Existence of High Abundance Antiproliferative mRNA's in Senescent Human Diploid Fibroblasts

Polyadenylated RNA isolated from senescent human diploid fibroblasts (HDF) inhibited DNA synthesis in proliferation-competent cells after microinjection, whereas polyadenylated RNA from young HDF had no inhibitory effect. Polyadenylated RNA from young cells made quiescent by removal of serum growth...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-04, Vol.232 (4748), p.393-395
Hauptverfasser:	Lumpkin, C. K., McClung, J. Keith, Pereira-Smith, Olivia M., Smith, James R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Cell cycle Cell Division - drug effects Cell fusion Cell growth Cell research Cell Survival Cellular senescence Cytological research Diploidy DNA DNA - biosynthesis Fibroblasts Fibroblasts - physiology Genetics Humans Medical research Messenger RNA Microinjections Oncogenes Poly A - isolation & purification Poly A - pharmacology Poly A - physiology Proteins RNA RNA - isolation & purification RNA - pharmacology RNA - physiology RNA, Messenger - isolation & purification RNA, Messenger - pharmacology RNA, Messenger - physiology Somatic cells
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