Estrogen-induced proteins: A new class of regulatory substances
The discovery of estrogen-induced growth factors (estromedins) identified a missing link in understanding endocrine regulation. Estromedins are probably not on in vitro mitogens or auto-/paracrine growth regulators but play an important endocrine regulatory role. A review of the literature and our o...
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| Veröffentlicht in: | Medical hypotheses 1986-03, Vol.19 (3), p.199-228 |
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| creator | Biro, J.C. |
| description | The discovery of estrogen-induced growth factors (estromedins) identified a missing link in understanding endocrine regulation. Estromedins are probably not on
in vitro
mitogens or auto-/paracrine growth regulators but play an important endocrine regulatory role. A review of the literature and our own previous
in vivo
endocrine experiments with uterus and uterine extracts support this concept. We have also discussed the effects of some other newly discovered endocrine regulators on the synthesis/release and peripheral action of gonadotropins and lactogens. We conclude that our view on endocrine regulation is fundamentally changing. In addition to the classical endocrine axis (hypothalamus-pituitary-peripheral tissue) several new factors and conditions have to be taken into consideration to understand the regulation of an endocrine effect on a target organ. |
| doi_str_mv | 10.1016/0306-9877(86)90069-1 |
| format | Article |
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in vitro
mitogens or auto-/paracrine growth regulators but play an important endocrine regulatory role. A review of the literature and our own previous
in vivo
endocrine experiments with uterus and uterine extracts support this concept. We have also discussed the effects of some other newly discovered endocrine regulators on the synthesis/release and peripheral action of gonadotropins and lactogens. We conclude that our view on endocrine regulation is fundamentally changing. In addition to the classical endocrine axis (hypothalamus-pituitary-peripheral tissue) several new factors and conditions have to be taken into consideration to understand the regulation of an endocrine effect on a target organ.</description><identifier>ISSN: 0306-9877</identifier><identifier>EISSN: 1532-2777</identifier><identifier>DOI: 10.1016/0306-9877(86)90069-1</identifier><identifier>PMID: 3515132</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Animals ; Antigens, Polyomavirus Transforming ; Antigens, Viral, Tumor - physiology ; Breast - physiology ; Cell Differentiation ; Endocrine Glands - physiology ; Estradiol - pharmacology ; Estrogens - physiology ; Feedback ; Female ; Growth Substances - physiology ; Hormones - physiology ; Humans ; Hysterectomy ; Mammary Glands, Animal - physiology ; Mastectomy ; Mitogens ; Molecular Weight ; Oncogene Proteins, Viral - physiology ; Ovariectomy ; Ovary - physiology ; Peptides - physiology ; Pituitary Hormones - physiology ; Pregnancy ; Uterine Neoplasms - physiopathology ; Uterus - physiology</subject><ispartof>Medical hypotheses, 1986-03, Vol.19 (3), p.199-228</ispartof><rights>1986</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-6bc6a4d2046e10530e4340aefccd6b138addee2a3722a5d8865174bcc237b5563</citedby><cites>FETCH-LOGICAL-c357t-6bc6a4d2046e10530e4340aefccd6b138addee2a3722a5d8865174bcc237b5563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0306987786900691$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3515132$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Biro, J.C.</creatorcontrib><title>Estrogen-induced proteins: A new class of regulatory substances</title><title>Medical hypotheses</title><addtitle>Med Hypotheses</addtitle><description>The discovery of estrogen-induced growth factors (estromedins) identified a missing link in understanding endocrine regulation. Estromedins are probably not on
in vitro
mitogens or auto-/paracrine growth regulators but play an important endocrine regulatory role. A review of the literature and our own previous
in vivo
