The effect of electroconvulsive shock on brain tubulin during development and aging
Effect of electroconvulsive shock on rat brain tubulin content was studied during maturation and aging. The results show that electroconvulsive shock had no effect on soluble tubulin in different brain structures of young animals (22 days) while the same treatment produced a marked decline in adult...
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| Veröffentlicht in: | Life sciences (1973) 1986-03, Vol.38 (13), p.1171-1178 |
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| container_title | Life sciences (1973) |
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| creator | Mileusnić, R. Veskov, R. Rakić, Lj |
| description | Effect of electroconvulsive shock on rat brain tubulin content was studied during maturation and aging. The results show that electroconvulsive shock had no effect on soluble tubulin in different brain structures of young animals (22 days) while the same treatment produced a marked decline in adult (95 days) and aged (490–511 days) animals. The same treatment produced inhibition of
3H-leucine incorporation into tubulin and decrease of
3H-colchicine binding in the proteins of synaptosomes isolated from the centricephalic structures of all the ages examined. Tubulin biosynthesis by free polysomes was not diminished to the extent which could explain the decrease of tubulin level found in the soluble or synaptosomal fraction. Thus, our results suggest that changes in soluble tubulin content in response to electroconvulsive shock could be a reflection of changes in equilibrium: tubulin dimers - microtubules - membrane-bound tubulin. |
| doi_str_mv | 10.1016/0024-3205(86)90171-2 |
| format | Article |
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3H-leucine incorporation into tubulin and decrease of
3H-colchicine binding in the proteins of synaptosomes isolated from the centricephalic structures of all the ages examined. Tubulin biosynthesis by free polysomes was not diminished to the extent which could explain the decrease of tubulin level found in the soluble or synaptosomal fraction. Thus, our results suggest that changes in soluble tubulin content in response to electroconvulsive shock could be a reflection of changes in equilibrium: tubulin dimers - microtubules - membrane-bound tubulin.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(86)90171-2</identifier><identifier>PMID: 3485754</identifier><identifier>CODEN: LIFSAK</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Aging ; Animals ; Applied sciences ; Biochemistry and metabolism ; Biological and medical sciences ; Brain - growth & development ; Brain - metabolism ; Central nervous system ; Colchicine - metabolism ; Electroshock ; Exact sciences and technology ; Fundamental and applied biological sciences. Psychology ; Leucine - metabolism ; Male ; Microtubules - metabolism ; Other techniques and industries ; Polyribosomes - metabolism ; Rats ; Rats, Inbred Lew ; Synaptosomes - metabolism ; Tubulin - metabolism ; Vertebrates: nervous system and sense organs</subject><ispartof>Life sciences (1973), 1986-03, Vol.38 (13), p.1171-1178</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c364t-794e88517aaa468a726416e13bc8558c7cc14ec5a79796e9394908b4bfd1d70b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0024-3205(86)90171-2$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8107648$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8118617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3485754$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mileusnić, R.</creatorcontrib><creatorcontrib>Veskov, R.</creatorcontrib><creatorcontrib>Rakić, Lj</creatorcontrib><title>The effect of electroconvulsive shock on brain tubulin during development and aging</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Effect of electroconvulsive shock on rat brain tubulin content was studied during maturation and aging. The results show that electroconvulsive shock had no effect on soluble tubulin in different brain structures of young animals (22 days) while the same treatment produced a marked decline in adult (95 days) and aged (490–511 days) animals. The same treatment produced inhibition of
3H-leucine incorporation into tubulin and decrease of
