The effect of combined immunosuppression with systemic low-dose cyclosporin and topical fluocinolone acetonide on the survival of rat hind-limb allografts
Sixty rat hind-limb allotransplantations across strong histocompatibility barriers were performed. Group I (isograft controls), (Lewis-Brown-Norway [LBN] to LBN) limb transplantations were performed; Group II (rejection controls), LBN limbs transplanted to Lewis rat LEW recipients with no immunosupp...
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| Veröffentlicht in: | Annals of plastic surgery 1994-07, Vol.33 (1), p.57-65 |
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| container_title | Annals of plastic surgery |
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| creator | INCEOGLU, S SIEMIONOW, M CHICK, L CRAVEN, C. M LISTER, G. D |
| description | Sixty rat hind-limb allotransplantations across strong histocompatibility barriers were performed. Group I (isograft controls), (Lewis-Brown-Norway [LBN] to LBN) limb transplantations were performed; Group II (rejection controls), LBN limbs transplanted to Lewis rat LEW recipients with no immunosuppressive treatment; Group III (steroid group), fluocinolone acetonide (50 micrograms/ml) was applied topically; Group IV (cyclosporine group), 4 mg/kg of cyclosporine was administered subcutaneously daily; Group V (combination group), combined systemic cyclosporine with topical fluocinolone acetonide was administered daily. Group II: Limb rejection was present on the fourth day. Group III: Limb survival was extended for 3 weeks with no signs of skin rejection in 75% of animals. Group IV: Rejection was complete at 3 weeks. Group V: Limbs survived to 6 weeks. Topical steroid prevented skin rejection and delayed rejection of other components of the composite allograft. Combined treatment of topical steroid and low cyclosporine doses significantly extended survival rate of limb allografts. |
| doi_str_mv | 10.1097/00000637-199407000-00011 |
| format | Article |
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M ; LISTER, G. D</creator><creatorcontrib>INCEOGLU, S ; SIEMIONOW, M ; CHICK, L ; CRAVEN, C. M ; LISTER, G. D</creatorcontrib><description>Sixty rat hind-limb allotransplantations across strong histocompatibility barriers were performed. Group I (isograft controls), (Lewis-Brown-Norway [LBN] to LBN) limb transplantations were performed; Group II (rejection controls), LBN limbs transplanted to Lewis rat LEW recipients with no immunosuppressive treatment; Group III (steroid group), fluocinolone acetonide (50 micrograms/ml) was applied topically; Group IV (cyclosporine group), 4 mg/kg of cyclosporine was administered subcutaneously daily; Group V (combination group), combined systemic cyclosporine with topical fluocinolone acetonide was administered daily. Group II: Limb rejection was present on the fourth day. Group III: Limb survival was extended for 3 weeks with no signs of skin rejection in 75% of animals. Group IV: Rejection was complete at 3 weeks. Group V: Limbs survived to 6 weeks. Topical steroid prevented skin rejection and delayed rejection of other components of the composite allograft. Combined treatment of topical steroid and low cyclosporine doses significantly extended survival rate of limb allografts.</description><identifier>ISSN: 0148-7043</identifier><identifier>EISSN: 1536-3708</identifier><identifier>DOI: 10.1097/00000637-199407000-00011</identifier><identifier>PMID: 7944198</identifier><identifier>CODEN: APCSD4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Administration, Topical ; Animals ; Biological and medical sciences ; Cyclosporine - administration & dosage ; Cyclosporine - therapeutic use ; Drug Therapy, Combination ; Fluocinolone Acetonide - administration & dosage ; Fluocinolone Acetonide - therapeutic use ; Graft Rejection - immunology ; Graft Rejection - prevention & control ; Graft Survival - drug effects ; Hindlimb - transplantation ; Immunosuppression - methods ; Injections, Subcutaneous ; Medical sciences ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred BN ; Rats, Inbred Lew ; Skin, nail, hair, dermoskeleton ; Time Factors ; Transplantation, Homologous</subject><ispartof>Annals of plastic surgery, 1994-07, Vol.33 (1), p.57-65</ispartof><rights>1994 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c278t-b93e53aa98080d2313be97c57bf7cc8a1b4365377fae03a7102df7f1b49dd2093</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4235480$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7944198$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>INCEOGLU, S</creatorcontrib><creatorcontrib>SIEMIONOW, M</creatorcontrib><creatorcontrib>CHICK, L</creatorcontrib><creatorcontrib>CRAVEN, C. M</creatorcontrib><creatorcontrib>LISTER, G. D</creatorcontrib><title>The effect of combined immunosuppression with systemic low-dose cyclosporin and topical fluocinolone acetonide on the survival of rat hind-limb allografts</title><title>Annals of plastic surgery</title><addtitle>Ann Plast Surg</addtitle><description>Sixty rat hind-limb allotransplantations across strong histocompatibility barriers were performed. Group I (isograft controls), (Lewis-Brown-Norway [LBN] to LBN) limb transplantations were performed; Group II (rejection controls), LBN limbs transplanted to Lewis rat LEW recipients with no immunosuppressive treatment; Group III (steroid group), fluocinolone acetonide (50 micrograms/ml) was applied topically; Group IV (cyclosporine group), 4 mg/kg of cyclosporine was administered subcutaneously daily; Group V (combination group), combined systemic cyclosporine with topical fluocinolone acetonide was administered daily. Group II: Limb rejection was present on the fourth day. Group III: Limb survival was extended for 3 weeks with no signs of skin rejection in 75% of animals. Group IV: Rejection was complete at 3 weeks. Group V: Limbs survived to 6 weeks. Topical steroid prevented skin rejection and delayed rejection of other components of the composite allograft. Combined treatment of topical steroid and low cyclosporine doses significantly extended survival rate of limb allografts.