Identification and Characterization of the Protein Encoded by the Human N-myc Oncogene

The human N-myc gene is related to the c-myc proto-oncogene, and has been shown to have transforming potential in vitro. Many studies have reported amplification of N-myc in human neuroblastoma and retinoblastoma cell lines. In primary tumors, amplification of the gene was found to correlate directl...

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Veröffentlicht in:	Science (American Association for the Advancement of Science) 1986-05, Vol.232 (4751), p.768-772
Hauptverfasser:	Slamon, Dennis J., Boone, Thomas C., Seeger, Robert C., Keith, Duane E., Chazin, Vicki, Lee, Hyun C., Souza, Lawrence M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Animals Base Sequence Biological and medical sciences Cancer Cancer research Carcinoma, Small Cell - metabolism Cell lines Cell nucleus Cell physiology Cell transformation and carcinogenesis. Action of oncogenes and antioncogenes Cellular immunity Chromosome mapping Fundamental and applied biological sciences. Psychology Genetics HT29 cells Immune Sera - immunology Immunoenzyme Techniques Leukemia, Myeloid, Acute - metabolism Lung Neoplasms - metabolism Medical research Molecular and cellular biology myc genes Neoplasm Proteins - genetics Neoplasm Proteins - isolation & purification Neoplasm Proteins - physiology Nervous system diseases Neuroblastoma Neuroblastoma - metabolism Neurons Oncogenes Oncology, Experimental Proteins Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - isolation & purification Proto-Oncogene Proteins - physiology Proto-Oncogene Proteins c-myc Proto-Oncogenes Rabbits - immunology Tumors
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