Presence of Cells of Fetal Origin in Maternal Circulation of Pregnant Women
Fetal cells can be identified by using the polymerase chain reaction to test for the presence of human Y-chromosome-specific ZFY and SRY gene DNA sequences in maternal peripheral blood of women who bear a male fetus. Thirty-one pregnant women were studied in the first trimester to determine when fet...
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| Veröffentlicht in: | Annals of the New York Academy of Sciences 1994-09, Vol.731 (1), p.237-241 |
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| creator | LIOU, JUI-DER HSIEH, T'SANG-T'ANG PAO, CHIA C. |
| description | Fetal cells can be identified by using the polymerase chain reaction to test for the presence of human Y-chromosome-specific ZFY and SRY gene DNA sequences in maternal peripheral blood of women who bear a male fetus. Thirty-one pregnant women were studied in the first trimester to determine when fetal cells become detectable in the maternal circulation. Among the 19 women whose peripheral blood samples were positive for Y-chromosome-specific DNA sequences, the presence of fetal cells was quite case-variable from the 6th to 12th gestational weeks. Twenty-eight women who had given birth to their first male babies were studied postpartum to determine when fetal cells disappear from the maternal circulation. Fetal cells can still be detected in maternal blood 10 months postpartum in some cases. These results suggest that identification of fetal cells in the maternal circulation is possible. Nevertheless, interpretation of fetal cells in maternal circulation should be handled very carefully with respect to when these fetal cells first became detectable and potential interference from previous pregnancies. |
| doi_str_mv | 10.1111/j.1749-6632.1994.tb55775.x |
| format | Article |
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Thirty-one pregnant women were studied in the first trimester to determine when fetal cells become detectable in the maternal circulation. Among the 19 women whose peripheral blood samples were positive for Y-chromosome-specific DNA sequences, the presence of fetal cells was quite case-variable from the 6th to 12th gestational weeks. Twenty-eight women who had given birth to their first male babies were studied postpartum to determine when fetal cells disappear from the maternal circulation. Fetal cells can still be detected in maternal blood 10 months postpartum in some cases. These results suggest that identification of fetal cells in the maternal circulation is possible. 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Thirty-one pregnant women were studied in the first trimester to determine when fetal cells become detectable in the maternal circulation. Among the 19 women whose peripheral blood samples were positive for Y-chromosome-specific DNA sequences, the presence of fetal cells was quite case-variable from the 6th to 12th gestational weeks. Twenty-eight women who had given birth to their first male babies were studied postpartum to determine when fetal cells disappear from the maternal circulation. Fetal cells can still be detected in maternal blood 10 months postpartum in some cases. These results suggest that identification of fetal cells in the maternal circulation is possible. Nevertheless, interpretation of fetal cells in maternal circulation should be handled very carefully with respect to when these fetal cells first became detectable and potential interference from previous pregnancies.