endocrine experiments with uterus and uterine extracts support this concept. We have also discussed the effects of some other newly discovered endocrine regulators on the synthesis/release and peripheral action of gonadotropins and lactogens. We conclude that our view on endocrine regulation is fundamentally changing. In addition to the classical endocrine axis (hypothalamus-pituitary-peripheral tissue) several new factors and conditions have to be taken into consideration to understand the regulation of an endocrine effect on a target organ.</description><subject>Animals</subject><subject>Antigens, Polyomavirus Transforming</subject><subject>Antigens, Viral, Tumor - physiology</subject><subject>Breast - physiology</subject><subject>Cell Differentiation</subject><subject>Endocrine Glands - physiology</subject><subject>Estradiol - pharmacology</subject><subject>Estrogens - physiology</subject><subject>Feedback</subject><subject>Female</subject><subject>Growth Substances - physiology</subject><subject>Hormones - physiology</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Mammary Glands, Animal - physiology</subject><subject>Mastectomy</subject><subject>Mitogens</subject><subject>Molecular Weight</subject><subject>Oncogene Proteins, Viral - physiology</subject><subject>Ovariectomy</subject><subject>Ovary - physiology</subject><subject>Peptides - physiology</subject><subject>Pituitary Hormones - physiology</subject><subject>Pregnancy</subject><subject>Uterine Neoplasms - physiopathology</subject><subject>Uterus - physiology</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtPwzAQhC0EKqXwD0DKCcEh4LddDqCqKg-pEhc4W469qYzSpNgJqP-eRK165DSHmZ3d_RC6JPiOYCLvMcMyn2qlbrS8nWIspzk5QmMiGM2pUuoYjQ-RU3SW0hfGeMqZHqERE0QQRsfoaZHa2KygzkPtOwc-28SmhVCnh2yW1fCbucqmlDVlFmHVVbZt4jZLXZFaWztI5-iktFWCi71O0Ofz4mP-mi_fX97ms2XumFBtLgsnLfcUcwkEC4aBM44tlM55WRCmrfcA1DJFqRVeaymI4oVzlKlCCMkm6HrX25_33UFqzTokB1Vla2i6ZJRUinHN-yDfBV1sUopQmk0Maxu3hmAzcDMDFDNAMbrXgZsh_djVvr8r1uAPQ3tQvf-486F_8idANMkF6An4EMG1xjfh_wV_h3R8Kg</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>Biro, J.C.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860301</creationdate><title>Estrogen-induced proteins: A new class of regulatory substances</title><author>Biro, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-6bc6a4d2046e10530e4340aefccd6b138addee2a3722a5d8865174bcc237b5563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Antigens, Polyomavirus Transforming</topic><topic>Antigens, Viral, Tumor - physiology</topic><topic>Breast - physiology</topic><topic>Cell Differentiation</topic><topic>Endocrine Glands - physiology</topic><topic>Estradiol - pharmacology</topic><topic>Estrogens - physiology</topic><topic>Feedback</topic><topic>Female</topic><topic>Growth Substances - physiology</topic><topic>Hormones - physiology</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Mammary Glands, Animal - physiology</topic><topic>Mastectomy</topic><topic>Mitogens</topic><topic>Molecular Weight</topic><topic>Oncogene Proteins, Viral - physiology</topic><topic>Ovariectomy</topic><topic>Ovary - physiology</topic><topic>Peptides - physiology</topic><topic>Pituitary Hormones - physiology</topic><topic>Pregnancy</topic><topic>Uterine Neoplasms - physiopathology</topic><topic>Uterus - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Biro, J.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Biro, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Estrogen-induced proteins: A new class of regulatory substances</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>19</volume><issue>3</issue><spage>199</spage><epage>228</epage><pages>199-228</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>The discovery of estrogen-induced growth factors (estromedins) identified a missing link in understanding endocrine regulation. Estromedins are probably not on
in vitro
mitogens or auto-/paracrine growth regulators but play an important endocrine regulatory role. A review of the literature and our own previous
in vivo
endocrine experiments with uterus and uterine extracts support this concept. We have also discussed the effects of some other newly discovered endocrine regulators on the synthesis/release and peripheral action of gonadotropins and lactogens. We conclude that our view on endocrine regulation is fundamentally changing. In addition to the classical endocrine axis (hypothalamus-pituitary-peripheral tissue) several new factors and conditions have to be taken into consideration to understand the regulation of an endocrine effect on a target organ.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>3515132</pmid><doi>10.1016/0306-9877(86)90069-1</doi><tpages>30</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0306-9877 |
| ispartof | Medical hypotheses, 1986-03, Vol.19 (3), p.199-228 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Antigens, Polyomavirus Transforming Antigens, Viral, Tumor - physiology Breast - physiology Cell Differentiation Endocrine Glands - physiology Estradiol - pharmacology Estrogens - physiology Feedback Female Growth Substances - physiology Hormones - physiology Humans Hysterectomy Mammary Glands, Animal - physiology Mastectomy Mitogens Molecular Weight Oncogene Proteins, Viral - physiology Ovariectomy Ovary - physiology Peptides - physiology Pituitary Hormones - physiology Pregnancy Uterine Neoplasms - physiopathology Uterus - physiology |
| title | Estrogen-induced proteins: A new class of regulatory substances |
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