Treatment of NZB/NZW mice with total lymphoid irradiation: long-lasting suppression of disease without generalized immune suppression

We used total lymphoid irradiation (TLI; total dose = 3400 rad) to treat the lupus-like renal disease of 6-mo-old female NZB/NZW mice. Similar to our past studies, this treatment resulted in a marked prolongation of survival, decrease in proteinuria, and decrease in serum anti-DNA antibodies compare...

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Veröffentlicht in:	The Journal of immunology (1950) 1986-05, Vol.136 (9), p.3259-3265
Hauptverfasser:	Kotzin, BL, Arndt, R, Okada, S, Ward, R, Thach, AB, Strober, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibody-Producing Cells - metabolism Autoimmune Diseases - immunology Autoimmune Diseases - physiopathology B-Lymphocytes Biological and medical sciences Experimental and animal immunopathology. Animal models Female Immunoglobulin Allotypes - biosynthesis Immunopathology Immunosuppression - methods Leukocyte Count - radiation effects Lipopolysaccharides - pharmacology Lymphocyte Activation Lymphocyte Culture Test, Mixed Medical sciences Mice Mice, Inbred BALB C Mice, Inbred NZB Phytohemagglutinins - pharmacology Spleen T-Lymphocytes Time Factors Whole-Body Irradiation
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