3H-colchicine binding in the proteins of synaptosomes isolated from the centricephalic structures of all the ages examined. Tubulin biosynthesis by free polysomes was not diminished to the extent which could explain the decrease of tubulin level found in the soluble or synaptosomal fraction. Thus, our results suggest that changes in soluble tubulin content in response to electroconvulsive shock could be a reflection of changes in equilibrium: tubulin dimers - microtubules - membrane-bound tubulin.</description><subject>Aging</subject><subject>Animals</subject><subject>Applied sciences</subject><subject>Biochemistry and metabolism</subject><subject>Biological and medical sciences</subject><subject>Brain - growth & development</subject><subject>Brain - metabolism</subject><subject>Central nervous system</subject><subject>Colchicine - metabolism</subject><subject>Electroshock</subject><subject>Exact sciences and technology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Leucine - metabolism</subject><subject>Male</subject><subject>Microtubules - metabolism</subject><subject>Other techniques and industries</subject><subject>Polyribosomes - metabolism</subject><subject>Rats</subject><subject>Rats, Inbred Lew</subject><subject>Synaptosomes - metabolism</subject><subject>Tubulin - metabolism</subject><subject>Vertebrates: nervous system and sense organs</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtLxDAQgIMouj7-gUIOInqoJm1evQiy-IIFD-o5pOlUo91kTdqC_96uu-xRTzPMfDMM3yB0TMklJVRcEZKzrMgJP1fioiRU0izfQhOqZJkRUdBtNNkge2g_pQ9CCOey2EW7BVNccjZBzy_vgKFpwHY4NBjaMYnBBj_0bXID4PQe7CcOHlfROI-7vurbMdZ9dP4N1zBAGxZz8B02vsbmbaweop3GtAmO1vEAvd7dvkwfstnT_eP0ZpbZQrAukyUDpTiVxhgmlJG5YFQALSqrOFdWWksZWG5kKUsBZVGykqiKVU1Na0mq4gCdrfYuYvjqIXV67pKFtjUeQp-0FFIIItQIshVoY0gpQqMX0c1N_NaU6KVLvRSll6K0EvrXpc7HsZP1_r6aQ70ZWssb-6frvknWtE003rq0wRSlSlD5P0akYMsjr1cYjMoGB1En68BbqF0cn6Lr4P4-9wfoVJv-</recordid><startdate>19860331</startdate><enddate>19860331</enddate><creator>Mileusnić, R.</creator><creator>Veskov, R.</creator><creator>Rakić, Lj</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860331</creationdate><title>The effect of electroconvulsive shock on brain tubulin during development and aging</title><author>Mileusnić, R. ; Veskov, R. ; Rakić, Lj</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c364t-794e88517aaa468a726416e13bc8558c7cc14ec5a79796e9394908b4bfd1d70b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Aging</topic><topic>Animals</topic><topic>Applied sciences</topic><topic>Biochemistry and metabolism</topic><topic>Biological and medical sciences</topic><topic>Brain - growth & development</topic><topic>Brain - metabolism</topic><topic>Central nervous system</topic><topic>Colchicine - metabolism</topic><topic>Electroshock</topic><topic>Exact sciences and technology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Leucine - metabolism</topic><topic>Male</topic><topic>Microtubules - metabolism</topic><topic>Other techniques and industries</topic><topic>Polyribosomes - metabolism</topic><topic>Rats</topic><topic>Rats, Inbred Lew</topic><topic>Synaptosomes - metabolism</topic><topic>Tubulin - metabolism</topic><topic>Vertebrates: nervous system and sense organs</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mileusnić, R.</creatorcontrib><creatorcontrib>Veskov, R.</creatorcontrib><creatorcontrib>Rakić, Lj</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mileusnić, R.</au><au>Veskov, R.</au><au>Rakić, Lj</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of electroconvulsive shock on brain tubulin during development and aging</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1986-03-31</date><risdate>1986</risdate><volume>38</volume><issue>13</issue><spage>1171</spage><epage>1178</epage><pages>1171-1178</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><coden>LIFSAK</coden><abstract>Effect of electroconvulsive shock on rat brain tubulin content was studied during maturation and aging. The results show that electroconvulsive shock had no effect on soluble tubulin in different brain structures of young animals (22 days) while the same treatment produced a marked decline in adult (95 days) and aged (490–511 days) animals. The same treatment produced inhibition of
3H-leucine incorporation into tubulin and decrease of
3H-colchicine binding in the proteins of synaptosomes isolated from the centricephalic structures of all the ages examined. Tubulin biosynthesis by free polysomes was not diminished to the extent which could explain the decrease of tubulin level found in the soluble or synaptosomal fraction. Thus, our results suggest that changes in soluble tubulin content in response to electroconvulsive shock could be a reflection of changes in equilibrium: tubulin dimers - microtubules - membrane-bound tubulin.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>3485754</pmid><doi>10.1016/0024-3205(86)90171-2</doi><tpages>8</tpages></addata></record> |
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| ispartof | Life sciences (1973), 1986-03, Vol.38 (13), p.1171-1178 |
| issn | 0024-3205 1879-0631 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Aging Animals Applied sciences Biochemistry and metabolism Biological and medical sciences Brain - growth & development Brain - metabolism Central nervous system Colchicine - metabolism Electroshock Exact sciences and technology Fundamental and applied biological sciences. Psychology Leucine - metabolism Male Microtubules - metabolism Other techniques and industries Polyribosomes - metabolism Rats Rats, Inbred Lew Synaptosomes - metabolism Tubulin - metabolism Vertebrates: nervous system and sense organs |
| title | The effect of electroconvulsive shock on brain tubulin during development and aging |
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