PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

PHAS-I is a heat-stable protein (relative molecular mass $\approx$12,400) found in many tissues. It is rapidly phosphorylated in rat adipocytes incubated with insulin or growth factors. Nonphosphorylated PHAS-I bound to initiation factor 4E (eIF-4E) and inhibited protein synthesis. Serine-64 in PHAS...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1994-10, Vol.266 (5185), p.653-656
Hauptverfasser:	Lin, Tai-An, Kong, Xianming, Timothy A. J. Haystead, Pause, Arnim, Belsham, Graham, Sonenberg, Nahum, Lawrence, John C.
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes Adipocytes - metabolism Animals Antibodies Antiserum Awards Biological and medical sciences Carrier Proteins Cell physiology Fundamental and applied biological sciences. Psychology Growth factors Homogenization Insulin Insulin - pharmacology Mice Mitogen-Activated Protein Kinase 1 Molecular and cellular biology Peptide Initiation Factors - isolation & purification Peptide Initiation Factors - metabolism Phosphoproteins - metabolism Phosphorylation Physiological aspects Protein Biosynthesis Protein synthesis Protein-Serine-Threonine Kinases - metabolism Protein-Tyrosine Kinases - metabolism Proteins Rats Recombinant Proteins - metabolism Resins Serine - metabolism Signal transduction Synthesis
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