c-Fos: A Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling
Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression...
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| Veröffentlicht in: | Science (American Association for the Advancement of Science) 1994-10, Vol.266 (5184), p.443-448 |
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| creator | Grigoriadis, Agamemnon E. Wang, Zhao-Qi Cecchini, Marco G. Hofstetter, Willy Felix, Rolf Fleisch, Herbert A. Wagner, Erwin F. |
| description | Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases. |
| doi_str_mv | 10.1126/science.7939685 |
| format | Article |
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Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.</description><identifier>ISSN: 0036-8075</identifier><identifier>EISSN: 1095-9203</identifier><identifier>DOI: 10.1126/science.7939685</identifier><identifier>PMID: 7939685</identifier><identifier>CODEN: SCIEAS</identifier><language>eng</language><publisher>Washington, DC: American Society for the Advancement of Science</publisher><subject>Animals ; Biological and medical sciences ; Bone marrow ; Bone Marrow Transplantation ; Bone Remodeling - physiology ; Bone resorption ; Bones ; Capsules ; Cell Differentiation ; Cells, Cultured ; Fundamental and applied biological sciences. Psychology ; Genes, fos ; Hematopoietic Stem Cell Transplantation ; Hematopoietic stem cells ; Hematopoietic Stem Cells - cytology ; Macrophages ; Macrophages - cytology ; Mice ; Mice, Mutant Strains ; Osteoclasts ; Osteoclasts - cytology ; Osteogenesis ; Osteopetrosis ; Osteopetrosis - metabolism ; Osteopetrosis - pathology ; Progenitor cells ; Proto-Oncogene Proteins c-fos - genetics ; Proto-Oncogene Proteins c-fos - physiology ; Proto-oncogenes ; Skeleton and joints ; Space life sciences ; Spleen cells ; Stromal cells ; Vertebrates: osteoarticular system, musculoskeletal system</subject><ispartof>Science (American Association for the Advancement of Science), 1994-10, Vol.266 (5184), p.443-448</ispartof><rights>Copyright 1994 American Association for the Advancement of Science</rights><rights>1995 INIST-CNRS</rights><rights>COPYRIGHT 1994 American Association for the Advancement of Science</rights><rights>COPYRIGHT 1994 American Association for the Advancement of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c759t-7ee2e116b8760651d522401dcb01fd65f96ab13c6bffb709dd0f6b971d2dfe103</citedby><cites>FETCH-LOGICAL-c759t-7ee2e116b8760651d522401dcb01fd65f96ab13c6bffb709dd0f6b971d2dfe103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/2885332$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/2885332$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>314,776,780,799,2871,2872,27901,27902,57992,58225</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3314631$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7939685$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Grigoriadis, Agamemnon E.</creatorcontrib><creatorcontrib>Wang, Zhao-Qi</creatorcontrib><creatorcontrib>Cecchini, Marco G.</creatorcontrib><creatorcontrib>Hofstetter, Willy</creatorcontrib><creatorcontrib>Felix, Rolf</creatorcontrib><creatorcontrib>Fleisch, Herbert A.</creatorcontrib><creatorcontrib>Wagner, Erwin F.</creatorcontrib><title>c-Fos: A Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling</title><title>Science (American Association for the Advancement of Science)</title><addtitle>Science</addtitle><description>Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Bone marrow</subject><subject>Bone Marrow Transplantation</subject><subject>Bone Remodeling - physiology</subject><subject>Bone resorption</subject><subject>Bones</subject><subject>Capsules</subject><subject>Cell Differentiation</subject><subject>Cells, Cultured</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genes, fos</subject><subject>Hematopoietic Stem Cell Transplantation</subject><subject>Hematopoietic stem cells</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Macrophages</subject><subject>Macrophages - cytology</subject><subject>Mice</subject><subject>Mice, Mutant Strains</subject><subject>Osteoclasts</subject><subject>Osteoclasts - cytology</subject><subject>Osteogenesis</subject><subject>Osteopetrosis</subject><subject>Osteopetrosis - metabolism</subject><subject>Osteopetrosis - pathology</subject><subject>Progenitor cells</subject><subject>Proto-Oncogene Proteins c-fos - genetics</subject><subject>Proto-Oncogene Proteins c-fos - physiology</subject><subject>Proto-oncogenes</subject><subject>Skeleton and joints</subject><subject>Space life sciences</subject><subject>Spleen cells</subject><subject>Stromal cells</subject><subject>Vertebrates: osteoarticular system, musculoskeletal system</subject><issn>0036-8075</issn><issn>1095-9203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0s-LEzEUB_AgylpXz14U5iDiYWc3mXSSmb11q1sXqwV_gaeQSV7GLJmkTqbg_vdm7VApFCw5PMj75EF4X4SeE3xOSMEuorLgFZzzmtasKh-gCcF1mdcFpg_RBGPK8grz8jF6EuMtxqlX0xN0MvIJ-qHy6xAvs1n2Ae6yz9BunBxCnwWTreIAQTkZh_yjVH1Y_5QtZEvr4b6-hQH6zno52OAz6XV2FTykCV3Q4Kxvn6JHRroIz8Z6ir5dv_s6f58vV4ub-WyZK17WQ84BCiCENRVnmJVEl0UxxUSrBhOjWWlqJhtCFWuMaTiutcaGNTUnutAGCKan6PV27roPvzYQB9HZqMA56SFsouCMV9WUsv9CwljFCOcJnm1hKx0I600Yeqla8NBLlz5pbLqekbLGDP_l-QGejobOqkP-zZ5PZIDfQys3MYqbL5-OpqvvR9OrxbG0Wiz36NkhqoJz0IJIi5yv9vjFlqe4xNiDEevedrK_EwSL-7yKMa9iDGB68XJcyqbpQO_8v_6rsS-jks700isbd4xSMmWUJPZiy25jSu-uXVRpBC3oH47q-EE</recordid><startdate>19941021</startdate><enddate>19941021</enddate><creator>Grigoriadis, Agamemnon E.</creator><creator>Wang, Zhao-Qi</creator><creator>Cecchini, Marco G.