Thermal stability of low molecular weight urokinase during heat treatment. II: Effect of polymeric additives

Turbidimetric or light scattering assays can be used to determine the extent of aggregation in protein formulations. Using low molecular weight urokinase (LMW-UK) as a model protein, the effect of polymeric additives on heat-induced aggregation was evaluated. Previous work has shown that under 60 de...

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Veröffentlicht in:	Pharmaceutical research 1994-07, Vol.11 (7), p.1004-1008
Hauptverfasser:	VRKLJAN, M, FOSTER, T. M, POWERS, M. E, HENKIN, J, PORTER, W. R, STAACK, H, CARPENTER, J. F, MANNING, M. C
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Enzyme Stability General pharmacology Glycerol - pharmacology Hot Temperature Light Medical sciences Molecular Weight Nephelometry and Turbidimetry Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Polyethylene Glycols Polymers Povidone Protein Denaturation Protein Folding Scattering, Radiation Starch - pharmacology Urokinase-Type Plasminogen Activator - chemistry Urokinase-Type Plasminogen Activator - drug effects
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