Effect of lithium therapy on inflammatory response
Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68 +/- 3.1 vs. 93 +/- 3.4 mV/5 X 10(5) cells). Preincubation of normal cells with serum from pat...
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| Veröffentlicht in: | Inflammation 1986-03, Vol.10 (1), p.49-57 |
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| creator | O'RIORDAN, J. W KELLEHER, D WILLIAMS, Y BLOOMFIELD, F. J |
| description | Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68 +/- 3.1 vs. 93 +/- 3.4 mV/5 X 10(5) cells). Preincubation of normal cells with serum from patients also resulted in reduced chemiluminescence activity when the cells were stimulated with autologous serum-coated zymosan (47 +/- 4.5 vs. 64 +/- 6.3 mV/5 X 10(5) cells). Spontaneous complement conversion was increased in the serum of patients on lithium therapy (46.3 +/- 3.8 vs. 25.3 +/- 2.5% conversion). These studies demonstrated that lithium, at safe therapeutic levels (0.4-0.9 mmol/liter), significantly altered complement conversion and had a marked affect on chemiluminescence activity by normal cells. |
| doi_str_mv | 10.1007/BF00916040 |
| format | Article |
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W ; KELLEHER, D ; WILLIAMS, Y ; BLOOMFIELD, F. J</creator><creatorcontrib>O'RIORDAN, J. W ; KELLEHER, D ; WILLIAMS, Y ; BLOOMFIELD, F. J</creatorcontrib><description>Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68 +/- 3.1 vs. 93 +/- 3.4 mV/5 X 10(5) cells). Preincubation of normal cells with serum from patients also resulted in reduced chemiluminescence activity when the cells were stimulated with autologous serum-coated zymosan (47 +/- 4.5 vs. 64 +/- 6.3 mV/5 X 10(5) cells). Spontaneous complement conversion was increased in the serum of patients on lithium therapy (46.3 +/- 3.8 vs. 25.3 +/- 2.5% conversion). These studies demonstrated that lithium, at safe therapeutic levels (0.4-0.9 mmol/liter), significantly altered complement conversion and had a marked affect on chemiluminescence activity by normal cells.</description><identifier>ISSN: 0360-3997</identifier><identifier>EISSN: 1573-2576</identifier><identifier>DOI: 10.1007/BF00916040</identifier><identifier>PMID: 3957422</identifier><identifier>CODEN: INFLD4</identifier><language>eng</language><publisher>New York, NY: Springer</publisher><subject>Adult ; Biological and medical sciences ; Complement C3 - analysis ; Complement C3c ; Complement Fixation Tests ; Complement System Proteins - immunology ; Female ; General aspects ; Humans ; Inflammation - immunology ; Lithium - blood ; Lithium - therapeutic use ; Luminescent Measurements ; Male ; Medical sciences ; Middle Aged ; Neuropharmacology ; Neutrophils - immunology ; Opsonin Proteins ; Pharmacology. 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W</creatorcontrib><creatorcontrib>KELLEHER, D</creatorcontrib><creatorcontrib>WILLIAMS, Y</creatorcontrib><creatorcontrib>BLOOMFIELD, F. J</creatorcontrib><title>Effect of lithium therapy on inflammatory response</title><title>Inflammation</title><addtitle>Inflammation</addtitle><description>Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68 +/- 3.1 vs. 93 +/- 3.4 mV/5 X 10(5) cells). Preincubation of normal cells with serum from patients also resulted in reduced chemiluminescence activity when the cells were stimulated with autologous serum-coated zymosan (47 +/- 4.5 vs. 64 +/- 6.3 mV/5 X 10(5) cells). Spontaneous complement conversion was increased in the serum of patients on lithium therapy (46.3 +/- 3.8 vs. 25.3 +/- 2.5% conversion). These studies demonstrated that lithium, at safe therapeutic levels (0.4-0.9 mmol/liter), significantly altered complement conversion and had a marked affect on chemiluminescence activity by normal cells.