Synergistic effects of angiotensin-converting enzyme and angiotensin-II type 1 receptor gene polymorphisms on risk of myocardial infarction

Summary We reported from our previous multicentre case-control study that the deletion (D) polymorphism of the gene encoding angiotensin-converting enzyme (ACE) was associated with increased risk of myocardial infarction. The main function of ACE is to convert angiotensin I into angiotensin II, whic...

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Veröffentlicht in:	The Lancet (British edition) 1994-10, Vol.344 (8927), p.910-913
Hauptverfasser:	Tiret, L, Ducimetière, P, Bonnardeaux, A, Soubrier, F, Poirier, O, Ricard, S, Cambien, F, Marques-Vidal, P, Evans, A, Kee, F, Arveiler, D, Luc, G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Angiotensin AT1 receptors Angiotensin I Angiotensin II Apolipoprotein B Base Sequence Biological and medical sciences Cardiology. Vascular system Cardiovascular disease Cardiovascular diseases Case-Control Studies Clonal deletion Conversion Coronary artery disease Coronary heart disease Deoxyribonucleic acid DNA Enzymes Gene deletion Gene polymorphism Genes Genotype Health risk assessment Heart Heart attacks Heart diseases Heterozygotes Homozygotes Humans Male Medical research Medical sciences Middle Aged Molecular Sequence Data Myocardial infarction Myocardial Infarction - genetics Patients Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - genetics Polymorphism Polymorphism, Genetic Prevention Receptors, Angiotensin - genetics Risk analysis Risk Factors Synergistic effect Transversion
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