</creator><creator>Hofstetter, Willy</creator><creator>Felix, Rolf</creator><creator>Fleisch, Herbert A.</creator><creator>Wagner, Erwin F.</creator><general>American Society for the Advancement of Science</general><general>American Association for the Advancement of Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>8GL</scope><scope>IBG</scope><scope>IOV</scope><scope>ISN</scope><scope>7QP</scope><scope>7TO</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19941021</creationdate><title>c-Fos: A Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling</title><author>Grigoriadis, Agamemnon E. ; Wang, Zhao-Qi ; Cecchini, Marco G. ; Hofstetter, Willy ; Felix, Rolf ; Fleisch, Herbert A. ; Wagner, Erwin F.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c759t-7ee2e116b8760651d522401dcb01fd65f96ab13c6bffb709dd0f6b971d2dfe103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Bone marrow</topic><topic>Bone Marrow Transplantation</topic><topic>Bone Remodeling - physiology</topic><topic>Bone resorption</topic><topic>Bones</topic><topic>Capsules</topic><topic>Cell Differentiation</topic><topic>Cells, Cultured</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genes, fos</topic><topic>Hematopoietic Stem Cell Transplantation</topic><topic>Hematopoietic stem cells</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Macrophages</topic><topic>Macrophages - cytology</topic><topic>Mice</topic><topic>Mice, Mutant Strains</topic><topic>Osteoclasts</topic><topic>Osteoclasts - cytology</topic><topic>Osteogenesis</topic><topic>Osteopetrosis</topic><topic>Osteopetrosis - metabolism</topic><topic>Osteopetrosis - pathology</topic><topic>Progenitor cells</topic><topic>Proto-Oncogene Proteins c-fos - genetics</topic><topic>Proto-Oncogene Proteins c-fos - physiology</topic><topic>Proto-oncogenes</topic><topic>Skeleton and joints</topic><topic>Space life sciences</topic><topic>Spleen cells</topic><topic>Stromal cells</topic><topic>Vertebrates: osteoarticular system, musculoskeletal system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Grigoriadis, Agamemnon E.</creatorcontrib><creatorcontrib>Wang, Zhao-Qi</creatorcontrib><creatorcontrib>Cecchini, Marco G.</creatorcontrib><creatorcontrib>Hofstetter, Willy</creatorcontrib><creatorcontrib>Felix, Rolf</creatorcontrib><creatorcontrib>Fleisch, Herbert A.</creatorcontrib><creatorcontrib>Wagner, Erwin F.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale In Context: High School</collection><collection>Gale in Context : Biography</collection><collection>Gale in Context : Opposing Viewpoints</collection><collection>Gale In Context: Canada</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Science (American Association for the Advancement of Science)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Grigoriadis, Agamemnon E.</au><au>Wang, Zhao-Qi</au><au>Cecchini, Marco G.</au><au>Hofstetter, Willy</au><au>Felix, Rolf</au><au>Fleisch, Herbert A.</au><au>Wagner, Erwin F.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>c-Fos: A Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling</atitle><jtitle>Science (American Association for the Advancement of Science)</jtitle><addtitle>Science</addtitle><date>1994-10-21</date><risdate>1994</risdate><volume>266</volume><issue>5184</issue><spage>443</spage><epage>448</epage><pages>443-448</pages><issn>0036-8075</issn><eissn>1095-9203</eissn><coden>SCIEAS</coden><abstract>Mice lacking the proto-oncogene c-fos develop the bone disease osteopetrosis. Fos mutant mice were found to have a block in the differentiation of bone-resorbing osteoclasts that was intrinsic to hematopoietic cells. Bone marrow transplantation rescued the osteopetrosis, and ectopic c-fos expression overcame this differentiation block. The lack of Fos also caused a lineage shift between osteoclasts and macrophages that resulted in increased numbers of bone marrow macrophages. These results identify Fos as a key regulator of osteoclast-macrophage lineage determination in vivo and provide insights into the molecular mechanisms underlying metabolic bone diseases.</abstract><cop>Washington, DC</cop><pub>American Society for the Advancement of Science</pub><pmid>7939685</pmid><doi>10.1126/science.7939685</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-8075 |
| ispartof | Science (American Association for the Advancement of Science), 1994-10, Vol.266 (5184), p.443-448 |
| issn | 0036-8075 1095-9203 |
| language | eng |
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| source | American Association for the Advancement of Science; Jstor Complete Legacy; MEDLINE |
| subjects | Animals Biological and medical sciences Bone marrow Bone Marrow Transplantation Bone Remodeling - physiology Bone resorption Bones Capsules Cell Differentiation Cells, Cultured Fundamental and applied biological sciences. Psychology Genes, fos Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Hematopoietic Stem Cells - cytology Macrophages Macrophages - cytology Mice Mice, Mutant Strains Osteoclasts Osteoclasts - cytology Osteogenesis Osteopetrosis Osteopetrosis - metabolism Osteopetrosis - pathology Progenitor cells Proto-Oncogene Proteins c-fos - genetics Proto-Oncogene Proteins c-fos - physiology Proto-oncogenes Skeleton and joints Space life sciences Spleen cells Stromal cells Vertebrates: osteoarticular system, musculoskeletal system |
| title | c-Fos: A Key Regulator of Osteoclast-Macrophage Lineage Determination and Bone Remodeling |
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