Cytoplasmic Estrogen and Progesterone Receptors as Prognostic Parameters in Primary Endometrial Carcinoma
Eighty-six cases of primary endometrial carcinoma were assayed for the presence or absence of cytoplasmic estrogen and progesterone receptors by the saturation point dextrancoated charcoal assay. The levels of cytoplasmic progesterone receptors and estrogen receptors were analyzed according to clini...
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| Veröffentlicht in: | Obstetrics and gynecology (New York. 1953) 1986-04, Vol.67 (4), p.463-467 |
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| container_title | Obstetrics and gynecology (New York. 1953) |
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| creator | LIAO, BENEDICT S TWIGGS, LEO B LEUNG, BENJAMIN S YU, WINSTON C.Y POTISH, ROGER A PREM, KONALD A |
| description | Eighty-six cases of primary endometrial carcinoma were assayed for the presence or absence of cytoplasmic estrogen and progesterone receptors by the saturation point dextrancoated charcoal assay. The levels of cytoplasmic progesterone receptors and estrogen receptors were analyzed according to clinical stage, histologic type and grade of the tumor, presence or absence of lymph node metastases, myometrial invasion, and survival. The cases were divided into positive and negative receptor groups with levels chosen of greater than 10 fmol/mg of cystosol protein for progesterone receptor and 5 fmol/mg of cytosol protein for estrogen receptor as discrimination points. Statistically significant survival differences were found between estrogen receptor positive versus estrogen receptor negative patients, progesterone receptor positive versus progesterone receptor negative patients, and estrogen positive-progesterone receptor positive versus estrogen negative-progesterone receptor negative patients. Mean cytoplasmic estrogen and progesterone receptor levels were inversely proportional to grade. This report suggests that treatment protocols should be devised to reflect the prognostic significance of receptor status. |
| format | Article |
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The levels of cytoplasmic progesterone receptors and estrogen receptors were analyzed according to clinical stage, histologic type and grade of the tumor, presence or absence of lymph node metastases, myometrial invasion, and survival. The cases were divided into positive and negative receptor groups with levels chosen of greater than 10 fmol/mg of cystosol protein for progesterone receptor and 5 fmol/mg of cytosol protein for estrogen receptor as discrimination points. Statistically significant survival differences were found between estrogen receptor positive versus estrogen receptor negative patients, progesterone receptor positive versus progesterone receptor negative patients, and estrogen positive-progesterone receptor positive versus estrogen negative-progesterone receptor negative patients. Mean cytoplasmic estrogen and progesterone receptor levels were inversely proportional to grade. This report suggests that treatment protocols should be devised to reflect the prognostic significance of receptor status.</description><identifier>ISSN: 0029-7844</identifier><identifier>EISSN: 1873-233X</identifier><identifier>PMID: 3960417</identifier><identifier>CODEN: OBGNAS</identifier><language>eng</language><publisher>New York, NY: The American College of Obstetricians and Gynecologists</publisher><subject>Adenocarcinoma - analysis ; Adenocarcinoma - mortality ; Adenocarcinoma - pathology ; Biological and medical sciences ; Carcinoma, Squamous Cell - analysis ; Carcinoma, Squamous Cell - mortality ; Carcinoma, Squamous Cell - pathology ; Cytoplasm - analysis ; Female ; Female genital diseases ; Gynecology. Andrology. Obstetrics ; Humans ; Lymphatic Metastasis ; Medical sciences ; Menopause ; Neoplasm Invasiveness ; Neoplasm Staging ; Prognosis ; Receptors, Estrogen - analysis ; Receptors, Progesterone - analysis ; Tumors ; Uterine Neoplasms - analysis ; Uterine Neoplasms - mortality ; Uterine Neoplasms - pathology</subject><ispartof>Obstetrics and gynecology (New York. 1953), 