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Complement C3 - analysis</subject><subject>Complement C3c</subject><subject>Complement Fixation Tests</subject><subject>Complement System Proteins - immunology</subject><subject>Female</subject><subject>General aspects</subject><subject>Humans</subject><subject>Inflammation - immunology</subject><subject>Lithium - blood</subject><subject>Lithium - therapeutic use</subject><subject>Luminescent Measurements</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neuropharmacology</subject><subject>Neutrophils - immunology</subject><subject>Opsonin Proteins</subject><subject>Pharmacology. Drug treatments</subject><subject>Zymosan - immunology</subject><issn>0360-3997</issn><issn>1573-2576</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLAzEUhYMotVY37oVZiAth9OadLG1pVSi40fWQpAkdmZfJzKL_3pEOdXXhnI_D5UPoFsMTBpDPyw2AxgIYnKE55pLmhEtxjuZABeRUa3mJrlL6BgClFZ2hGdVcMkLmiKxD8K7P2pBVZb8vhzrr9z6a7pC1TVY2oTJ1bfo2HrLoU9c2yV-ji2Cq5G-mu0Bfm_Xn6i3ffry-r162uaMY97lmyksuKJMkYBWsU45Jp4AQy8bE7qgnnAnhOaPAnSfCUkZ3SlqurAFFF-jhuNvF9mfwqS_qMjlfVabx7ZAKKaTAUogRfDyCLrYpRR-KLpa1iYcCQ_EnqPgXNMJ30-pga787oZORsb-fepOcqUI0jSvTCZNajO9K-gu4JmrW</recordid><startdate>19860301</startdate><enddate>19860301</enddate><creator>O'RIORDAN, J. W</creator><creator>KELLEHER, D</creator><creator>WILLIAMS, Y</creator><creator>BLOOMFIELD, F. J</creator><general>Springer</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19860301</creationdate><title>Effect of lithium therapy on inflammatory response</title><author>O'RIORDAN, J. W ; KELLEHER, D ; WILLIAMS, Y ; BLOOMFIELD, F. J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-948e7563472f18fbc8c47c8022b42f1bd3e25466e54305ce26b343d87b58ba083</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Complement C3 - analysis</topic><topic>Complement C3c</topic><topic>Complement Fixation Tests</topic><topic>Complement System Proteins - immunology</topic><topic>Female</topic><topic>General aspects</topic><topic>Humans</topic><topic>Inflammation - immunology</topic><topic>Lithium - blood</topic><topic>Lithium - therapeutic use</topic><topic>Luminescent Measurements</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Neuropharmacology</topic><topic>Neutrophils - immunology</topic><topic>Opsonin Proteins</topic><topic>Pharmacology. Drug treatments</topic><topic>Zymosan - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>O'RIORDAN, J. W</creatorcontrib><creatorcontrib>KELLEHER, D</creatorcontrib><creatorcontrib>WILLIAMS, Y</creatorcontrib><creatorcontrib>BLOOMFIELD, F. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Inflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>O'RIORDAN, J. W</au><au>KELLEHER, D</au><au>WILLIAMS, Y</au><au>BLOOMFIELD, F. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of lithium therapy on inflammatory response</atitle><jtitle>Inflammation</jtitle><addtitle>Inflammation</addtitle><date>1986-03-01</date><risdate>1986</risdate><volume>10</volume><issue>1</issue><spage>49</spage><epage>57</epage><pages>49-57</pages><issn>0360-3997</issn><eissn>1573-2576</eissn><coden>INFLD4</coden><abstract>Chemiluminescence produced by normal cells was reduced in response to zymosan which was opsonized with serum from patients on prophylactic lithium therapy, compared to control serum from normal subjects (68 +/- 3.1 vs. 93 +/- 3.4 mV/5 X 10(5) cells). Preincubation of normal cells with serum from patients also resulted in reduced chemiluminescence activity when the cells were stimulated with autologous serum-coated zymosan (47 +/- 4.5 vs. 64 +/- 6.3 mV/5 X 10(5) cells). Spontaneous complement conversion was increased in the serum of patients on lithium therapy (46.3 +/- 3.8 vs. 25.3 +/- 2.5% conversion). These studies demonstrated that lithium, at safe therapeutic levels (0.4-0.9 mmol/liter), significantly altered complement conversion and had a marked affect on chemiluminescence activity by normal cells.</abstract><cop>New York, NY</cop><pub>Springer</pub><pmid>3957422</pmid><doi>10.1007/BF00916040</doi><tpages>9</tpages></addata></record> |
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| ispartof | Inflammation, 1986-03, Vol.10 (1), p.49-57 |
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| language | eng |
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| source | MEDLINE; SpringerLink Journals |
| subjects | Adult Biological and medical sciences Complement C3 - analysis Complement C3c Complement Fixation Tests Complement System Proteins - immunology Female General aspects Humans Inflammation - immunology Lithium - blood Lithium - therapeutic use Luminescent Measurements Male Medical sciences Middle Aged Neuropharmacology Neutrophils - immunology Opsonin Proteins Pharmacology. Drug treatments Zymosan - immunology |
| title | Effect of lithium therapy on inflammatory response |
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