Do antipsychotic drugs and serotonin down regulate [ 3H]-spiroperidol binding sites in human cortex?

[ 3H]-Spiroperidol binds at several specific sites in postmortem human prefrontal cortex at 21°C (1). The overall selectivity of these sites is serotonergic (1). At 37°C, there is a marked loss of specific [ 3H]-spiroperidol binding that occurs between 10 and 60 min (1). This loss of binding is not...

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