Role of factor XII in thrombin generation and fibrinolysis during cardiopulmonary bypass

During cardiopulmonary bypass, thrombin is generated, which is thought to be initiated by activation of factor XII on the surface of the bypass equipment. We present a patient with severe factor XII deficiency who underwent cardiac surgery. As much thrombin was formed during cardiopulmonary bypass (...

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Veröffentlicht in:	The Lancet (British edition) 1994-10, Vol.344 (8931), p.1192-1193
Hauptverfasser:	Burman, J.F., Chung, H.I., Lincoln, J.C.R., Lane, D.A., Philippou, H., Adami, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antithrombin III - analysis Biological and medical sciences Blood Cardiopulmonary Bypass Child Ductus Arteriosus, Patent - surgery Enzymes Factor XII - physiology Factor XII Deficiency - blood Factor XII Deficiency - complications Female Fibrinolysis Heart Heart Septal Defects - surgery Hematologic and hematopoietic diseases Humans Medical research Medical sciences Peptide Fragments - analysis Peptide Hydrolases - analysis Peptides Platelet diseases and coagulopathies Prothrombin - analysis Surgery Thrombin - metabolism
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