Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid
Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and live...
Gespeichert in:
| Veröffentlicht in: | Journal of pharmaceutical sciences 1986-02, Vol.75 (2), p.193-194 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 194 |
|---|---|
| container_issue | 2 |
| container_start_page | 193 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 75 |
| creator | Matsushita, Yasuo Tsukiori, Mariko Suzuki, Tatsuo Moriguchi, Ikuo |
| description | Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients. |
| doi_str_mv | 10.1002/jps.2600750220 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_76769549</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0022354915470303</els_id><sourcerecordid>76769549</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4560-c49466911fb0b633d53ff5eeedb4b0c9b9670ea584a2ceae433c07b226de59d73</originalsourceid><addsrcrecordid>eNqFkU2P0zAQhi0EWsrClRtSDohbytiO7fpYFba7pcBKy9fNcuwJeEmTYjcs_fe4SlXEAXEZSzPPO555h5CnFKYUgL283aYpkwBKAGNwj0yoYFBKoOo-mWSAlVxU-iF5lNItAEgQ4oyccS1mmrMJWc7betiErrzq_ODQF4tvtvuKqeib4qId-ojJYeewuNmi20V7yNPyeh-xw3rY7WNwxdwF_5g8aGyb8MnxPScfL15_WFyW6_fLq8V8XbpKSMhRV1JqSpsaasm5F7xpBCL6uqrB6VpLBWjFrLLMocWKcweqZkx6FNorfk5ejH23sf8xYNqZTcgTtq3tsB-SUVJJnRfO4HQEXexTitiYbQwbG_eGgjk4Z7Jz5o9zWfDs2HmoN-hP-NGqXH9-rNvkbNtE27mQTpiaKSkpzZgesbvQ4v4_n5rV9c1fI5SjNqQd_jppbfxupOJKmM_vlubtpy_VevVqZd5kfjbymB3_GTCa5MLhWj7EfC3j-_CvbX8DDNqoGQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>76769549</pqid></control><display><type>article</type><title>Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Alma/SFX Local Collection</source><creator>Matsushita, Yasuo ; Tsukiori, Mariko ; Suzuki, Tatsuo ; Moriguchi, Ikuo</creator><creatorcontrib>Matsushita, Yasuo ; Tsukiori, Mariko ; Suzuki, Tatsuo ; Moriguchi, Ikuo</creatorcontrib><description>Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600750220</identifier><identifier>PMID: 3958932</identifier><identifier>CODEN: JPMSAE</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Buffers ; Cattle ; Dogs ; Fluorescent Dyes ; General pharmacology ; Humans ; Kidney Diseases - blood ; Liver Diseases - blood ; Medical sciences ; Pharmacology. Drug treatments ; Physicochemical properties. Structure-activity relationships ; Pyrenes - analysis ; Rabbits ; Serum Albumin ; Serum Albumin, Bovine ; Species Specificity ; Spectrometry, Fluorescence</subject><ispartof>Journal of pharmaceutical sciences, 1986-02, Vol.75 (2), p.193-194</ispartof><rights>1986 Wiley Periodicals, Inc. and the American Pharmacists Association</rights><rights>Copyright © 1986 Wiley‐Liss, Inc., A Wiley Company</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4560-c49466911fb0b633d53ff5eeedb4b0c9b9670ea584a2ceae433c07b226de59d73</citedby><cites>FETCH-LOGICAL-c4560-c49466911fb0b633d53ff5eeedb4b0c9b9670ea584a2ceae433c07b226de59d73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600750220$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600750220$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7876611$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3958932$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matsushita, Yasuo</creatorcontrib><creatorcontrib>Tsukiori, Mariko</creatorcontrib><creatorcontrib>Suzuki, Tatsuo</creatorcontrib><creatorcontrib>Moriguchi, Ikuo</creatorcontrib><title>Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Buffers</subject><subject>Cattle</subject><subject>Dogs</subject><subject>Fluorescent Dyes</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Kidney Diseases - blood</subject><subject>Liver Diseases - blood</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemical properties. Structure-activity relationships</subject><subject>Pyrenes - analysis</subject><subject>Rabbits</subject><subject>Serum Albumin</subject><subject>Serum Albumin, Bovine</subject><subject>Species Specificity</subject><subject>Spectrometry, Fluorescence</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU2P0zAQhi0EWsrClRtSDohbytiO7fpYFba7pcBKy9fNcuwJeEmTYjcs_fe4SlXEAXEZSzPPO555h5CnFKYUgL283aYpkwBKAGNwj0yoYFBKoOo-mWSAlVxU-iF5lNItAEgQ4oyccS1mmrMJWc7betiErrzq_ODQF4tvtvuKqeib4qId-ojJYeewuNmi20V7yNPyeh-xw3rY7WNwxdwF_5g8aGyb8MnxPScfL15_WFyW6_fLq8V8XbpKSMhRV1JqSpsaasm5F7xpBCL6uqrB6VpLBWjFrLLMocWKcweqZkx6FNorfk5ejH23sf8xYNqZTcgTtq3tsB-SUVJJnRfO4HQEXexTitiYbQwbG_eGgjk4Z7Jz5o9zWfDs2HmoN-hP-NGqXH9-rNvkbNtE27mQTpiaKSkpzZgesbvQ4v4_n5rV9c1fI5SjNqQd_jppbfxupOJKmM_vlubtpy_VevVqZd5kfjbymB3_GTCa5MLhWj7EfC3j-_CvbX8DDNqoGQ</recordid><startdate>198602</startdate><enddate>198602</enddate><creator>Matsushita, Yasuo</creator><creator>Tsukiori, Mariko</creator><creator>Suzuki, Tatsuo</creator><creator>Moriguchi, Ikuo</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><general>American