Outcome in infants born to mothers with unexplained elevations of maternal serum α-fetoprotein
The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum alpha-fetoprotein was studied. Elevated maternal serum alpha-fetoprotein with normal amniotic fluid alpha-fetoprotein was found to be associated with an increased incidence of intrauterine growth ret...
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| Veröffentlicht in: | Pediatrics (Evanston) 1986-04, Vol.77 (4), p.582-586 |
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| container_title | Pediatrics (Evanston) |
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| creator | BURTON, B. K DILLARD, R. G |
| description | The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum alpha-fetoprotein was studied. Elevated maternal serum alpha-fetoprotein with normal amniotic fluid alpha-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum alpha-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum alpha-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations. |
| doi_str_mv | 10.1542/peds.77.4.582 |
| format | Article |
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K ; DILLARD, R. G</creator><creatorcontrib>BURTON, B. K ; DILLARD, R. G</creatorcontrib><description>The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum alpha-fetoprotein was studied. Elevated maternal serum alpha-fetoprotein with normal amniotic fluid alpha-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum alpha-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum alpha-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.77.4.582</identifier><identifier>PMID: 2421232</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>Elk Grove Village, IL: American Academy of Pediatrics</publisher><subject>Adult ; alpha-Fetoproteins - analysis ; Applied sciences ; Biological and medical sciences ; Birth Weight ; Congenital Abnormalities - diagnosis ; Delivery, Obstetric - methods ; Diseases of mother, fetus and pregnancy ; Exact sciences and technology ; Female ; Gestational Age ; Gynecology. Andrology. Obstetrics ; Humans ; Infant, Newborn ; Medical sciences ; Obstetric Labor Complications ; Other techniques and industries ; Pregnancy ; Pregnancy. Fetus. 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K</creatorcontrib><creatorcontrib>DILLARD, R. G</creatorcontrib><title>Outcome in infants born to mothers with unexplained elevations of maternal serum α-fetoprotein</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum alpha-fetoprotein was studied. Elevated maternal serum alpha-fetoprotein with normal amniotic fluid alpha-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum alpha-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum alpha-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations.</description><subject>Adult</subject><subject>alpha-Fetoproteins - analysis</subject><subject>Applied sciences</subject><subject>Biological and medical sciences</subject><subject>Birth Weight</subject><subject>Congenital Abnormalities - diagnosis</subject><subject>Delivery, Obstetric - methods</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Exact sciences and technology</subject><subject>Female</subject><subject>Gestational Age</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Medical sciences</subject><subject>Obstetric Labor Complications</subject><subject>Other techniques and industries</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. 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Placenta</topic><topic>Prospective Studies</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BURTON, B. K</creatorcontrib><creatorcontrib>DILLARD, R. G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BURTON, B. K</au><au>DILLARD, R. G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Outcome in infants born to mothers with unexplained elevations of maternal serum α-fetoprotein</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>1986-04-01</date><risdate>1986</risdate><volume>77</volume><issue>4</issue><spage>582</spage><epage>586</epage><pages>582-586</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>The outcome in infants without fetal neural tube defect born to mothers with elevated maternal serum alpha-fetoprotein was studied. Elevated maternal serum alpha-fetoprotein with normal amniotic fluid alpha-fetoprotein was found to be associated with an increased incidence of intrauterine growth retardation and nonneural tube congenital anomalies. There was no increased incidence of developmental disabilities in infants born to mothers with elevated maternal serum alpha-fetoprotein. It is speculated that adverse events occurring early in gestation may simultaneously result in congenital anomalies and subsequently elevated maternal serum alpha-fetoprotein, perhaps through disruption of the normal placental barrier between the fetal and maternal circulations.</abstract><cop>Elk Grove Village, IL</cop><pub>American Academy of Pediatrics</pub><pmid>2421232</pmid><doi>10.1542/peds.77.4.582</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0031-4005 |
| ispartof | Pediatrics (Evanston), 1986-04, Vol.77 (4), p.582-586 |
| issn | 0031-4005 1098-4275 |
| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Adult alpha-Fetoproteins - analysis Applied sciences Biological and medical sciences Birth Weight Congenital Abnormalities - diagnosis Delivery, Obstetric - methods Diseases of mother, fetus and pregnancy Exact sciences and technology Female Gestational Age Gynecology. Andrology. Obstetrics Humans Infant, Newborn Medical sciences Obstetric Labor Complications Other techniques and industries Pregnancy Pregnancy. Fetus. Placenta Prospective Studies Retrospective Studies |
| title | Outcome in infants born to mothers with unexplained elevations of maternal serum α-fetoprotein |
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