A novel hypothesis: Specific oncogenes and tumor suppression genes are involved in the expression of the proopiomelanocortin gene by small cell lung cancer
The endogenous opioid β-endorphin, a derivative of proopiomelanocortin, stimulates the growth of cloned human small cell lung carcinoma. The present hypothesis states that mutations of the retinoblastoma gene (a tumor suppressor gene) associated to the malignant transformation of bronchial cells wou...
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| Veröffentlicht in: | Medical hypotheses 1994-06, Vol.42 (6), p.397-399 |
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| container_title | Medical hypotheses |
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| creator | Amsler, U.J. Pasi, A. Qu, B.X. |
| description | The endogenous opioid β-endorphin, a derivative of proopiomelanocortin, stimulates the growth of cloned human small cell lung carcinoma. The present hypothesis states that mutations of the retinoblastoma gene (a tumor suppressor gene) associated to the malignant transformation of bronchial cells would trigger a cascade of biomolecular events leading to ‘de novo’ proopiomelanocortin expression in small cell lung carcinoma. |
| doi_str_mv | 10.1016/0306-9877(94)90162-7 |
| format | Article |
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The present hypothesis states that mutations of the retinoblastoma gene (a tumor suppressor gene) associated to the malignant transformation of bronchial cells would trigger a cascade of biomolecular events leading to ‘de novo’ proopiomelanocortin expression in small cell lung carcinoma.</description><subject>ACTH Syndrome, Ectopic - etiology</subject><subject>beta-Endorphin - metabolism</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Small Cell - genetics</subject><subject>Carcinoma, Small Cell - metabolism</subject><subject>Cushing Syndrome - etiology</subject><subject>Cushing Syndrome - genetics</subject><subject>Female</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>Genes, fos</subject><subject>Genes, Retinoblastoma</subject><subject>Hormones, Ectopic - biosynthesis</subject><subject>Hormones, Ectopic - genetics</subject><subject>Humans</subject><subject>Lung Neoplasms - genetics</subject><subject>Lung Neoplasms - metabolism</subject><subject>Medical sciences</subject><subject>Models, Biological</subject><subject>Neoplasm Proteins - biosynthesis</subject><subject>Neoplasm Proteins - genetics</subject><subject>Pneumology</subject><subject>Pro-Opiomelanocortin - biosynthesis</subject><subject>Pro-Opiomelanocortin - genetics</subject><subject>Protein Processing, Post-Translational</subject><subject>Proto-Oncogene Proteins c-fos - physiology</subject><subject>Retinoblastoma Protein - deficiency</subject><subject>Retinoblastoma Protein - physiology</subject><subject>Tumors of the respiratory system and mediastinum</subject><issn>0306-9877</issn><issn>1532-2777</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1994</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc-OFCEQxonRrOPqG2jCwRg9tEJDd4EHk83Gf8kmHtQzYehiF9MNLXRPnGfxZWV2JnP0AqTqV1-K7yPkOWdvOeP9OyZY32gF8FrLN7pW2gYekA3vRNu0APCQbM7IY_KklF-MMS2FuiAXoEXHlNqQv1c0ph2O9G4_p-UOSyjv6fcZXfDB0RRdusWIhdo40GWdUqZlneeMpYQU6amXkYa4S-MOh_qgVYbinzOU_H1lzinNIU042phcyks4ztPtnpbJjiN1WI9xjbfU2egwPyWPvB0LPjvdl-Tnp48_rr80N98-f72-ummcUP3SdICogQ89eoFMQNf1mm9b23ZukL5vlZYDY5w7D2orhfQa0HpllfIeYPDikrw66tYVf69YFjOFcljGRkxrMdBDz4F1FZRH0OVUSkZv5hwmm_eGM3PIxBwMNwfDjZbmPhMDdezFSX_dTjich04h1P7LU98WZ0ef6-9DOWOy7aSAvmIfjhhWL3YBsykuYDVqCBndYoYU_r_HP4x-q8I</recordid><startdate>19940601</startdate><enddate>19940601</enddate><creator>Amsler, U.J.</creator><creator>Pasi, A.</creator><creator>Qu, B.X.</creator><general>Elsevier Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19940601</creationdate><title>A novel hypothesis: Specific oncogenes and tumor suppression genes are involved in the expression of the proopiomelanocortin gene by small cell lung cancer</title><author>Amsler, U.J. ; Pasi, A. ; Qu, B.X.