</description><subject>Administration, Topical</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Cyclosporine - administration & dosage</subject><subject>Cyclosporine - therapeutic use</subject><subject>Drug Therapy, Combination</subject><subject>Fluocinolone Acetonide - administration & dosage</subject><subject>Fluocinolone Acetonide - therapeutic use</subject><subject>Graft Rejection - immunology</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Survival - drug effects</subject><subject>Hindlimb - transplantation</subject><subject>Immunosuppression - methods</subject><subject>Injections, Subcutaneous</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred BN</subject><subject>Rats, Inbred Lew</subject><subject>Skin, nail, hair, dermoskeleton</subject><subject>Time Factors</subject><subject>Transplantation, Homologous</subject><issn>0148-7043</issn><issn>1536-3708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kcGOFCEQhonRrOPqI5hwMN5aoeke4Gg2rpps4mU9d2goHAwNLUXvZl7Fp5VxxyEhBOqr-hM-QihnHzjT8iM7rb2QHdd6YLJdurY5f0Z2fBT7TkimnpMd44PqJBvES_IK8VcjejXsr8iV1MPAtdqRP_cHoOA92EqzpzYvc0jgaFiWLWXc1rUAYsiJPoZ6oHjECkuwNObHzmUEao82ZlxzCYma5GjNa7AmUh-3bEPKMSegxkLNKTigbVBtibiVh_DQsJZZTKWHkFwXwzJTE2P-WYyv-Jq88CYivDmf1-TH7ef7m6_d3fcv324-3XW2l6p2sxYwCmO0Yoq5XnAxg5Z2lLOX1irD50HsRyGlN8CEkZz1zkvfnrVzPdPimrx_mruW_HsDrNMS0EKMJkHecJJ7qXgvT6B6Am3JiAX8tJawmHKcOJtOWqb_WqaLlumfltb69pyxzQu4S-PZQ6u_O9cNtt_zxSQb8IINvRgHxcRf4RuZCQ</recordid><startdate>199407</startdate><enddate>199407</enddate><creator>INCEOGLU, S</creator><creator>SIEMIONOW, M</creator><creator>CHICK, L</creator><creator>CRAVEN, C. 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D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c278t-b93e53aa98080d2313be97c57bf7cc8a1b4365377fae03a7102df7f1b49dd2093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Administration, Topical</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Cyclosporine - administration & dosage</topic><topic>Cyclosporine - therapeutic use</topic><topic>Drug Therapy, Combination</topic><topic>Fluocinolone Acetonide - administration & dosage</topic><topic>Fluocinolone Acetonide - therapeutic use</topic><topic>Graft Rejection - immunology</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Survival - drug effects</topic><topic>Hindlimb - transplantation</topic><topic>Immunosuppression - methods</topic><topic>Injections, Subcutaneous</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred BN</topic><topic>Rats, Inbred Lew</topic><topic>Skin, nail, hair, dermoskeleton</topic><topic>Time Factors</topic><topic>Transplantation, Homologous</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>INCEOGLU, S</creatorcontrib><creatorcontrib>SIEMIONOW, M</creatorcontrib><creatorcontrib>CHICK, L</creatorcontrib><creatorcontrib>CRAVEN, C. M</creatorcontrib><creatorcontrib>LISTER, G. 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D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of combined immunosuppression with systemic low-dose cyclosporin and topical fluocinolone acetonide on the survival of rat hind-limb allografts</atitle><jtitle>Annals of plastic surgery</jtitle><addtitle>Ann Plast Surg</addtitle><date>1994-07</date><risdate>1994</risdate><volume>33</volume><issue>1</issue><spage>57</spage><epage>65</epage><pages>57-65</pages><issn>0148-7043</issn><eissn>1536-3708</eissn><coden>APCSD4</coden><abstract>Sixty rat hind-limb allotransplantations across strong histocompatibility barriers were performed. Group I (isograft controls), (Lewis-Brown-Norway [LBN] to LBN) limb transplantations were performed; Group II (rejection controls), LBN limbs transplanted to Lewis rat LEW recipients with no immunosuppressive treatment; Group III (steroid group), fluocinolone acetonide (50 micrograms/ml) was applied topically; Group IV (cyclosporine group), 4 mg/kg of cyclosporine was administered subcutaneously daily; Group V (combination group), combined systemic cyclosporine with topical fluocinolone acetonide was administered daily. Group II: Limb rejection was present on the fourth day. Group III: Limb survival was extended for 3 weeks with no signs of skin rejection in 75% of animals. Group IV: Rejection was complete at 3 weeks. Group V: Limbs survived to 6 weeks. Topical steroid prevented skin rejection and delayed rejection of other components of the composite allograft. Combined treatment of topical steroid and low cyclosporine doses significantly extended survival rate of limb allografts.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>7944198</pmid><doi>10.1097/00000637-199407000-00011</doi><tpages>9</tpages></addata></record> |
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| ispartof | Annals of plastic surgery, 1994-07, Vol.33 (1), p.57-65 |
| issn | 0148-7043 1536-3708 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Administration, Topical Animals Biological and medical sciences Cyclosporine - administration & dosage Cyclosporine - therapeutic use Drug Therapy, Combination Fluocinolone Acetonide - administration & dosage Fluocinolone Acetonide - therapeutic use Graft Rejection - immunology Graft Rejection - prevention & control Graft Survival - drug effects Hindlimb - transplantation Immunosuppression - methods Injections, Subcutaneous Medical sciences Pharmacology. Drug treatments Rats Rats, Inbred BN Rats, Inbred Lew Skin, nail, hair, dermoskeleton Time Factors Transplantation, Homologous |
| title | The effect of combined immunosuppression with systemic low-dose cyclosporin and topical fluocinolone acetonide on the survival of rat hind-limb allografts |
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