Endothelin receptor type A signals both the accumulation of inositol phosphates and the inhibition of cyclic AMP generation in rat myometrium: stimulation and desensitization

In estradiol-dominated rat myometrium, endothelin (ET)-1 caused contraction and increased the accumulation of [3H]inositol phosphates (EC50 = 70 nM), with the sequential generation of inositol trisphosphate, inositol bisphosphate, and inositol monophosphate. There was a coincident early decrease in...

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Veröffentlicht in:	Molecular pharmacology 1994-09, Vol.46 (3), p.485-494
Hauptverfasser:	Khac, L D, Naze, S, Harbon, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate Cyclase Toxin Animals Cyclic AMP - antagonists & inhibitors Cyclic AMP - biosynthesis Dose-Response Relationship, Drug Endothelin Receptor Antagonists Endothelins - pharmacology Female Inositol Phosphates - metabolism Myometrium - drug effects Myometrium - metabolism Peptides, Cyclic - pharmacology Pertussis Toxin Rats Rats, Wistar Receptor, Endothelin A Receptors, Endothelin - genetics Signal Transduction - drug effects Signal Transduction - genetics Uterine Contraction - drug effects Vasoconstrictor Agents - pharmacology Viper Venoms - pharmacology Virulence Factors, Bordetella - pharmacology
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