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c386t-57ee971d6ef3e03755691b2a25cd4f62894d0011cf78b434f97eaf8a88ff77df3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>ACTH Syndrome, Ectopic - etiology</topic><topic>beta-Endorphin - metabolism</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Small Cell - genetics</topic><topic>Carcinoma, Small Cell - metabolism</topic><topic>Cushing Syndrome - etiology</topic><topic>Cushing Syndrome - genetics</topic><topic>Female</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>Genes, fos</topic><topic>Genes, Retinoblastoma</topic><topic>Hormones, Ectopic - biosynthesis</topic><topic>Hormones, Ectopic - genetics</topic><topic>Humans</topic><topic>Lung Neoplasms - genetics</topic><topic>Lung Neoplasms - metabolism</topic><topic>Medical sciences</topic><topic>Models, Biological</topic><topic>Neoplasm Proteins - biosynthesis</topic><topic>Neoplasm Proteins - genetics</topic><topic>Pneumology</topic><topic>Pro-Opiomelanocortin - biosynthesis</topic><topic>Pro-Opiomelanocortin - genetics</topic><topic>Protein Processing, Post-Translational</topic><topic>Proto-Oncogene Proteins c-fos - physiology</topic><topic>Retinoblastoma Protein - deficiency</topic><topic>Retinoblastoma Protein - physiology</topic><topic>Tumors of the respiratory system and mediastinum</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Amsler, U.J.</creatorcontrib><creatorcontrib>Pasi, A.</creatorcontrib><creatorcontrib>Qu, B.X.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical hypotheses</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Amsler, U.J.</au><au>Pasi, A.</au><au>Qu, B.X.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A novel hypothesis: Specific oncogenes and tumor suppression genes are involved in the expression of the proopiomelanocortin gene by small cell lung cancer</atitle><jtitle>Medical hypotheses</jtitle><addtitle>Med Hypotheses</addtitle><date>1994-06-01</date><risdate>1994</risdate><volume>42</volume><issue>6</issue><spage>397</spage><epage>399</epage><pages>397-399</pages><issn>0306-9877</issn><eissn>1532-2777</eissn><abstract>The endogenous opioid β-endorphin, a derivative of proopiomelanocortin, stimulates the growth of cloned human small cell lung carcinoma. The present hypothesis states that mutations of the retinoblastoma gene (a tumor suppressor gene) associated to the malignant transformation of bronchial cells would trigger a cascade of biomolecular events leading to ‘de novo’ proopiomelanocortin expression in small cell lung carcinoma.</abstract><cop>Kidlington</cop><pub>Elsevier Ltd</pub><pmid>7935088</pmid><doi>10.1016/0306-9877(94)90162-7</doi><tpages>3</tpages></addata></record> |
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| ispartof | Medical hypotheses, 1994-06, Vol.42 (6), p.397-399 |
| issn | 0306-9877 1532-2777 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | ACTH Syndrome, Ectopic - etiology beta-Endorphin - metabolism Biological and medical sciences Carcinoma, Small Cell - genetics Carcinoma, Small Cell - metabolism Cushing Syndrome - etiology Cushing Syndrome - genetics Female Gene Expression Regulation, Neoplastic Genes, fos Genes, Retinoblastoma Hormones, Ectopic - biosynthesis Hormones, Ectopic - genetics Humans Lung Neoplasms - genetics Lung Neoplasms - metabolism Medical sciences Models, Biological Neoplasm Proteins - biosynthesis Neoplasm Proteins - genetics Pneumology Pro-Opiomelanocortin - biosynthesis Pro-Opiomelanocortin - genetics Protein Processing, Post-Translational Proto-Oncogene Proteins c-fos - physiology Retinoblastoma Protein - deficiency Retinoblastoma Protein - physiology Tumors of the respiratory system and mediastinum |
| title | A novel hypothesis: Specific oncogenes and tumor suppression genes are involved in the expression of the proopiomelanocortin gene by small cell lung cancer |
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