals</subject><subject>Aniridia - genetics</subject><subject>Base Sequence</subject><subject>Cataract - genetics</subject><subject>Cataract - veterinary</subject><subject>CATARACTE</subject><subject>CATARATAS</subject><subject>CHIEN</subject><subject>Chromosome Mapping</subject><subject>Chromosomes, Human, Pair 11</subject><subject>DNA - blood</subject><subject>DNA - genetics</subject><subject>DNA - isolation & purification</subject><subject>DNA Primers</subject><subject>Dog Diseases - genetics</subject><subject>Dogs</subject><subject>Electrophoresis, Agar Gel</subject><subject>Humans</subject><subject>LEUCOCITOS</subject><subject>LEUCOCYTE</subject><subject>Leukocytes - metabolism</subject><subject>LOCI</subject><subject>LOCUS</subject><subject>Microphthalmos - genetics</subject><subject>Microphthalmos - veterinary</subject><subject>Molecular Sequence Data</subject><subject>MUTACION</subject><subject>MUTATION</subject><subject>PERRO</subject><subject>Polymerase Chain Reaction</subject><subject>Polymorphism, Genetic</subject><subject>TRASTORNOS GENETICOS</subject><subject>TROUBLE GENETIQUE</subject><issn>0006-291X</issn><issn>1090-2104</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kM1rGzEQxUVpcB2n1x4KBZ1yW0fSaqXVsTgfLqT04BgCOQitdtZWWa9cSRtI__posemtpxnmvRnp_RD6QsmSEiJumibYJVWKL1kp5Qc0p0SRglHCP6I5yY6CKfr8CV3G-JsQSrlQMzSTilclreboZZPG1kHEfsArP-xgcMn0eA0B2tyFN7wyuRibsBla_NPZ4I_7tDf9wRnsO5z2kKeDM2kMgDd2P5jxLwR863dX6KIzfYTP57pA2_u7p9W6ePz18GP1_bGwZVWnglnCuWK2VQCiLhspWzBKNMTUnWSCC2Ill9nCK0657CRteS2oZKQUU1Mu0PXp7jH4PyPEpA8uWuh7M4Afo5ZC1rWidTYuT8YcIsYAnT4Gd8ghNSV6oqknmnqiqSeaeeHb-fLYHKD9Zz_jy_rXk94Zr80uuKi3G1UxWbLpW_VJhJz91UHQ0ToYbAYbwCbdeve_d98BH1iKuA</recordid><startdate>19940930</startdate><enddate>19940930</enddate><creator>Shastry, B.S.</creator><creator>Reddy, V.N.</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940930</creationdate><title>Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog</title><author>Shastry, B.S. ; Reddy, V.N.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c358t-2c04492cd9ee683b77dea96b0a8f726460c747449454147f71d48617203648613</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ADN</topic><topic>Animals</topic><topic>Aniridia - genetics</topic><topic>Base Sequence</topic><topic>Cataract - genetics</topic><topic>Cataract - veterinary</topic><topic>CATARACTE</topic><topic>CATARATAS</topic><topic>CHIEN</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Human, Pair 11</topic><topic>DNA - blood</topic><topic>DNA - genetics</topic><topic>DNA - isolation & purification</topic><topic>DNA Primers</topic><topic>Dog Diseases - genetics</topic><topic>Dogs</topic><topic>Electrophoresis, Agar Gel</topic><topic>Humans</topic><topic>LEUCOCITOS</topic><topic>LEUCOCYTE</topic><topic>Leukocytes - metabolism</topic><topic>LOCI</topic><topic>LOCUS</topic><topic>Microphthalmos - genetics</topic><topic>Microphthalmos - veterinary</topic><topic>Molecular Sequence Data</topic><topic>MUTACION</topic><topic>MUTATION</topic><topic>PERRO</topic><topic>Polymerase Chain Reaction</topic><topic>Polymorphism, Genetic</topic><topic>TRASTORNOS GENETICOS</topic><topic>TROUBLE GENETIQUE</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shastry, B.S.</creatorcontrib><creatorcontrib>Reddy, V.N.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biochemical and biophysical research communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shastry, B.S.</au><au>Reddy, V.N.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog</atitle><jtitle>Biochemical and biophysical research communications</jtitle><addtitle>Biochem Biophys Res Commun</addtitle><date>1994-09-30</date><risdate>1994</risdate><volume>203</volume><issue>3</issue><spage>1663</spage><epage>1667</epage><pages>1663-1667</pages><issn>0006-291X</issn><eissn>1090-2104</eissn><abstract>Hereditary cataract in dogs occurs as an autosomal recessive trait. The opacity is primarily in the lens nucleus and posterior cortex. The affected animals also have other ocular abnormalities such as microphthalmia. To understand the genetic basis of this disorder, we have analyzed leukocyte DNA from affected and normal dogs for possible mutations in the homeobox containing gene and myotonic dystrophy locus. The results show that there are no signs of microdeletion, insertion, point mutation and rearrangements in these loci. Although these observations cannot completely rule out the possibility of point mutations, they suggest that the above loci are unlikely to be associated with the disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7945315</pmid><doi>10.1006/bbrc.1994.2377</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0006-291X |
| ispartof | Biochemical and biophysical research communications, 1994-09, Vol.203 (3), p.1663-1667 |
| issn | 0006-291X 1090-2104 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76788918 |
| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ADN Animals Aniridia - genetics Base Sequence Cataract - genetics Cataract - veterinary CATARACTE CATARATAS CHIEN Chromosome Mapping Chromosomes, Human, Pair 11 DNA - blood DNA - genetics DNA - isolation & purification DNA Primers Dog Diseases - genetics Dogs Electrophoresis, Agar Gel Humans LEUCOCITOS LEUCOCYTE Leukocytes - metabolism LOCI LOCUS Microphthalmos - genetics Microphthalmos - veterinary Molecular Sequence Data MUTACION MUTATION PERRO Polymerase Chain Reaction Polymorphism, Genetic TRASTORNOS GENETICOS TROUBLE GENETIQUE |
| title | Studies on Congenital Hereditary Cataract and Microphthalmia of the Miniature Schnauzer Dog |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T20%3A11%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Studies%20on%20Congenital%20Hereditary%20Cataract%20and%20Microphthalmia%20of%20the%20Miniature%20Schnauzer%20Dog&rft.jtitle=Biochemical%20and%20biophysical%20research%20communications&rft.au=Shastry,%20B.S.&rft.date=1994-09-30&rft.volume=203&rft.issue=3&rft.spage=1663&rft.epage=1667&rft.pages=1663-1667&rft.issn=0006-291X&rft.eissn=1090-2104&rft_id=info:doi/10.1006/bbrc.1994.2377&rft_dat=%3Cproquest_cross%3E76788918%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76788918&rft_id=info:pmid/7945315&rft_els_id=S0006291X84723771&rfr_iscdi=true |