Pharmaceutical Association</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198602</creationdate><title>Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid</title><author>Matsushita, Yasuo ; Tsukiori, Mariko ; Suzuki, Tatsuo ; Moriguchi, Ikuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4560-c49466911fb0b633d53ff5eeedb4b0c9b9670ea584a2ceae433c07b226de59d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Buffers</topic><topic>Cattle</topic><topic>Dogs</topic><topic>Fluorescent Dyes</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Kidney Diseases - blood</topic><topic>Liver Diseases - blood</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemical properties. Structure-activity relationships</topic><topic>Pyrenes - analysis</topic><topic>Rabbits</topic><topic>Serum Albumin</topic><topic>Serum Albumin, Bovine</topic><topic>Species Specificity</topic><topic>Spectrometry, Fluorescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matsushita, Yasuo</creatorcontrib><creatorcontrib>Tsukiori, Mariko</creatorcontrib><creatorcontrib>Suzuki, Tatsuo</creatorcontrib><creatorcontrib>Moriguchi, Ikuo</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matsushita, Yasuo</au><au>Tsukiori, Mariko</au><au>Suzuki, Tatsuo</au><au>Moriguchi, Ikuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1986-02</date><risdate>1986</risdate><volume>75</volume><issue>2</issue><spage>193</spage><epage>194</epage><pages>193-194</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><coden>JPMSAE</coden><abstract>Changes in the fluorescence spectra and quantum yield of 1-pyrenebutyric acid (1) induced by human, bovine, rabbit, and dog serum albumins and healthy adult serum, liver-disease patient serum, and renal-disease patient serum were compared at pH 7.4. Human serum albumin, healthy adult serum, and liver-disease patient serum caused marked quenching of the fluorescence of 1-pyrenebutyric acid. On the contrary, bovine, rabbit, and dog serum albumins increased the fluorescence intensity. Renal-disease patient serum also enhanced the intensity but caused quenching of the fluorescence after treatment with charcoal. Thus, 1-pyrenebutyric acid clearly shows interspecies differences in the environment or the structure of the binding site on serum albumin between humans and other animals. Furthermore, it is suggested that some substance which influences the character of the binding site for 1-pyrenebutyric acid exists in the serum of renal-disease patients.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>3958932</pmid><doi>10.1002/jps.2600750220</doi><tpages>2</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0022-3549 |
| ispartof | Journal of pharmaceutical sciences, 1986-02, Vol.75 (2), p.193-194 |
| issn | 0022-3549 1520-6017 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_76769549 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Alma/SFX Local Collection |
| subjects | Animals Biological and medical sciences Buffers Cattle Dogs Fluorescent Dyes General pharmacology Humans Kidney Diseases - blood Liver Diseases - blood Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Pyrenes - analysis Rabbits Serum Albumin Serum Albumin, Bovine Species Specificity Spectrometry, Fluorescence |
| title | Albumin-Induced Changes of Fluorescence Spectra of 1-Pyrenebutyric Acid |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-09T06%3A27%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Albumin-Induced%20Changes%20of%20Fluorescence%20Spectra%20of%201-Pyrenebutyric%20Acid&rft.jtitle=Journal%20of%20pharmaceutical%20sciences&rft.au=Matsushita,%20Yasuo&rft.date=1986-02&rft.volume=75&rft.issue=2&rft.spage=193&rft.epage=194&rft.pages=193-194&rft.issn=0022-3549&rft.eissn=1520-6017&rft.coden=JPMSAE&rft_id=info:doi/10.1002/jps.2600750220&rft_dat=%3Cproquest_cross%3E76769549%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=76769549&rft_id=info:pmid/3958932&rft_els_id=S0022354915470303&rfr_iscdi=true |