</description><subject>DNA-Binding Proteins - genetics</subject><subject>Female</subject><subject>Fetus - cytology</subject><subject>Gestational Age</subject><subject>Humans</subject><subject>Kruppel-Like Transcription Factors</subject><subject>Male</subject><subject>Nuclear Proteins</subject><subject>Parity</subject><subject>Polymerase Chain Reaction - methods</subject><subject>Pregnancy</subject><subject>Pregnancy Trimester, First - blood</subject><subject>Sex Determination Analysis - methods</subject><subject>Sex-Determining Region Y Protein</subject><subject>Transcription Factors</subject><subject>Y Chromosome</subject><issn>0077-8923</issn><issn>1749-6632</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1r2zAUhkXZSLN0P2FgejF6Y1eyZH30ZrRhSUvapFs7Sq-EbB8VZ46dSg5N__1kEnI5qBBI6Dzn1eFB6JTghIR1vkyIYCrmnKYJUYolXZ5lQmTJ9ggND6VPaIixELFUKT1GX7xfYkxSycQADYRijKR8iGb3Djw0BUStjcZQ176_TKAzdbRw1UvVRGHfmQ5cE57GlSs2temqtum50PzSmKaLntoVNCfoszW1h6_7c4T-TH4-jq_j28X0Znx5GxcZ5SK2KRWKKG7DoJLkJYaMMStLbqXJKYNSmsyUtsC0pIpjKKAIkDA2tZTlQtER-r7LXbv2dQO-06vKF2F200C78VpwITkmOIBn_wWJlFJlQkoR0IsdWrjWewdWr121Mu5dE6x76Xqpe7O6N6t76XovXW9D87f9P5t8BeWhdW851H_s6m9VDe8fSNbz58uHoCskxLuEynewPSQY91dzQQP6NJ_q2e9fdDa7etBz-g-91qEL</recordid><startdate>199409</startdate><enddate>199409</enddate><creator>LIOU, JUI-DER</creator><creator>HSIEH, T'SANG-T'ANG</creator><creator>PAO, CHIA C.</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>7T5</scope><scope>C1K</scope><scope>H94</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>199409</creationdate><title>Presence of Cells of Fetal Origin in Maternal Circulation of Pregnant Women</title><author>LIOU, JUI-DER ; HSIEH, T'SANG-T'ANG ; PAO, CHIA C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5367-f2379196f74981bd0e544f8d6f8ab34ed8a5adfc03d3960ececbd07af2f34b793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>DNA-Binding Proteins - genetics</topic><topic>Female</topic><topic>Fetus - cytology</topic><topic>Gestational Age</topic><topic>Humans</topic><topic>Kruppel-Like Transcription Factors</topic><topic>Male</topic><topic>Nuclear Proteins</topic><topic>Parity</topic><topic>Polymerase Chain Reaction - methods</topic><topic>Pregnancy</topic><topic>Pregnancy Trimester, First - blood</topic><topic>Sex Determination Analysis - methods</topic><topic>Sex-Determining Region Y Protein</topic><topic>Transcription Factors</topic><topic>Y Chromosome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIOU, JUI-DER</creatorcontrib><creatorcontrib>HSIEH, T'SANG-T'ANG</creatorcontrib><creatorcontrib>PAO, CHIA C.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of the New York Academy of Sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIOU, JUI-DER</au><au>HSIEH, T'SANG-T'ANG</au><au>PAO, CHIA C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Presence of Cells of Fetal Origin in Maternal Circulation of Pregnant Women</atitle><jtitle>Annals of the New York Academy of Sciences</jtitle><addtitle>Ann N Y Acad Sci</addtitle><date>1994-09</date><risdate>1994</risdate><volume>731</volume><issue>1</issue><spage>237</spage><epage>241</epage><pages>237-241</pages><issn>0077-8923</issn><eissn>1749-6632</eissn><abstract>Fetal cells can be identified by using the polymerase chain reaction to test for the presence of human Y-chromosome-specific ZFY and SRY gene DNA sequences in maternal peripheral blood of women who bear a male fetus. 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Nevertheless, interpretation of fetal cells in maternal circulation should be handled very carefully with respect to when these fetal cells first became detectable and potential interference from previous pregnancies.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7944126</pmid><doi>10.1111/j.1749-6632.1994.tb55775.x</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0077-8923 |
| ispartof | Annals of the New York Academy of Sciences, 1994-09, Vol.731 (1), p.237-241 |
| issn | 0077-8923 1749-6632 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | DNA-Binding Proteins - genetics Female Fetus - cytology Gestational Age Humans Kruppel-Like Transcription Factors Male Nuclear Proteins Parity Polymerase Chain Reaction - methods Pregnancy Pregnancy Trimester, First - blood Sex Determination Analysis - methods Sex-Determining Region Y Protein Transcription Factors Y Chromosome |
| title | Presence of Cells of Fetal Origin in Maternal Circulation of Pregnant Women |
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