1986-04, Vol.67 (4), p.463-467</ispartof><rights>1986 The American College of Obstetricians and Gynecologists</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7865728$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3960417$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIAO, BENEDICT S</creatorcontrib><creatorcontrib>TWIGGS, LEO B</creatorcontrib><creatorcontrib>LEUNG, BENJAMIN S</creatorcontrib><creatorcontrib>YU, WINSTON C.Y</creatorcontrib><creatorcontrib>POTISH, ROGER A</creatorcontrib><creatorcontrib>PREM, KONALD A</creatorcontrib><title>Cytoplasmic Estrogen and Progesterone Receptors as Prognostic Parameters in Primary Endometrial Carcinoma</title><title>Obstetrics and gynecology (New York. 1953)</title><addtitle>Obstet Gynecol</addtitle><description>Eighty-six cases of primary endometrial carcinoma were assayed for the presence or absence of cytoplasmic estrogen and progesterone receptors by the saturation point dextrancoated charcoal assay. The levels of cytoplasmic progesterone receptors and estrogen receptors were analyzed according to clinical stage, histologic type and grade of the tumor, presence or absence of lymph node metastases, myometrial invasion, and survival. The cases were divided into positive and negative receptor groups with levels chosen of greater than 10 fmol/mg of cystosol protein for progesterone receptor and 5 fmol/mg of cytosol protein for estrogen receptor as discrimination points. Statistically significant survival differences were found between estrogen receptor positive versus estrogen receptor negative patients, progesterone receptor positive versus progesterone receptor negative patients, and estrogen positive-progesterone receptor positive versus estrogen negative-progesterone receptor negative patients. Mean cytoplasmic estrogen and progesterone receptor levels were inversely proportional to grade. This report suggests that treatment protocols should be devised to reflect the prognostic significance of receptor status.</description><subject>Adenocarcinoma - analysis</subject><subject>Adenocarcinoma - mortality</subject><subject>Adenocarcinoma - pathology</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Squamous Cell - analysis</subject><subject>Carcinoma, Squamous Cell - mortality</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cytoplasm - analysis</subject><subject>Female</subject><subject>Female genital diseases</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Lymphatic Metastasis</subject><subject>Medical sciences</subject><subject>Menopause</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Staging</subject><subject>Prognosis</subject><subject>Receptors, Estrogen - analysis</subject><subject>Receptors, Progesterone - analysis</subject><subject>Tumors</subject><subject>Uterine Neoplasms - analysis</subject><subject>Uterine Neoplasms - mortality</subject><subject>Uterine Neoplasms - pathology</subject><issn>0029-7844</issn><issn>1873-233X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kNtKxDAQhoso67r6CEIvxLtCmrQ5XEpZD7DgIgrelWmautE0qUmL7NubdYtXc_i_GWb-k2SZc0YyTMj7abJECIuM8aI4Ty5C-EQI5VSQRbIggqIiZ8tEV_vRDQZCr2W6DqN3H8qmYNt0e0jDqLyzKn1RUg2j8yGF8KdYF8Y4sQUPvYpQSLWNgu7B79O1bV3seg0mrcBLbV0Pl8lZByaoqzmukrf79Wv1mG2eH56qu002YI5wJkRXSslyRUVLATPUNZI1bVMw3jFeFrRUMi8aJUVTthwkRYJ0kuAOWC5QocgquT3uHbz7nuIHda-DVMaAVW4KNaOMIYZoBK9ncGp61dbD8fp69ibqN7MOQYLpPFipwz_GOC0Z5hErjtiPMwcjvsz0o3y9U2DGXR0tRxSXKMsFj2tjlR1amPwCLcF_pQ</recordid><startdate>198604</startdate><enddate>198604</enddate><creator>LIAO, BENEDICT S</creator><creator>TWIGGS, LEO B</creator><creator>LEUNG, BENJAMIN S</creator><creator>YU, WINSTON C.Y</creator><creator>POTISH, ROGER A</creator><creator>PREM, KONALD A</creator><general>The American College of Obstetricians and Gynecologists</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198604</creationdate><title>Cytoplasmic Estrogen and Progesterone Receptors as Prognostic Parameters in Primary Endometrial Carcinoma</title><author>LIAO, BENEDICT S ; TWIGGS, LEO B ; LEUNG, BENJAMIN S ; YU, WINSTON C.Y ; POTISH, ROGER A ; PREM, KONALD