Pharmacokinetics and Pharmacodynamics of Pentopril, a New Angiotensin-Converting-Enzyme Inhibitor in Humans

In a single, ascending‐dose tolerance study, nine healthy volunteers were given oral pentopril 50 to 750 mg (CGS 13945) in groups of three each. Disposition characteristics of pentopril and its active metabolite (CGS 13934) were determined using plasma concentration and urinary excretion data. The d...

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Veröffentlicht in:	Journal of clinical pharmacology 1986-03, Vol.26 (3), p.156-164
Hauptverfasser:	Rakhit, Ashok, Hurley, Margaret E., Tipnis, Vijay, Coleman, Jean, Rommel, Alan, Brunner, Hans R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Angiotensin I - pharmacology Angiotensin-Converting Enzyme Inhibitors Antihypertensive agents Biological and medical sciences Biotransformation Blood Pressure - drug effects Cardiovascular system Drug Administration Schedule Humans Indoles - administration & dosage Indoles - metabolism Indoles - pharmacology Intestinal Absorption Kinetics Male Mathematics Medical sciences Models, Biological Peptidyl-Dipeptidase A - blood Pharmacology. Drug treatments
Online-Zugang:	Volltext
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