A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2802-99f5cc71e69d6a270fbc7bdb478f785465ec14bec9b5d8ac6093fc32fa71904e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adenocarcinoma - analysis</topic><topic>Adenocarcinoma - mortality</topic><topic>Adenocarcinoma - pathology</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Squamous Cell - analysis</topic><topic>Carcinoma, Squamous Cell - mortality</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cytoplasm - analysis</topic><topic>Female</topic><topic>Female genital diseases</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Lymphatic Metastasis</topic><topic>Medical sciences</topic><topic>Menopause</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Staging</topic><topic>Prognosis</topic><topic>Receptors, Estrogen - analysis</topic><topic>Receptors, Progesterone - analysis</topic><topic>Tumors</topic><topic>Uterine Neoplasms - analysis</topic><topic>Uterine Neoplasms - mortality</topic><topic>Uterine Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIAO, BENEDICT S</creatorcontrib><creatorcontrib>TWIGGS, LEO B</creatorcontrib><creatorcontrib>LEUNG, BENJAMIN S</creatorcontrib><creatorcontrib>YU, WINSTON C.Y</creatorcontrib><creatorcontrib>POTISH, ROGER A</creatorcontrib><creatorcontrib>PREM, KONALD A</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIAO, BENEDICT S</au><au>TWIGGS, LEO B</au><au>LEUNG, BENJAMIN S</au><au>YU, WINSTON C.Y</au><au>POTISH, ROGER A</au><au>PREM, KONALD A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cytoplasmic Estrogen and Progesterone Receptors as Prognostic Parameters in Primary Endometrial Carcinoma</atitle><jtitle>Obstetrics and gynecology (New York. 1953)</jtitle><addtitle>Obstet Gynecol</addtitle><date>1986-04</date><risdate>1986</risdate><volume>67</volume><issue>4</issue><spage>463</spage><epage>467</epage><pages>463-467</pages><issn>0029-7844</issn><eissn>1873-233X</eissn><coden>OBGNAS</coden><abstract>Eighty-six cases of primary endometrial carcinoma were assayed for the presence or absence of cytoplasmic estrogen and progesterone receptors by the saturation point dextrancoated charcoal assay. The levels of cytoplasmic progesterone receptors and estrogen receptors were analyzed according to clinical stage, histologic type and grade of the tumor, presence or absence of lymph node metastases, myometrial invasion, and survival. The cases were divided into positive and negative receptor groups with levels chosen of greater than 10 fmol/mg of cystosol protein for progesterone receptor and 5 fmol/mg of cytosol protein for estrogen receptor as discrimination points. Statistically significant survival differences were found between estrogen receptor positive versus estrogen receptor negative patients, progesterone receptor positive versus progesterone receptor negative patients, and estrogen positive-progesterone receptor positive versus estrogen negative-progesterone receptor negative patients. Mean cytoplasmic estrogen and progesterone receptor levels were inversely proportional to grade. This report suggests that treatment protocols should be devised to reflect the prognostic significance of receptor status.</abstract><cop>New York, NY</cop><pub>The American College of Obstetricians and Gynecologists</pub><pmid>3960417</pmid><tpages>5</tpages></addata></record> |
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| ispartof | Obstetrics and gynecology (New York. 1953), 1986-04, Vol.67 (4), p.463-467 |
| issn | 0029-7844 1873-233X |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adenocarcinoma - analysis Adenocarcinoma - mortality Adenocarcinoma - pathology Biological and medical sciences Carcinoma, Squamous Cell - analysis Carcinoma, Squamous Cell - mortality Carcinoma, Squamous Cell - pathology Cytoplasm - analysis Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Medical sciences Menopause Neoplasm Invasiveness Neoplasm Staging Prognosis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Tumors Uterine Neoplasms - analysis Uterine Neoplasms - mortality Uterine Neoplasms - pathology |
| title | Cytoplasmic Estrogen and Progesterone Receptors as Prognostic Parameters in Primary Endometrial Carcinoma |
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